Otezla is an oral prescription drug used to treat adults with moderate to severe plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet's Disease. There is a generic version of Otezla available called aprelimast. On average, you could pay a retail price of $6,637.74 for 60, 30mg tablets. To save on Otezla costs, you may be able to use a free Otezla coupon from SingleCare, which is accepted at participating pharmacies nationwide.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Otezla is an oral prescription drug used to treat adults with moderate to severe plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet's Disease. There is a generic version of Otezla available called aprelimast. On average, you could pay a retail price of $6,637.74 for 60, 30mg tablets. To save on Otezla costs, you may be able to use a free Otezla coupon from SingleCare, which is accepted at participating pharmacies nationwide.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Otezla Retail Price | Otezla SingleCare Price |
|---|---|---|
| Walgreens | $6396.60 | $5370.60 |
| Kroger Pharmacy | $6388.20 | $4876.20 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Otezla is an oral prescription drug used to treat adults with moderate to severe plaque psoriasis, psoriatic arthritis, and oral ulcers associated with Behçet's Disease. There is a generic version of Otezla available called aprelimast. On average, you could pay a retail price of $6,637.74 for 60, 30mg tablets. To save on Otezla costs, you may be able to use a free Otezla coupon from SingleCare, which is accepted at participating pharmacies nationwide.
Without insurance, the average retail cost of Otezla is $6,637.74 for 60, 30mg tablets. The cash price of Otezla can vary depending on the quantity purchased and the pharmacy location where it is purchased. Otezla can be an expensive prescription. Fortunately, SingleCare offers Otezla coupons to help save on the cash price of medications. You could pay only $4,873.49 for 60, 30mg tablets at a participating pharmacy with a SingleCare card. You may need to purchase Otezla from a specialty pharmacy.
Insurance copay costs for Otezla can vary by insurance plan, coverage stage, and quantity prescribed. Contact your health insurance company to determine your cost for Otezla with insurance coverage. You can also check your insurance plan’s formulary to see if they will cover Otezla. In some cases, SingleCare may offer better savings than your insurance plan. To determine the best payment option, ask your pharmacist to apply your SingleCare discount card and compare Otezla prices.
Most Medicare prescription plans cover Otezla. However, costs with Medicare will vary by plan, prescription, and coverage stage. Refer to your plan’s drug formulary to find out whether your Medicare Part D or Medicare Advantage plan covers Otezla and how much the copay or coinsurance is. If you have not met your deductible, you may have to pay the full out-of-pocket costs for Otezla. Alternatively, a SingleCare savings card can help you access this prescription drug at a reduced cash price of $4,873.49 for 60, 30mg tablets.
Otezla is available as a brand-name drug, as well as a generic version called apremilast.
Otezla (apremilast) is a prescription medication approved for treating:
Plaque psoriasis in adults who are candidates for phototherapy or systemic therapy
Adults with active psoriatic arthritis
Oral ulcers associated with Behçet's Disease
Otezla is FDA-approved for use in adults only and is not approved for use in people under the age of 18 years.
Otezla is a PDE4 inhibitor that works inside inflammatory cells to reduce PDE4 activity. Decreased PDE4 activity is believed to help reduce the inflammation that occurs in people with psoriatic disease. Reducing inflammation in the body may help lessen certain symptoms, such as redness, swelling, and pain.
Otezla is usually taken twice daily. Treatment with Otezla is usually started at a low dose and then increased gradually to reduce the risk of gastrointestinal side effects. Otezla should only be taken as prescribed by a healthcare provider.
The most common side effects of Otezla include headache, diarrhea, and nausea. However, side effects often go away on their own as the body adjusts to the medication. Other potential side effects include upper respiratory tract infections, fatigue, vomiting, decreased appetite, weight loss, insomnia, and back pain.
Serious side effects of {{drug}} include allergic reactions. Seek immediate medical attention if you experience signs or symptoms of an allergic reaction, such as hives, itching, swelling of the face or throat, or trouble breathing. Other serious side effects may include severe vomiting and severe diarrhea.
Tell your doctor or healthcare provider if you have a history of depression before taking Otezla. The use of Otezla has been reported to cause worsened symptoms of depression, suicidal thoughts, or other changes in mood. You should also tell your healthcare provider about other medical conditions you may have, including kidney disease.
Before taking Otezla, tell your healthcare provider about all the medications you take. Tell your healthcare provider if you take certain seizure medication, such as carbamazepine, phenobarbital, or phenytoin—or a drug called rifampin used to treat tuberculosis. These medications can decrease the effectiveness of Otezla.
Tell your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before taking Otezla.
This is not a complete list of side effects associated with Otezla. Consult a healthcare provider for more information about other possible adverse effects, drug interactions, warnings, and precautions before starting treatment with Otezla.
Weight loss has been reported in clinical trials of Otezla. A decrease in weight of 5% to 10% was reported in some patients taking Otezla. Body weight may need to be monitored regularly while taking Otezla. Tell your healthcare provider if you experience unexpected weight loss while taking Otezla.
Otezla is available in two-week and 28-day starter packs. The dosage of Otezla needs to be gradually increased to reduce the risk of gastrointestinal side effects, such as diarrhea, nausea, and vomiting.
Your healthcare provider may give you a 14-day starter pack. Or, they may prescribe the 28-day starter pack through a specialty pharmacy.
The two-week and 28-day starter parks contain a titration pack plus enough 30 mg tablets for one or three additional weeks of treatment. The initial blister titration pack in each starter pack lasts a total of seven days. It contains the tablets needed to gradually increase the dosage of Otezla to 30 mg twice daily. This schedule helps reduce stomach problems.
The titration schedule is as follows:
Day 1: 10 mg in the morning
Day 2: 10 mg in the morning and 10 mg in the evening
Day 3: 10 mg in the morning and 20 mg in the evening
Day 4: 20 mg in the morning and 20 mg in the evening
Day 5: 20 mg in the morning and 30 mg in the evening
Day 6 and onward: 30 mg twice daily
Otezla and Humira are not the same. Otezla is an oral medication that can treat psoriatic arthritis, plaque psoriasis, and oral ulcers associated with Behçet’s Disease.
Humira is an injectable medicine. Like Otezla, it can treat psoriatic arthritis and plaque psoriasis but not oral ulcers associated with Behçet’s Disease. Humira also can treat many other conditions, such as rheumatoid arthritis, Crohn’s disease, uveitis, and others.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved