Estradiol works as a female hormone replacement therapy to increase estrogen levels and relieve symptoms of menopause. It can also be used for the prevention of osteoporosis and the palliative treatment of advanced-stage breast and prostate cancer. The average cost of oral Estradiol is $188.97 for 1, 42.5gm of 0.1mg/gm tube of cream. You may be able to purchase Estradiol at a price of $32.51 for 1, 42.5gm of 0.1mg/gm tube of cream with a SingleCare card.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
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Estradiol works as a female hormone replacement therapy to increase estrogen levels and relieve symptoms of menopause. It can also be used for the prevention of osteoporosis and the palliative treatment of advanced-stage breast and prostate cancer. The average cost of oral Estradiol is $188.97 for 1, 42.5gm of 0.1mg/gm tube of cream. You may be able to purchase Estradiol at a price of $32.51 for 1, 42.5gm of 0.1mg/gm tube of cream with a SingleCare card.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Estradiol Retail Price | Estradiol SingleCare Price |
|---|---|---|
| CVS Pharmacy | $112.20 | $67.90 |
| Walmart | $46.49 | $36.20 |
| Walgreens | $83.10 | $67.58 |
| Kroger Pharmacy | $306.82 | $84.99 |
| Albertsons Pharmacy | $122.83 | $42.92 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Estradiol works as a female hormone replacement therapy to increase estrogen levels and relieve symptoms of menopause. It can also be used for the prevention of osteoporosis and the palliative treatment of advanced-stage breast and prostate cancer. The average cost of oral Estradiol is $188.97 for 1, 42.5gm of 0.1mg/gm tube of cream. You may be able to purchase Estradiol at a price of $32.51 for 1, 42.5gm of 0.1mg/gm tube of cream with a SingleCare card.
Estradiol may cost an average retail price of $188.97 for 1, 42.5gm of 0.1mg/gm tube of cream for 1, 42.5gm of 0.1mg/gm tube of cream. However, the price can vary if you do not have insurance coverage, depending on the dosage and quantity prescribed. Using a SingleCare Estradiol coupon may help you save on your prescription medication. Pay only $32.51 for 1, 42.5gm of 0.1mg/gm tube of cream when you use your discount card at participating pharmacies.
The cost of Estradiol with insurance may vary based on the type of health insurance plan you're enrolled in and the coverage it provides. Contact your insurance provider directly to find out how much Estradiol costs under your current insurance plan. Even with insurance coverage, you may have out-of-pocket costs to pay.
The cost of Estradiol with Medicare will vary based on the plan’s formulary, quantity prescribed, and the coverage stage. Refer to your plan’s drug formulary to find out whether your Medicare Part D or Medicare Advantage plan covers Estradiol and how much the copay or coinsurance is. If Estradiol is not covered by Medicare or if you have not met your plan’s deductible, you may have to pay the full cash price or higher out-of-pocket costs.
Estradiol is a generic prescription drug that comes as an oral tablet, vaginal insert, vaginal cream, and topical emulsion, among other formulations. It is available under different brand names, depending on the formulation. Brand names of Estradiol oral tablets include Estrace and Yuvafem. Other estradiol formulations, such as patches, creams, and gels, are sold under brand names such as Vivelle-Dot, Climara, and Divigel.
All formulations of Estradiol come in generic form, which costs less than the brand-name version. That includes tablets, gels, patches, and creams. Among these, oral Estradiol tablets are the least expensive.
Ways to save on a Estradiol prescription include:
Print or download a SingleCare discount card to save on your monthly Estradiol cost.
Ask your healthcare provider about samples. This isn’t a long-term solution, but it may help you get started to see how you respond to Estradiol.
Look into different health insurance options. Find out whether Estradiol is included in the formulary.
Check out the formulary for different Medicare Part D or Medicare Advantage plans.
As a generic, there is no less expensive version of Estradiol. In general, tablets cost less than other forms, such as patches and creams. However, your healthcare provider will work with you to find the best formulation of Estradiol for your particular needs. They can also discuss non-hormone options that may work for certain symptoms.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved