What is Methazolamide: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Methazolamide overview

BRAND NAMES:

  • Neptazane

Generic Names:

  • Methazolamide

Uses:

  • Treats glaucoma. Belongs to a class of drugs called carbonic anhydrase inhibitors.

Therapeutic Classes:

  • Antiglaucoma, Cardiovascular Agent

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Methazolamide used for?

Neptazane is used to treat high pressure inside the eye caused by certain types of glaucoma. It works by reducing the activity of carbonic anhydrase, a protein in your body. Lower amounts of carbonic anhydrase decreases the production of fluid inside the eye, helping to prevent blindness, vision loss, and nerve damage.

What form(s) does Methazolamide come in

  • Tablet

What are common Methazolamide doses?

  • Tablet 25MG

  • Tablet 50MG

  • Bottle 1GM of

Common Methazolamide prescriptions

  • methazolAMIDE
    100 tablets bottle

  • methazolAMIDE
    25mg tablet

  • methazolAMIDE
    50mg tablet

How to take Methazolamide

  • Use this medicine exactly as your doctor ordered.

  • May be taken with or without food or milk.

  • You will need to go to the bathroom more often while you are using this medicine. To keep from having to go too often during the night, take this medicine in the morning. If you use more than 1 dose a day, take your last dose before 6 p.m. (unless your doctor tells you differently).

  • Use this medicine exactly as your doctor ordered.

  • May be taken with or without food or milk.

  • You will need to go to the bathroom more often while you are using this medicine. To keep from having to go too often during the night, take this medicine in the morning. If you use more than 1 dose a day, take your last dose before 6 p.m. (unless your doctor tells you differently).

What to do if you miss a dose of Methazolamide

  • You should not use two doses at the same time.

  • Use the missed dose as soon as you remember.

  • If it is almost time for your next dose, wait until then to use your medicine and skip the missed dose.

Methazolamide contraindications

  • You should not use this medicine if you have had an allergic reaction to methazolamide or related medicine such as acetazolamide (Diamox®) or dichlorphenamide (Daranide®).

Methazolamide warnings

  • Check with your doctor before using this medicine if you have lung, kidney, or liver disease, diabetes, gout, or a poorly working adrenal gland (Addison's disease).

  • Talk with your doctor before use if you are pregnant or breastfeeding.

  • Methazolamide can make you dizzy or drowsy. Be careful if you drive a car or operate machinery.

  • You may need to eat or drink foods containing potassium, such as citrus juices, oranges, or bananas, to prevent potassium loss while using this medicine. Check with your doctor.

  • This medicine may increase the level of sugar in your blood, which can worsen sugar diabetes.

  • Yellowing of skin or eyes

  • Severe nausea or vomiting

  • Unusual bleeding or bruising

  • Pain in joints or lower back

Methazolamide interactions

  • Make sure your doctor knows if you are using aspirin, amphetamines (Dexedrine®), quinidine, or methenamine (Mandelamine®).

  • Talk with your doctor before use if you are pregnant or breastfeeding.

  • Methazolamide can make you dizzy or drowsy. Be careful if you drive a car or operate machinery.

  • You may need to eat or drink foods containing potassium, such as citrus juices, oranges, or bananas, to prevent potassium loss while using this medicine. Check with your doctor.

  • This medicine may increase the level of sugar in your blood, which can worsen sugar diabetes.

Methazolamide side effects

Serious Side Effects

  • Irregular heartbeat

  • Trouble breathing

  • Skin rash, hives, or itching

  • Painful urination

  • Bloody stools or urine

  • Yellowing of skin or eyes

  • Severe nausea or vomiting

  • Pain in joints or lower back

  • Unusual bleeding or bruising

Less Serious Side Effects

  • Numbness or tingling in hands, feet, or mouth

  • Dizziness, drowsiness, or lightheadedness

  • Appetite loss or a metallic taste in mouth

  • Nausea, vomiting, or diarrhea

  • Vision changes

  • Frequent urination

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