What is Triamterene? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Triamterene overview

BRAND NAMES:

  • Dyrenium

Generic Names:

  • Triamterene

Uses:

  • Treats fluid retention (edema) and high blood pressure. This medicine is a diuretic (water pill).

Therapeutic Classes:

  • Cardiovascular Agent

Forms:

  • Capsule, Tablet

How it’s taken:

  • By mouth

What is Triamterene used for?

What form(s) does Triamterene come in?

  • Capsule

  • Tablet

What are common Triamterene dosages?

  • Capsule 50MG

  • Capsule 100MG

  • Bottle 1GM of

Triamterene images - What does Triamterene look like?

  • Triamterene
    100mg capsule

  • Triamterene
    50mg capsule

How to take Triamterene

  • Your doctor will tell you how much of this medicine to take and how often. Do not take more medicine or take it more often than your doctor tells you to.

  • It is best to take this medicine after meals. Carefully follow your doctor's instructions about any special diet.

  • Your doctor will tell you how much of this medicine to take and how often. Do not take more medicine or take it more often than your doctor tells you to.

  • It is best to take this medicine after meals. Carefully follow your doctor's instructions about any special diet.

What to do if you miss a dose of Triamterene

  • If you miss a dose or forget to take your medicine, take it as soon as you can. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose.

  • Do not use extra medicine to make up for a missed dose.

Triamterene contraindications - Who shouldn't take Triamterene?

  • You should not use this medicine if you have had an allergic reaction to triamterene or sulfa drugs, or if you have liver disease, kidney disease, high potassium levels in your blood (hyperkalemia), or are unable to urinate. You should not use this medicine if you are using potassium supplements, salt substitutes, or other diuretics such as spironolactone (Aldactazide®, Aldactone®) or amiloride (Midamor®, Moduretic®).

Triamterene warnings

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have diabetes, lupus, gout, pancreatitis, or kidney stones.

  • This medicine may make you dizzy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

  • This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.

  • Make sure any doctor or dentist who treats you knows that you are using this medicine.

  • Skin rash or itching

  • Unusual bleeding or bruising

Triamterene interactions & what to avoid when taking Triamterene

  • Make sure your doctor knows if you are also using cyclosporine (Neoral®, Sandimmune®), dofetilide (Tikosyn„¢), lithium, potassium supplements, salt substitutes, pain or arthritis medicine (such as aspirin, Advil®, Aleve®, Indocin®, Motrin®, Orudis®, Relafen®), or other blood pressure (such as Accupril®, Altace®, Capoten®, Lotensin®, Lotrel®, Monopril®, Prinivil®, Univasc®, Vasotec®, Zestril®).

  • Do not drink alcohol while you are using this medicine.

  • This medicine may make your skin more sensitive to sunlight. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.

  • Make sure any doctor or dentist who treats you knows that you are using this medicine.

Triamterene side effects - How does Triamterene make you feel?

Serious Side Effects

  • Confusion, weakness, irregular heartbeat, shortness of breath, numbness or tingling in hands, feet, or lips

  • Dry mouth, increased thirst, muscle cramps, nausea or vomiting

  • Fever, chills, cough, hoarseness

  • Unusual bleeding or bruising

  • Problems urinating, pain in side or lower back

  • Skin rash or itching

Less Serious Side Effects

  • Mild nausea, vomiting, diarrhea, or stomach upset

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