Lisinopril-hydrochlorothiazide is a generic blood pressure medication that combines an ACE inhibitor with a diuretic. Both reduce blood pressure but do so in different ways. Lisinopril widens blood vessels, while hydrochlorothiazide increases the body’s elimination of water and salt and decreases blood volume. The two drugs are commonly prescribed together when one drug is not successful. Doses are taken as tablets once daily.
Check our best Lisinopril-HCTZ prices
Zestoretic
Lisinopril-hydrochlorothiazide
Treats high blood pressure
ACE Inhibitor/thiazide combination, antihypertensive, cardiovascular agent
Tablet
By mouth
Lisinopril-hydrochlorothiazide helps reduce blood pressure in people diagnosed with high blood pressure (hypertension) that is not being controlled by one drug.
Tablet
10 mg lisinopril/12.5 mg hydrochlorothiazide
20-12.5 mg
20-25 mg
For high blood pressure:
Starting dose: 10 mg/12.5 mg–20 mg/12.5 mg tablet taken once daily
Maximum dose: 4, 20 mg/12.5 mg tablets taken once daily
Lisinopril-hydroCHLOROthiazide
30 tablets bottle
Lisinopril-hydroCHLOROthiazide
10-12.5mg tablet
Lisinopril-hydroCHLOROthiazide
20-12.5mg tablet
Lisinopril-hydroCHLOROthiazide
20-25mg tablet
Take this drug as directed. The dose may need to be changed at the start and during the course of treatment.
Do not take more than prescribed. If the medicine is not working, consult with the prescriber.
Lisinopril-hydrochlorothiazide tablets can be taken with or without food.
Swallow the tablet whole with a drink of water.
Store the tablets at room temperature protected from excessive light or humidity.
Take a missed dose as soon as you remember.
If it is almost time for your next dose, wait until then and take a regular dose.
Take only one dose daily.
Do not take an extra dose to compensate for a missed dose.
This medicine is not right for everyone.
Do not use it if you:
Are pregnant
Cannot urinate
Have known allergies to lisinopril, hydrochlorothiazide, other ACE inhibitors, or sulfa drugs
A history of face, neck, or intestinal swelling (angioedema) caused by an ACE inhibitor
Regular office visits and blood tests are required to monitor therapy and prevent potentially serious problems. Keep all appointments.
Tell all other doctors or healthcare providers that you are taking lisinopril and hydrochlorothiazide.
Before taking lisinopril-hydrochlorothiazide, tell the doctor if you are pregnant or plan to become pregnant. This drug can harm an unborn baby. Immediately inform the prescriber if you become pregnant while taking this drug.
Make sure the prescriber is familiar with all your medical conditions, particularly:
Kidney problems
Liver problems
Heart problems
Diabetes
Trouble urinating
Uric acid problems or gout
Electrolyte problems
Lupus
A heart problem called left ventricular outflow obstruction
Tell the prescriber if you are breastfeeding or plan to breastfeed.
Lisinopril-hydrochlorothiazide can cause serious problems in some people, including:
Low blood pressure
Electrolyte imbalances (low potassium, low sodium, low magnesium, and high calcium)
Angioedema (severe swelling) of the head, neck, or intestines
Liver problems
Kidney problems
High uric acid or gout
High cholesterol or fats in the blood
High blood sugar
Weakened immune system
Sudden and severe glaucoma
Severe allergic or drug reactions
This medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Stand or sit up slowly if you feel lightheaded or dizzy. Tell the prescriber if you experience symptoms of low blood pressure.
Immediately inform the doctor if you notice signs of angioedema, such as swelling of the face or neck. Abdominal pain is the most common symptom of intestinal angioedema.
This drug can weaken the immune system and make people vulnerable to infections. Take precautions to prevent illness and injury. Immediately contact the prescriber if you notice symptoms of an infection.
Drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting while you are using this medicine.
Lisinopril and hydrochlorothiazide increase the risk of getting skin cancer. Wear sunscreen and do not use sunlamps or tanning beds.
Do not stop using the medicine without talking to the prescriber.
Do not take this medicine if you are taking the blood pressure medications:
Tekturna (aliskiren)
Entresto (sacubitril/valsartan)
Lisinopril-hydrochlorothiazide has a long list of potentially dangerous drug interactions. Carry a list of all the prescription drugs, over-the-counter medications, and supplements you take to share with the prescriber before you start taking this drug. Make sure the prescriber knows if you are taking:
Other blood pressure drugs
Drugs that make you pee (diuretics)
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin or ibuprofen
Diabetes medications, including insulin
Immune suppressants called mTor inhibitors, such as tacrolimus or everolimus
Narcotic medications (opioids)
Barbiturates
Muscle relaxants
Cholesterol drugs called bile acid sequestrants
Potassium supplements
Potassium-containing salt substitutes
Lithium
Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.
When taking hydrochlorothiazide, alcohol, narcotic pain relievers, or barbiturates may cause you to feel faint or fall down when you stand up.
Talk to a doctor if you notice any signs or symptoms of a serious side effect, including:
Dry mouth, increased thirst, weakness
Drowsiness, low energy, restlessness, confusion
Muscle pains, muscle cramps, muscle weakness, seizures
Infrequent urination, racing heartbeat, nausea, vomiting, numbness
Change in how much or how often you urinate
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Fever, chills, sore throat, body aches
Lightheadedness, dizziness, fainting
Eye pain, vision changes
Severe abdominal pain
Blistering, peeling, red skin rash
Angioedema: swelling of the face, tongue, or neck, throat tightness, trouble breathing, abdominal pain
Allergic reaction: Itching, rash, hives, trouble breathing, low blood pressure, dizziness, fainting, weak and rapid pulse
Dizziness
Headache
Dry cough
Lisinopril and hydrochlorothiazide tablet prescribing information, DailyMed (NIH National Library of Medicine)
Zestoretic drug summary, Prescriber’s Digital Reference (PDR)
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