How long does trazodone last in dogs?

Trazodone, an FDA-approved human medicine used to reduce the symptoms of stress, anxiety, and depression in people, is available as “extra-label” or off-label use through veterinary medicine for the treatment of pets. With minimal potential side effects, trazodone used to treat dogs could be a good choice for short-term or long-term management of anxiety.

Dr. Ray Spragley DVM CVA CCRT, a veterinarian at Zen Dog Veterinarian Care states, “Trazodone is a serotonin antagonist and reuptake inhibitor (SARI). This means it will increase levels of serotonin in a dog’s brain to combat anxiety and make them more relaxed. Since trazodone is a very safe medication, it has a large range of doses that can be given.“ A dose of trazodone for dogs generally lasts about 6 to 12 hours. Spragley continues to say, “For most dogs, it will make them more subdued and a bit tired.”

How long will trazodone last in dogs?

The duration of trazodone in a dog’s system can change based on several variants. Factors such as the dog’s general health, metabolism, age, and any other pre-existing conditions should be considered. When used for short-term stress relief, dog owners can expect to see the effects of trazodone within 30 minutes to one hour after it’s given. Although the medicine will absorb faster on an empty stomach, pet parents can give the medicine with a small treat to avoid potential stomach irritation. 

Specific situations such as car rides, veterinary visits, and loud noises like thunderstorms or fireworks, could be causes for giving anti-anxiety medication to dogs. To help reduce stress and behavioral issues associated with fear, trazodone could be provided on an as-needed basis or long-term. If a low dose of trazodone is taken daily, the medication may need several weeks before the dog fully acclimates to the medicine. 

When is the peak time for trazodone for dogs?

It is useful to know about a medication’s peak level and half-life, especially if medication is needed for situational anxiety, preparation for surgery, or other time-sensitive matters.

When a medication is at its peak, the drug is at its highest level or maximum effect on the dog/patient. Peak levels can vary from dog to dog, depending on the pet’s metabolism rate, weight, hydration level, and age. Food can also slow down the absorption of the medication. Administering medicine 1 to 2 hours after eating can increase the absorption rate of trazodone. 

The medication’s half-life represents the time needed for half or 50% of the medication to be eliminated from the body. Dr. Sabrina Kong DVM and contributor to welovedoodles.com explains, “Generally, trazodone has a half-life of approximately 3 to 6 hours in dogs, which means the medication’s concentration in the blood is reduced by half during this time.” For example, the half-life of trazodone is approximately 4 hours, and 50% of the drug has been used up by the body after 4 hours. Another half will reduce this amount after an additional 4 hours until the medication is completely removed from the dog’s system. Kong further notes, “The medication can last up to 24 hours, depending on the individual dog and the dose administered.”

Trazodone is a short-acting medication and your veterinarian will tell you the appropriate amount and time to administer anxiety medications in preparation for surgery or other uses. Because of its sedative effects, this medication is often used post-surgery during the recovery period as well. When used for anxiety-related disorders or behavioral disorders, it is best to give trazodone 1 to 2 hours before a stressful event such as vet visits or fireworks. Doing so allows the medicine to be in full effect when the dog needs it the most. 

How long does it take for trazodone to wear off in dogs?

Trazodone comes in scored tablets of 50 mg, 100 mg, 150 mg, and 300 mg. Pills can be split in half to allow for various doses, especially for small dogs or dogs with severe anxiety that may need multiple doses throughout the day. In addition, trazodone hydrochloride (HCL) is available compounded in liquid form specially formulated for dogs. 

Trazodone works as a short-acting drug and typically wears off within 6 to 12 hours after it is given for situational anxiety. Short-term use of trazodone should be completely out of the system within 24 hours but may take longer if used for long-term management of anxiety. Weight, age, and the general health of the pet can also be taken into consideration when assessing how long a trazodone dosage wears off. 

Can you give a dog too much trazodone?

A dog can consume too much trazodone and overdose. An overdose of trazodone could lead to excessive serotonin levels, also known as serotonin syndrome. Signs of serotonin syndrome may include restless, disoriented, agitated, pacing, or an increased heart rate. While it is not a common side effect, in some cases, seizures occur. 

The most common side effects of trazodone in dogs include nausea, vomiting, diarrhea, dizziness, lack of coordination, lethargy, and sedation. In addition, dogs may experience increased appetite, excess saliva, panting, and dilated pupils as a response to trazodone medication. Look for signs of overdose and seek medical advice if the trazodone side effects seem extreme. Your veterinarian may suggest a lower dose or alternative medication.

Trazodone for dogs is the same as for human use, but only give your dog trazodone under a veterinarian’s instructions. Elderly dogs may have an increased risk for adverse effects. Too much trazodone could cause hepatotoxicity or liver damage. Dogs that have kidney disease, liver disease, or heart disease may not be recommended to take trazodone. Owners of dogs should convey all medical history, including other medications the dog is taking, to the veterinarian to avoid negative side effects. If your dog becomes pregnant, seek medical advice from your vet as trazodone could have adverse effects on the developing fetus.

Can I stop giving my dog trazodone?

To avoid an adverse reaction, do not abruptly discontinue the use of your dog’s long-term anxiety medicine. However, in some cases, such as an allergic reaction, suspected overdose, or immediate health concerns, your veterinarian may recommend immediate termination of trazodone. Withdrawal symptoms such as a spike in anxiety symptoms, trouble sleeping, and agitation could occur if medication is not tapered.

Dr. Sabrina Kong DVM further suggests, “The best approach to weaning off trazodone involves gradually reducing the dose over time, allowing the dog’s body to adjust without causing undue stress. The specific weaning schedule will depend on the dog’s individual response to the medication, how long they have been taking it, and their overall health status.” Consult your medical provider and follow the vet’s instructions to discontinue the use of trazodone safely. 

In addition to prescription medication, natural products and holistic practices such as additional exercise or training sessions could play an important role in reducing behavioral issues associated with stress. Homeopathic remedies such as chamomile, lavender, or melatonin could also help ease an anxious canine. A combination of treatments is often recommended to reduce pet anxiety.