What is Rybelsus: Uses, Warnings & Interactions

Take your medicine as directed. The dose may need to be changed during treatment.

Please read the Medication Guide that comes with Rybelsus.

Take one dose orally daily.

Take the tablet on an empty stomach right after waking up.

Swallow the tablet whole with a small amount of water (less than four ounces). Do not crush, break, or chew it.

Do not eat, drink, or take other oral medications for at least 30 minutes after a dose.

Store Rybelsus tablets at room temperature in a dry place protected from moisture. Keep the container closed unless taking a dose.

Skip a missed dose.

Take the next dose the following day first thing in the morning.

This medicine is not right for everyone. 

Do not use it if you have had an allergic reaction to semaglutide or if you have: 

• A family history of medullary thyroid cancer (MTC)

• Multiple endocrine neoplasia syndrome type 2 (MEN 2)

Rybelsus should never be used in people with Type 1 diabetes.

The prescribing doctor will need regular office visits and blood tests to monitor the effectiveness and safety of Rybelsus therapy. Keep all appointments.

Tell any doctor or other healthcare provider who treats you that you are using Rybelsus. 

Before starting Rybelsus, tell the prescriber if you are pregnant, breastfeeding, or have:

• Kidney disease

• Pancreas problems

• Eye problems due to diabetes

• Bariatric surgery

Rybelsus can cause serious problems, including:

• Increased risk of medullary thyroid cancer

• Swelling of the pancreas

• Worsening of kidney disease

• Worsening of diabetic retinopathy

• Low blood sugar (in people who are also taking drugs that increase insulin production) 

Take all doses on an empty stomach, and don’t eat or drink for at least 30 minutes after taking a dose. Rybelsus has decreased effectiveness if these rules aren’t followed.

Rybelsus has no major drug interactions but can cause mild to moderate problems with many types of drugs.

Rybelsus can make other oral medications less effective, so tell the prescriber and pharmacist about all prescription drugs, over-the-counter medications, and supplements you take before starting Rybelsus.

Rybelsus can cause low blood sugar in people taking antidiabetic medications called insulin secretagogues (meglitinides and sulfonylureas). Here are complete lists of meglitinides and sulfonylureas.