Otezla Coupons & Prices

Otezla is an oral prescription drug used to treat adults with moderate to severe plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet's Disease. There is a generic version of Otezla available called aprelimast. On average, you could pay a retail price of $6,637.74 for 60, 30mg tablets. To save on Otezla costs, you may be able to use a free Otezla coupon from SingleCare, which is accepted at participating pharmacies nationwide.

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Otezla coupon at Kroger Pharmacy
$4876.49
$ 4,873
$3 off with signupwith signup

Show this free card to your pharmacist.

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Otezla coupon at Harris Teeter Pharmacy
$4876.49
$ 4,873
$3 off with signupwith signup

Save an extra $3 on any eligible prescription! Sign up for free

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Otezla coupon at Walgreens Pharmacy
$4931.11
$ 4,928
$3 off with signupwith signup
Otezla coupon at Publix Pharmacy
$5296.43
$ 5,293
$3 off with signupwith signup
Otezla coupon at Costco Pharmacy
$5357.32
$ 5,354
$3 off with signupwith signup
Otezla coupon at Food Lion Pharmacy
$ 5,438

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

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About Otezla

Otezla is an oral prescription drug used to treat adults with moderate to severe plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet's Disease. There is a generic version of Otezla available called aprelimast. On average, you could pay a retail price of $6,637.74 for 60, 30mg tablets. To save on Otezla costs, you may be able to use a free Otezla coupon from SingleCare, which is accepted at participating pharmacies nationwide.

Otezla Price History & Information

Price History for Otezla

60 count, disp pack, 28 tablets

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Otezla

60 count, disp pack, 28 tablets
PharmacyOtezla Retail PriceOtezla SingleCare Price
Walgreens$6396.60$5370.60
Kroger Pharmacy$6388.20$4876.20

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Otezla

Otezla is an oral prescription drug used to treat adults with moderate to severe plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet's Disease. There is a generic version of Otezla available called aprelimast. On average, you could pay a retail price of $6,637.74 for 60, 30mg tablets. To save on Otezla costs, you may be able to use a free Otezla coupon from SingleCare, which is accepted at participating pharmacies nationwide.

Otezla FAQs

Medically reviewed by Karen BergerPharm.D.
Licensed Pharmacist

How much does Otezla cost without insurance?

Without insurance, the average retail cost of Otezla is $6,637.74 for 60, 30mg tablets. The cash price of Otezla can vary depending on the quantity purchased and the pharmacy location where it is purchased. Otezla can be an expensive prescription. Fortunately, SingleCare offers Otezla coupons to help save on the cash price of medications. You could pay only $4,873.49 for 60, 30mg tablets at a participating pharmacy with a SingleCare card. You may need to purchase Otezla from a specialty pharmacy.

How much does Otezla cost with insurance?

Insurance copay costs for Otezla can vary by insurance plan, coverage stage, and quantity prescribed. Contact your health insurance company to determine your cost for Otezla with insurance coverage. You can also check your insurance plan’s formulary to see if they will cover Otezla. In some cases, SingleCare may offer better savings than your insurance plan. To determine the best payment option, ask your pharmacist to apply your SingleCare discount card and compare Otezla prices.

Does Medicare cover Otezla and how much does it cost?

Most Medicare prescription plans cover Otezla. However, costs with Medicare will vary by plan, prescription, and coverage stage. Refer to your plan’s drug formulary to find out whether your Medicare Part D or Medicare Advantage plan covers Otezla and how much the copay or coinsurance is. If you have not met your deductible, you may have to pay the full out-of-pocket costs for Otezla. Alternatively, a SingleCare savings card can help you access this prescription drug at a reduced cash price of $4,873.49 for 60, 30mg tablets.

Is there a generic of Otezla?

Otezla is available as a brand-name drug, as well as a generic version called apremilast.

What is Otezla?

Otezla (apremilast) is a prescription medication approved for treating:

  • Plaque psoriasis in adults who are candidates for phototherapy or systemic therapy

  • Adults with active psoriatic arthritis

  • Oral ulcers associated with Behçet's Disease

Otezla is FDA-approved for use in adults only and is not approved for use in people under the age of 18 years.

Otezla is a PDE4 inhibitor that works inside inflammatory cells to reduce PDE4 activity. Decreased PDE4 activity is believed to help reduce the inflammation that occurs in people with psoriatic disease. Reducing inflammation in the body may help lessen certain symptoms, such as redness, swelling, and pain. 

Otezla is usually taken twice daily. Treatment with Otezla is usually started at a low dose and then increased gradually to reduce the risk of gastrointestinal side effects. Otezla should only be taken as prescribed by a healthcare provider. 

What are the side effects of Otezla?

The most common side effects of Otezla include headache, diarrhea, and nausea. However, side effects often go away on their own as the body adjusts to the medication. Other potential side effects include upper respiratory tract infections, fatigue, vomiting, decreased appetite, weight loss, insomnia, and back pain. 

Serious side effects of {{drug}} include allergic reactions. Seek immediate medical attention if you experience signs or symptoms of an allergic reaction, such as hives, itching, swelling of the face or throat, or trouble breathing. Other serious side effects may include severe vomiting and severe diarrhea.

Tell your doctor or healthcare provider if you have a history of depression before taking Otezla. The use of Otezla has been reported to cause worsened symptoms of depression, suicidal thoughts, or other changes in mood. You should also tell your healthcare provider about other medical conditions you may have, including kidney disease. 

Before taking Otezla, tell your healthcare provider about all the medications you take. Tell your healthcare provider if you take certain seizure medication, such as carbamazepine, phenobarbital, or phenytoin—or a drug called rifampin used to treat tuberculosis. These medications can decrease the effectiveness of Otezla. 

Tell your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before taking Otezla. 

This is not a complete list of side effects associated with Otezla. Consult a healthcare provider for more information about other possible adverse effects, drug interactions, warnings, and precautions before starting treatment with Otezla.

Does Otezla cause weight loss?

Weight loss has been reported in clinical trials of Otezla. A decrease in weight of 5% to 10% was reported in some patients taking Otezla. Body weight may need to be monitored regularly while taking Otezla. Tell your healthcare provider if you experience unexpected weight loss while taking Otezla. 

How long does Otezla starter pack last?

Otezla is available in two-week and 28-day starter packs. The dosage of Otezla needs to be gradually increased to reduce the risk of gastrointestinal side effects, such as diarrhea, nausea, and vomiting. 

Your healthcare provider may give you a 14-day starter pack. Or, they may prescribe the 28-day starter pack through a specialty pharmacy.

The two-week and 28-day starter parks contain a titration pack plus enough 30 mg tablets for one or three additional weeks of treatment. The initial blister titration pack in each starter pack lasts a total of seven days. It contains the tablets needed to gradually increase the dosage of Otezla to 30 mg twice daily. This schedule helps reduce stomach problems. 

The titration schedule is as follows:

  • Day 1: 10 mg in the morning

  • Day 2: 10 mg in the morning and 10 mg in the evening

  • Day 3: 10 mg in the morning and 20 mg in the evening

  • Day 4: 20 mg in the morning and 20 mg in the evening

  • Day 5: 20 mg in the morning and 30 mg in the evening

  • Day 6 and onward: 30 mg twice daily

Is Otezla the same as Humira?

Otezla and Humira are not the same. Otezla is an oral medication that can treat psoriatic arthritis, plaque psoriasis, and oral ulcers associated with Behçet’s Disease. 

Humira is an injectable medicine. Like Otezla, it can treat psoriatic arthritis and plaque psoriasis but not oral ulcers associated with Behçet’s Disease. Humira also can treat many other conditions, such as rheumatoid arthritis, Crohn’s disease, uveitis, and others.

Medically reviewed by Karen BergerPharm.D.
Licensed Pharmacist

After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.

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Where are Otezla coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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