What is Dutoprol? Uses, warnings & side effects

Updated May 14, 2025  •  Published May 27, 2022

Dutoprol overview

BRAND NAMES:

  • Dutoprol, Lopressor HCT

Generic Names:

  • Dutoprol

Uses:

  • Treats high blood pressure. This medicine is a combination of a beta-blocker and a diuretic (water pill).

Therapeutic Classes:

  • Beta-Adrenergic Blocker, Cardioselective/Thiazide Combination, Beta-Adrenergic Blocker/Thiazide Combination

Forms:

  • Tablet, Long Acting Tablet

How it’s taken:

  • By mouth

What is Dutoprol used for?

What form(s) does Dutoprol come in?

  • Tablet

  • Long Acting Tablet

What are common Dutoprol dosages?

  • Tablet Extended Release 24 Hour 50-12.5MG

  • Tablet Extended Release 24 Hour 100-12.5MG

Dutoprol images - What does Dutoprol look like?

  • Dutoprol
    100-12.5mg tablet extended release 24 hour

  • Dutoprol
    25-12.5mg tablet extended release 24 hour

  • Dutoprol
    50-12.5mg tablet extended release 24 hour

How to take Dutoprol

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Tablet: Take it with a meal or just after a meal.

  • Extended-release tablet: Take it with or without food. Swallow the extended-release tablet whole. Do not crush, break, or chew it.

  • Missed dose: If you miss a dose or forget to use your medicine, skip the missed dose. Never take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

What to do if you miss a dose of Dutoprol

Dutoprol contraindications - Who shouldn't take Dutoprol?

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to metoprolol, hydrochlorothiazide, or sulfa drugs.

Dutoprol warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel disease, heart rhythm problems (such as bradycardia), glaucoma, gout, diabetes, lupus, an overactive thyroid, pheochromocytoma, trouble urinating, or a history of asthma or lung disease.

  • This medicine may cause new or worsening heart failure.

  • Do not stop using this medicine suddenly without asking your doctor, or you could develop life-threatening heart problems.

  • Tell any doctor or dentist who treats you that you are using this medicine, especially before you have any type of surgery.

  • This medicine may cause you to feel dizzy, drowsy, or lightheaded. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Stand or sit up slowly if you are dizzy or lightheaded.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Lightheadedness, dizziness, or fainting

  • Slow, fast, pounding, or uneven heartbeat

  • Sudden and severe stomach pain, nausea, or vomiting

  • Swelling in your hands, feet, ankles, or legs, tiredness

  • Trouble breathing or wheezing

Dutoprol interactions & what to avoid when taking Dutoprol

  • Some foods and medicines can affect how metoprolol/hydrochlorothiazide works. Tell your doctor if you use the following:Cholestyramine, cimetidine, clonidine, colestipol, digoxin, diphenhydramine, fluoxetine, hydroxychloroquine, lithium, methyldopa, paroxetine, propafenone, quinidine, reserpine, ritonavir, terbinafine, thioridazineInsulin or diabetes medicineMAO inhibitor (MAOI)NSAID pain or arthritis medicine (such as aspirin, diclofenac, indomethacin, naproxen)Steroid medicine (such as hydrocortisone, methylprednisolone, prednisolone, prednisone)

  • Ask your doctor before you use medicines, supplements, or salt substitutes that contain potassium.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Tell any doctor or dentist who treats you that you are using this medicine, especially before you have any type of surgery.

  • This medicine may cause you to feel dizzy, drowsy, or lightheaded. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Stand or sit up slowly if you are dizzy or lightheaded.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Dutoprol side effects - How does Dutoprol make you feel?

Serious Side Effects

  • Slow, fast, pounding, or uneven heartbeat

  • Trouble breathing or wheezing

  • Lightheadedness, dizziness, or fainting

  • Swelling in your hands, feet, ankles, or legs, tiredness

  • Confusion, weakness, and muscle twitching

  • Sudden and severe stomach pain, nausea, or vomiting

  • Chest pain that may spread, nausea, unusual sweating, fainting

  • Eye pain, vision changes, seeing halos around lights

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

  • Dry mouth, increased thirst, or muscle cramps

  • Change in how much or how often you urinate

Less Serious Side Effects

  • Diarrhea, constipation, loss of appetite, or stomach upset

  • Depression