What is Indomethacin Sodium? Uses, warnings & side effects

Updated May 14, 2025  •  Published Apr 11, 2021

Indomethacin Sodium overview

BRAND NAMES:

  • Indomethacin Novaplus, PremierPro Rx Indomethacin

Generic Names:

  • Indomethacin Sodium

Uses:

  • Used in premature babies born with heart disease such as patent ductus arteriosus.

Therapeutic Classes:

  • Analgesic, Central Nervous System Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Indomethacin Sodium used for?

What form(s) does Indomethacin Sodium come in?

  • Injectable

What are common Indomethacin Sodium dosages?

  • Solution Reconstituted 1MG

How to take Indomethacin Sodium

  • This medicine is given to your child through a needle placed in one of the veins.

  • A nurse or other trained health professional will give this medicine.

What to do if you miss a dose of Indomethacin Sodium

Indomethacin Sodium contraindications - Who shouldn't take Indomethacin Sodium?

  • Your child should not receive this medicine if he or she has had an allergic reaction to indomethacin, or if your child has an untreated infection, kidney problems, or certain intestinal problems or bleeding problems. Your child should not receive this medicine if he or she has congenital heart disease such as pulmonary atresia, severe tetralogy of Fallot, or severe coarctation of the aorta.

Indomethacin Sodium warnings

  • Make sure your doctor knows if your child has kidney disease, a bleeding disorder, or bleeding in the brain, stomach, or intestines.

  • Make sure your child's doctor knows if your child has any infection or liver disease.

  • Decrease in number of wet diapers each day.

  • Drowsiness or seizures.

  • Severe vomiting or bloated belly.

  • Trouble breathing.

  • Uneven or slow heart beat.

  • Unusual bleeding, or bruising.

Indomethacin Sodium interactions & what to avoid when taking Indomethacin Sodium

  • Make sure your child's doctor knows all the medicines your child is receiving such as furosemide (Lasix®), digitalis (Digitek®, Lanoxin®) or medicines to treat an infection such as amikacin or gentamicin.

  • Make sure your child's doctor knows if your child has any infection or liver disease.

Indomethacin Sodium side effects - How does Indomethacin Sodium make you feel?

Serious Side Effects

  • Uneven or slow heart beat.

  • Drowsiness or seizures.

  • Severe vomiting or bloated belly.

  • Blood in your child's stools.

  • Bluish-colored skin.

  • Decrease in number of wet diapers each day.

  • Trouble breathing.

  • Unusual bleeding, or bruising.

Less Serious Side Effects

  • Mild vomiting.

  • Mild skin rash.

  • Fever.

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