Prezista is an antiretroviral medicine used to treat human immunodeficiency virus (HIV-1) infection in adults and children aged 3 years and older. Prezista is a brand-name drug that contains darunavir, and it is classified as a protease inhibitor. This drug needs to be taken with ritonavir and other antiretroviral drugs for maximum effectiveness. A generic version of this drug has been approved by the FDA but may not yet be available. The average retail price of Prezista is about $2,573.67 for 30, 800mg tablets, but you may be able to save by using a Prezista coupon from SingleCare. The lowest price for SingleCare card users is currently $63.46 per 30, 800mg tablets of generic Prezista at participating pharmacies.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 05/04/2026
Prezista is an antiretroviral medicine used to treat human immunodeficiency virus (HIV-1) infection in adults and children aged 3 years and older. Prezista is a brand-name drug that contains darunavir, and it is classified as a protease inhibitor. This drug needs to be taken with ritonavir and other antiretroviral drugs for maximum effectiveness. A generic version of this drug has been approved by the FDA but may not yet be available. The average retail price of Prezista is about $2,573.67 for 30, 800mg tablets, but you may be able to save by using a Prezista coupon from SingleCare. The lowest price for SingleCare card users is currently $63.46 per 30, 800mg tablets of generic Prezista at participating pharmacies.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Darunavir Retail Price | Darunavir SingleCare Price |
|---|---|---|
| CVS Pharmacy | $1934.10 | $104.10 |
| Walmart | $60.90 | $60.90 |
| Walgreens | $1064.10 | $745.50 |
| Kroger Pharmacy | $2262.90 | $1701.00 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Prezista is an antiretroviral medicine used to treat human immunodeficiency virus (HIV-1) infection in adults and children aged 3 years and older. Prezista is a brand-name drug that contains darunavir, and it is classified as a protease inhibitor. This drug needs to be taken with ritonavir and other antiretroviral drugs for maximum effectiveness. A generic version of this drug has been approved by the FDA but may not yet be available. The average retail price of Prezista is about $2,573.67 for 30, 800mg tablets, but you may be able to save by using a Prezista coupon from SingleCare. The lowest price for SingleCare card users is currently $63.46 per 30, 800mg tablets of generic Prezista at participating pharmacies.
Without health insurance coverage, the cash price of Prezista can be around $2,573.67 for a standard supply. Luckily, you may be able to save by using a free Prezista coupon or prescription discount card from SingleCare. With SingleCare, you could pay a reduced price of $63.46 instead of the average retail price of $2,573.67.
Check with your insurance provider or pharmacist to calculate your copay with insurance coverage, as costs can vary by health plan. With a SingleCare prescription savings card, you may be able to save instantly and pay a reduced cost of $63.46 on your first prescription or refill of Prezista. SingleCare free coupons are free and easy to use, and customers may find that prescription costs with SingleCare are lower than the cost with insurance.
Medicare prescription drug insurance plans may cover Prezista, with copays that can range from $42 to$1866. The exact cost of Prezista with Medicare will vary depending on your plan and the quantity of medication prescribed. If you don’t have Medicare coverage or Medicare doesn’t cover the full cost of your prescription, you could save with a free coupon or discount card from SingleCare. You can use a free Prezista coupon or savings card from SingleCare at any local drugstore and save on your prescription costs. With SingleCare, you may end up paying $63.46 instead of $2,573.67.
Prezista is a brand-name prescription drug that is manufactured by Janssen Pharmaceuticals, Inc. A generic version of Prezista, darunavir, has been approved by the FDA but may not yet be available on the market.
Prezista is used to treat HIV-1 infection, an infection that can cause acquired immunodeficiency syndrome (AIDS) if left untreated. Prezista is a brand-name drug that contains darunavir. It works as a protease inhibitor that helps slow the growth and spread of the virus throughout the body. Prezista is not a cure for HIV infection and it must be given with other medications, such as cobicistat or ritonavir, to effectively reduce HIV levels in the body. Reducing the amount of HIV (viral load) in the blood can help improve the immune system and reduce the risk of complications from HIV, such as serious infections.
Tell your doctor if you have a history of liver problems, including hepatitis B or hepatitis C, sulfa medication allergies, diabetes, hemophilia, or other medical conditions before taking Prezista. You should also tell your doctor if you are pregnant or breastfeeding before taking Prezista. If you are taking other medications, including prescription drugs, over-the-counter medicines, and herbal supplements, you should advise your doctor since other medications may interact with Prezista.
Take Prezista as prescribed. This medication is usually taken on a daily basis with food. You should not stop taking Prezista or change the dosage without guidance from your healthcare provider.
The most common side effects of Prezista are nausea, vomiting, diarrhea, headache, rash, and abdominal or stomach pain. Other side effects may include fatigue, abnormal dreams, itching, and indigestion.
Serious side effects may include high blood sugar levels (hyperglycemia), body fat changes, immune system changes (immune reconstitution syndrome), and, in people with hemophilia, increased bleeding problems. Liver damage and severe skin reactions have also been reported while using Prezista. Tell your doctor if side effects develop, persist, or worsen while taking Prezista.
This is not a complete list of side effects. Consult your doctor or healthcare professional for additional information and medical advice regarding other possible side effects or drug interactions. You can report unlisted side-effects to the FDA.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved