Otezla is an oral prescription drug used to treat adults with moderate to severe plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet's Disease. There is a generic version of Otezla available called aprelimast. On average, you could pay a retail price of $6,637.72 for 60, 30mg tablets. To save on Otezla costs, you may be able to use a free Otezla coupon from SingleCare, which is accepted at participating pharmacies nationwide.
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Los precios de los medicamentos recetados de SingleCare se basan en diversas fuentes. Los precios que publicamos son nuestra mejor estimación, pero no podemos garantizar que el precio que mostramos coincida exactamente con el precio que recibes en la farmacia. Para saber el precio exacto, por favor, comunícate con tu farmacia y proporciona los números BIN/GRP/PCN que aparecen en tu tarjeta de SingleCare.
Cualquier bono de ahorro de Single Care, incluyendo el bono de $3 de inscripción, puede usarse solo (or solamente) una vez.
Precios actualizados: 21/12/2025
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Otezla is an oral prescription drug used to treat adults with moderate to severe plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet's Disease. There is a generic version of Otezla available called aprelimast. On average, you could pay a retail price of $6,637.72 for 60, 30mg tablets. To save on Otezla costs, you may be able to use a free Otezla coupon from SingleCare, which is accepted at participating pharmacies nationwide.
Nuestras métricas de historial de precios son calculadas a partir de datos agregados de las recetas médicas que recibimos de todas las farmacias participantes. Esta tabla se actualiza diariamente para mostrar las nuevas variaciones en los precios. Si falta un punto de datos en la tabla, es porque no contamos con suficiente información para producir una cifra confiable.
| Farmacia | de venta promedio de Otezla | Precio de Otezla en SingleCare |
|---|---|---|
| Walgreens | $6396.60 | $5370.60 |
| Kroger Pharmacy | $6388.20 | $4876.20 |
Estos precios se basan en los datos del último mes de surtidos de recetas de SingleCare en las principales farmacias. Esta tabla se actualiza diariamente para mostrar los precios típicos más precisos por farmacia. Si falta algún dato en la tabla, es porque no contamos con suficiente información para generar una cifra confiable.
Otezla is an oral prescription drug used to treat adults with moderate to severe plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet's Disease. There is a generic version of Otezla available called aprelimast. On average, you could pay a retail price of $6,637.72 for 60, 30mg tablets. To save on Otezla costs, you may be able to use a free Otezla coupon from SingleCare, which is accepted at participating pharmacies nationwide.
Without insurance, the average retail cost of Otezla is $6,637.72 for 60, 30mg tablets. The cash price of Otezla can vary depending on the quantity purchased and the pharmacy location where it is purchased. Otezla can be an expensive prescription. Fortunately, SingleCare offers Otezla coupons to help save on the cash price of medications. You could pay only $4,873.49 for 60, 30mg tablets at a participating pharmacy with a SingleCare card. You may need to purchase Otezla from a specialty pharmacy.
Insurance copay costs for Otezla can vary by insurance plan, coverage stage, and quantity prescribed. Contact your health insurance company to determine your cost for Otezla with insurance coverage. You can also check your insurance plan’s formulary to see if they will cover Otezla. In some cases, SingleCare may offer better savings than your insurance plan. To determine the best payment option, ask your pharmacist to apply your SingleCare discount card and compare Otezla prices.
Most Medicare prescription plans cover Otezla. However, costs with Medicare will vary by plan, prescription, and coverage stage. Refer to your plan’s drug formulary to find out whether your Medicare Part D or Medicare Advantage plan covers Otezla and how much the copay or coinsurance is. If you have not met your deductible, you may have to pay the full out-of-pocket costs for Otezla. Alternatively, a SingleCare savings card can help you access this prescription drug at a reduced cash price of $4,873.49 for 60, 30mg tablets.
Otezla is available as a brand-name drug, as well as a generic version called apremilast.
Otezla (apremilast) is a prescription medication approved for treating:
Plaque psoriasis in adults who are candidates for phototherapy or systemic therapy
Adults with active psoriatic arthritis
Oral ulcers associated with Behçet's Disease
Otezla is FDA-approved for use in adults only and is not approved for use in people under the age of 18 years.
Otezla is a PDE4 inhibitor that works inside inflammatory cells to reduce PDE4 activity. Decreased PDE4 activity is believed to help reduce the inflammation that occurs in people with psoriatic disease. Reducing inflammation in the body may help lessen certain symptoms, such as redness, swelling, and pain.
Otezla is usually taken twice daily. Treatment with Otezla is usually started at a low dose and then increased gradually to reduce the risk of gastrointestinal side effects. Otezla should only be taken as prescribed by a healthcare provider.
The most common side effects of Otezla include headache, diarrhea, and nausea. However, side effects often go away on their own as the body adjusts to the medication. Other potential side effects include upper respiratory tract infections, fatigue, vomiting, decreased appetite, weight loss, insomnia, and back pain.
Serious side effects of {{drug}} include allergic reactions. Seek immediate medical attention if you experience signs or symptoms of an allergic reaction, such as hives, itching, swelling of the face or throat, or trouble breathing. Other serious side effects may include severe vomiting and severe diarrhea.
Tell your doctor or healthcare provider if you have a history of depression before taking Otezla. The use of Otezla has been reported to cause worsened symptoms of depression, suicidal thoughts, or other changes in mood. You should also tell your healthcare provider about other medical conditions you may have, including kidney disease.
Before taking Otezla, tell your healthcare provider about all the medications you take. Tell your healthcare provider if you take certain seizure medication, such as carbamazepine, phenobarbital, or phenytoin—or a drug called rifampin used to treat tuberculosis. These medications can decrease the effectiveness of Otezla.
Tell your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before taking Otezla.
This is not a complete list of side effects associated with Otezla. Consult a healthcare provider for more information about other possible adverse effects, drug interactions, warnings, and precautions before starting treatment with Otezla.
Weight loss has been reported in clinical trials of Otezla. A decrease in weight of 5% to 10% was reported in some patients taking Otezla. Body weight may need to be monitored regularly while taking Otezla. Tell your healthcare provider if you experience unexpected weight loss while taking Otezla.
Otezla is available in two-week and 28-day starter packs. The dosage of Otezla needs to be gradually increased to reduce the risk of gastrointestinal side effects, such as diarrhea, nausea, and vomiting.
Your healthcare provider may give you a 14-day starter pack. Or, they may prescribe the 28-day starter pack through a specialty pharmacy.
The two-week and 28-day starter parks contain a titration pack plus enough 30 mg tablets for one or three additional weeks of treatment. The initial blister titration pack in each starter pack lasts a total of seven days. It contains the tablets needed to gradually increase the dosage of Otezla to 30 mg twice daily. This schedule helps reduce stomach problems.
The titration schedule is as follows:
Day 1: 10 mg in the morning
Day 2: 10 mg in the morning and 10 mg in the evening
Day 3: 10 mg in the morning and 20 mg in the evening
Day 4: 20 mg in the morning and 20 mg in the evening
Day 5: 20 mg in the morning and 30 mg in the evening
Day 6 and onward: 30 mg twice daily
Otezla and Humira are not the same. Otezla is an oral medication that can treat psoriatic arthritis, plaque psoriasis, and oral ulcers associated with Behçet’s Disease.
Humira is an injectable medicine. Like Otezla, it can treat psoriatic arthritis and plaque psoriasis but not oral ulcers associated with Behçet’s Disease. Humira also can treat many other conditions, such as rheumatoid arthritis, Crohn’s disease, uveitis, and others.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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