Estradiol Coupons & Prices

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Estradiol works as a female hormone replacement therapy to increase estrogen levels and relieve symptoms of menopause. It can also be used for the prevention of osteoporosis and the palliative treatment of advanced-stage breast and prostate cancer. The average cost of oral Estradiol is $188.97 for 1, 42.5gm of 0.1mg/gm tube of cream. You may be able to purchase Estradiol at a price of $32.51 for 1, 42.5gm of 0.1mg/gm tube of cream with a SingleCare card.

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Estradiol coupon at Walmart Neighborhood Market Pharmacy
$35.51
$ 32.51
$3 off with signupwith signup

Show this free card to your pharmacist.

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Estradiol coupon at Walmart Pharmacy
$35.51
$ 32.51
$3 off with signupwith signup

Save an extra $3 on any eligible prescription! Sign up for free

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and it's free to join

Estradiol coupon at CVS Pharmacy
$39.44
$ 36.44
$3 off with signupwith signup
Estradiol coupon at Food Lion Pharmacy
$ 37.33
Estradiol coupon at Publix Pharmacy
$ 40.59
Estradiol coupon at Walgreens Pharmacy
$48.18
$ 45.18
$3 off with signupwith signup
$ 57.99
$84.55
$ 81.55
$3 off with signupwith signup
$84.55
$ 81.55
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

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About Estradiol

Estradiol works as a female hormone replacement therapy to increase estrogen levels and relieve symptoms of menopause. It can also be used for the prevention of osteoporosis and the palliative treatment of advanced-stage breast and prostate cancer. The average cost of oral Estradiol is $188.97 for 1, 42.5gm of 0.1mg/gm tube of cream. You may be able to purchase Estradiol at a price of $32.51 for 1, 42.5gm of 0.1mg/gm tube of cream with a SingleCare card.

Estradiol Price History & Information

Price History for Estradiol

1 count, tube, 42.5gm of 0.1mg/gm

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Estradiol

1 count, tube, 42.5gm of 0.1mg/gm
PharmacyEstradiol Retail PriceEstradiol SingleCare Price
CVS Pharmacy$112.20$67.90
Walmart$46.49$36.20
Walgreens$83.10$67.58
Kroger Pharmacy$306.82$84.99
Albertsons Pharmacy$122.83$42.92

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Estradiol

Estradiol works as a female hormone replacement therapy to increase estrogen levels and relieve symptoms of menopause. It can also be used for the prevention of osteoporosis and the palliative treatment of advanced-stage breast and prostate cancer. The average cost of oral Estradiol is $188.97 for 1, 42.5gm of 0.1mg/gm tube of cream. You may be able to purchase Estradiol at a price of $32.51 for 1, 42.5gm of 0.1mg/gm tube of cream with a SingleCare card.

Estradiol FAQs

Medically reviewed by Gerardo SisonPharm.D.
Licensed Pharmacist

How much does Estradiol cost without insurance?

Estradiol may cost an average retail price of $188.97 for 1, 42.5gm of 0.1mg/gm tube of cream for 1, 42.5gm of 0.1mg/gm tube of cream. However, the price can vary if you do not have insurance coverage, depending on the dosage and quantity prescribed. Using a SingleCare Estradiol coupon may help you save on your prescription medication. Pay only $32.51 for 1, 42.5gm of 0.1mg/gm tube of cream when you use your discount card at participating pharmacies.

How much does Estradiol cost with insurance?

The cost of Estradiol with insurance may vary based on the type of health insurance plan you're enrolled in and the coverage it provides. Contact your insurance provider directly to find out how much Estradiol costs under your current insurance plan. Even with insurance coverage, you may have out-of-pocket costs to pay. 

Does Medicare cover Estradiol, and how much does it cost?

The cost of Estradiol with Medicare will vary based on the plan’s formulary, quantity prescribed, and the coverage stage. Refer to your plan’s drug formulary to find out whether your Medicare Part D or Medicare Advantage plan covers Estradiol and how much the copay or coinsurance is. If Estradiol is not covered by Medicare or if you have not met your plan’s deductible, you may have to pay the full cash price or higher out-of-pocket costs. 

What is the brand name of Estradiol?

Estradiol is a generic prescription drug that comes as an oral tablet, vaginal insert, vaginal cream, and topical emulsion, among other formulations. It is available under different brand names, depending on the formulation. Brand names of Estradiol oral tablets include Estrace and Yuvafem. Other estradiol formulations, such as patches, creams, and gels, are sold under brand names such as Vivelle-Dot, Climara, and Divigel. 

Ways to save on Estradiol

All formulations of Estradiol come in generic form, which costs less than the brand-name version. That includes tablets, gels, patches, and creams. Among these, oral Estradiol tablets are the least expensive.

Ways to save on a Estradiol prescription include:

  • Print or download a SingleCare discount card to save on your monthly Estradiol cost.

  • Ask your healthcare provider about samples. This isn’t a long-term solution, but it may help you get started to see how you respond to Estradiol.

  • Look into different health insurance options. Find out whether Estradiol is included in the formulary.

  • Check out the formulary for different Medicare Part D or Medicare Advantage plans.

Is there a cheaper alternative to Estradiol?

As a generic, there is no less expensive version of Estradiol. In general, tablets cost less than other forms, such as patches and creams. However, your healthcare provider will work with you to find the best formulation of Estradiol for your particular needs. They can also discuss non-hormone options that may work for certain symptoms.

Medically reviewed by Gerardo SisonPharm.D.
Licensed Pharmacist

Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.

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Where are Estradiol coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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