What is Cetirizine-Pseudoephedrine ER: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Cetirizine-Pseudoephedrine ER overview

BRAND NAMES:

  • ZyrTEC-D, ZyrTEC-D, Allergy Relief Nasal Decongestant, Cetiri-D, Good Neighbor Pharmacy All Day Allergy-D, Good Sense All Day Allergy-D, Health Mart Allergy Complete-D, Leader All Day Allergy D-12, Leader Allergy Relief-D, TopCare All Day Allergy D

Generic Names:

  • Cetirizine-Pseudoephedrine Er

Uses:

  • Treats allergy symptoms (watery eyes, runny or stuffy nose). This medicine is a combination of an antihistamine and a decongestant.

Therapeutic Classes:

  • Antihistamine/Decongestant Combination

Forms:

  • Long Acting Tablet

How it’s taken:

  • By mouth

What is Cetirizine-Pseudoephedrine ER used for?

What form(s) does Cetirizine-Pseudoephedrine ER come in

  • Long Acting Tablet

What are common Cetirizine-Pseudoephedrine ER doses?

  • Box 12 Tablets Extended Release 12 Hour

  • Box 24 Tablets Extended Release 12 Hour

Common Cetirizine-Pseudoephedrine ER prescriptions

  • Cetirizine-Pseudoephedrine ER
    12 tablets extended release 12 hour box

  • Cetirizine-Pseudoephedrine ER
    24 tablets extended release 12 hour box

  • Cetirizine-Pseudoephedrine ER
    5-120mg, 12 tablets er 12 hour box

  • Cetirizine-Pseudoephedrine ER
    5-120mg, 24 tablets er 12 hour box

How to take Cetirizine-Pseudoephedrine ER

  • You may take this medicine with or without food.

  • Swallow the tablet whole. Do not crush, break, or chew the tablet.

  • Your doctor will tell you how much of this medicine to take and how often. Do not take more medicine or take it more often than your doctor tells you to.

  • Never share your medicine with anyone.

  • Never share your medicine with anyone.

  • Swallow the tablet whole. Do not crush, break, or chew the tablet.

  • Your doctor will tell you how much of this medicine to take and how often. Do not take more medicine or take it more often than your doctor tells you to.

  • You may take this medicine with or without food.

What to do if you miss a dose of Cetirizine-Pseudoephedrine ER

  • If you miss a dose or forget to take your medicine, take it as soon as you can. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose.

  • Do not use extra medicine to make up for a missed dose.

  • Keep all medicine away from children.

Cetirizine-Pseudoephedrine ER contraindications

  • You should not use this medicine if you have had an allergic reaction to cetirizine, pseudoephedrine, or hydroxyzine (Atarax®, Vistaril®), or if you have narrow-angle glaucoma, trouble urinating, very high blood pressure, or severe heart disease. You should not use this medicine if you have used an MAO inhibitor (Eldepryl®, Marplan®, Nardil®, Parnate®) within the past 14 days, or if you have had a drug reaction that involved trouble sleeping, dizziness, weakness, shaking, or changes in your heart rhythm. Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years old. Using these medicines in very young children might cause serious or possibly life-threatening side effects.

Cetirizine-Pseudoephedrine ER warnings

  • Yellow skin or eyes

  • Unusual behavior

  • Seizures

  • Severe restlessness, nervousness, dizziness, or trouble sleeping

  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

  • Dark-colored urine or pale stools

  • Nausea, vomiting, loss of appetite, pain in the upper stomach

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, high blood pressure, diabetes, heart disease, high pressure inside your eye, overactive thyroid, problems with urination, or prostate problems, or if you are on dialysis.

Cetirizine-Pseudoephedrine ER interactions

  • Make sure your doctor knows if you are also using theophylline, digoxin (Lanoxin®), or blood pressure medicine (such as methyldopa, Aldomet®, mecamylamine, Inversine®, reserpine, Serpasil®).

  • Make sure your doctor knows if you are using any medicines that make you sleepy (such as sleeping pills, other cold and allergy medicine, narcotic pain relievers, or sedatives). Do not drink alcohol while you are using this medicine.

Cetirizine-Pseudoephedrine ER side effects

Serious Side Effects

  • Nausea, vomiting, loss of appetite, pain in the upper stomach

  • Unusual behavior

  • Severe restlessness, nervousness, dizziness, or trouble sleeping

  • Chest pain, fast heartbeat, lightheadedness or fainting

  • Dark-colored urine or pale stools

  • Allergic reaction: Itching or hives, swelling in face or hands, swelling or tingling in the mouth or throat, tightness in chest, trouble breathing

  • Yellow skin or eyes

  • Seizures

Less Serious Side Effects

  • Dry mouth

  • Change in how much or how often you urinate

  • Sleepiness, tiredness