Adderall is a controlled substance prescription medication that’s used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy in adults and some pediatric patients.
In general, healthcare providers prescribe a lower starting dosage of Adderall. Then they increase the dosage slowly over time until your symptoms are well managed.
Adderall is typically taken one to three times per day, depending upon condition and if using Adderall IR (immediate-release formulation) or Adderall XR (extended-release formulation). If you’re taking multiple doses per day, the doses should be separated by four to six hours to achieve the desired effect.
Stopping Adderall abruptly can cause serious withdrawal symptoms. Due to this risk, you should not stop taking Adderall before talking to a healthcare provider.
Adderall is a prescription CNS stimulant medication that combines amphetamine and dextroamphetamine to enhance focus, attention, and impulse control in patients with ADHD. It should only be taken according to a doctor’s instructions. It is also prescribed for narcolepsy to reduce severe tiredness during the day. Adderall is available in two forms:
Immediate-release (IR): Taken 1–3 times daily.
Extended-release (XR): Taken once daily.
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Adderall tablets come in seven different dose strengths.
5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg, 20 mg, 30 mg
5 mg, 10 mg, 15 mg, 20 mg, 25 mg, 30 mg
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Adderall dosage chart |
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|---|---|---|---|---|
| Indication | Age | Starting dosage | Standard dosage | Maximum dosage |
| ADHD | Adults and children 6 years and older | 5 mg by mouth once or twice daily | 5–40 mg by mouth once per day or divided into 2-3 daily doses every 4–6 hours | Not specified |
| Children 3–5 years | 2.5 mg by mouth once daily | 2.5–40 mg by mouth once per day or divided into 2–3 daily doses every 4–6 hours | Not specified | |
| Narcolepsy | Adults and children 12 years and older | 10 mg by mouth once daily | 20–60 mg by mouth once per day or divided into 2–3 daily doses every 4–6 hours | Not specified |
| Children 6–11 years | 5 mg by mouth once daily | 5–60 mg by mouth once per day or divided into 2–3 daily doses every 4–6 hours | Not specified |
Each tablet contains amphetamine salts dextroamphetamine sulfate, amphetamine sulfate, dextroamphetamine saccharate, and d,1-amphetamine aspartate. Tablets are scored to allow them to be halved into two smaller doses.
The pediatric use of Adderall is approved for children as young as 3 years of age for ADHD and in children as young as 6 diagnosed with narcolepsy.
Adderall dosage by age |
||
|---|---|---|
| Age | Standard dosage | Maximum dosage |
| 3-5 years old | 2.5–40 mg (ADHD) divided into 1-3 daily doses taken by mouth every 4-6 hours | Not specified |
| 6 and older | ADHD: 5–40 mg (ADHD) or 5–60 mg (narcolepsy) divided into 1-3 daily doses taken by mouth every 4-6 hours | Not specified |
How long does it take Adderall to work?
Immediate-release (IR): Effects begin within 30–45 minutes, peaking in 1–3 hours.
Extended-release (XR): Effects begin within 1–2 hours, lasting up to 12 hours.
Food does not significantly impact Adderall absorption, but taking it with a high-fat meal may slightly delay onset. In addition, amphetamine blood levels may be reduced if consumed with acidic foods, juices, or Vitamin C.
Detection times vary by test type:
Urine: 72–96 hours
Blood: Up to 46 hours
Saliva: 20–50 hours
Hair: Up to 3 months
A missed dose can be taken when remembered, but avoid taking a dose late in the day due to the potential for adverse effects. Remember that doses should be taken every four to six hours, so taking a missed dose will reset the clock. Never take additional doses of Adderall to make up for a missed dose due to the risk of potential side effects.
Adderall can cause physical dependence when taken for a prolonged period of time. Because of its potential risks for substance abuse and addiction, the Drug Enforcement Agency (DEA) labels Adderall as a Schedule II controlled substance. Suddenly stopping Adderall can significantly impact quality of life by causing severe tiredness, depression, mood changes, and sleep problems. Before stopping Adderall, talk to a healthcare provider, like a doctor or pharmacist. In most cases, they will come up with treatment options for you to lower your dose gradually over a long time until it’s safe for you to stop the drug completely. If you’re experiencing serious side effects like an allergic reaction, or other side effects that won’t go away, talk to medical professionals right away. There may be some situations where you may need to stop Adderall abruptly.
40-60mg/day in 2-3 divided doses
40-60mg/day in 1 daily dose (taken in the morning)
In general, the starting dose is low and the lowest effective dose is continued under close medical supervision. While the drugmaker hasn’t specified a maximum dosage, the Prescriber’s Digital Reference (formerly the Physician’s Desk Reference) recommends a maximum dose of 60 mg per day for ADHD in adults and children 6 years and older, although higher doses above 40 mg per day are rarely necessary. The maximum dosage for children ages 3 to 5 years with ADHD is 40 mg per day. For adults and children with narcolepsy, the maximum dosage is 60 mg per day.
Drugs like Adderall that affect the brain can have a number of drug interactions. Examples of drugs that may interact with Adderall include:
Certain antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) Other stimulants
Antihypertensives
Beta blockers
Certain mental health disorder drugs, such as monoamine oxidase inibitors (MAOIs)
Certain seizure medications
To lower the risk of interactions, discuss all current prescription and over-the-counter medications and medical conditions with a healthcare professional before you start Adderall treatment.
Adderall (dextroamphetamine saccharate, amphetamine aspartate, dextroamphetamine sulfate, and amphetamine sulfate tablet) [prescribing information]. Parsippany, NJ: Teva Pharmaceuticals (2024)
Amphetamine aspartate monohydrate/amphetamine sulfate/dextroamphetamine saccharate/dextroamphetamine sulfate—drug summary, Prescriber’s Digital Reference (2024)
Amphetamine compound summary, U.S. National Library of Medicine (2025)
Amphetamine, past, and present—a pharmacological and clinical perspective, Journal of Psychopharmacology (2013)
Dextroamphetamine-Amphetamine, StatPearls (2023)
How long does Adderall stay in your system? American Addiction Centers (2024)
New formulations of stimulants: An update for clinicians, Journal of Child and Adolescent Psychopharmacology (2019)
The treatment of narcolepsy with amphetamine-based stimulant medications: A call for better understanding, Journal of Clinical Sleep Medicine (2019)
Marissa Walsh, Pharm.D., BCPS-AQ ID, graduated with her Doctor of Pharmacy degree from the University of Rhode Island in 2009, then went on to complete a PGY1 Pharmacy Practice Residency at Charleston Area Medical Center in Charleston, West Virginia, and a PGY2 Infectious Diseases Pharmacy Residency at Maine Medical Center in Portland, Maine. Dr. Walsh has worked as a clinical pharmacy specialist in Infectious Diseases in Portland, Maine, and Miami, Florida, prior to setting into her current role in Buffalo, New York, where she continues to work as an Infectious Diseases Pharmacist in a hematology/oncology population.
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