What is Ascomp-Codeine: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Ascomp-Codeine overview

BRAND NAMES:

  • Fiorinal w/Codeine, Ascomp w/Codeine, Fiorinal w/Codeine

Generic Names:

  • Butalbital-Asa-Caff-Codeine

Uses:

  • Treats tension headaches. This medicine contains an NSAID and a narcotic pain reliever.

Therapeutic Classes:

  • Opioid/Barbiturate Combination

Forms:

  • Capsule

How it’s taken:

  • By mouth

What is Ascomp-Codeine used for?

What form(s) does Ascomp-Codeine come in

  • Capsule

What are common Ascomp-Codeine doses?

  • Capsule 50-325-40-30MG

Common Ascomp-Codeine prescriptions

  • Ascomp-Codeine
    50-325-40-30mg capsule

How to take Ascomp-Codeine

  • Your doctor will tell you how much medicine to use. Do not use more than directed. An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.

  • This medicine is not for long-term use.

  • This medicine works best if you take it at the first sign of headache or pain.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in a safe and secure place. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA we bsite for locations. Here is the link to the FDA safe disposal of medicines web site: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Your doctor will tell you how much medicine to use. Do not use more than directed. An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.

  • This medicine works best if you take it at the first sign of headache or pain.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in a safe and secure place. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA we bsite for locations. Here is the link to the FDA safe disposal of medicines web site: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

  • This medicine is not for long-term use.

What to do if you miss a dose of Ascomp-Codeine

Ascomp-Codeine contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to butalbital, caffeine, codeine, aspirin, or other NSAID medicine, or if you have porphyria, bleeding or blood clotting problems (such as hemophilia, thrombocytopenia, vitamin K deficiency), Reye's syndrome, stomach blockage or ulcers, severe breathing problems, or a history of asthma with nasal polyps and rhinitis.

Ascomp-Codeine warnings

  • Tell your doctor if you are pregnant, or if you have kidney disease, liver disease, Addison disease, breathing problems (such as asthma, COPD, sleep apnea), gallbladder problems, pancreas problems, an enlarged prostate, trouble urinating, an underactive thyroid, or stomach problems. Tell your doctor if you have a history of depression, head injury, seizures, or addiction to drugs or alcohol.

  • Do not breastfeed while you are using this medicine, unless you have your doctor's permission to do so.

  • This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Serotonin syndrome (when used with certain medicines)

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Seizure

  • Trouble breathing, shallow breathing

  • Unusual bleeding, bruising, or weakness

Ascomp-Codeine interactions

  • Do not use this medicine if you are using or have used an MAO inhibitor within the past 14 days.

  • Some medicines can affect how this medicine works. Tell your doctor if you are using any of the following: 6-mercaptopurine, acetazolamide, amiodarone, amphotericin B, bacitracin, carbamazepine, cisplatin, cyclosporine, erythromycin, foscarnet, ketoconazole, methazolamide, methotrexate, mirtazapine, phenytoin, probenecid, quinidine, rifampin, ritonavir, sulfinpyrazone, tramadol, trazodone, valproic acid, vancomycin injectionAminoglycoside antibioticAnother NSAID pain or arthritis medicine (including diclofenac, ibuprofen, ketorolac, naproxen)Blood pressure medicine (including captopril, metoprolol, propranolol, ramipril)Blood thinner medicine (including apixaban, clopidogrel, enoxaparin, heparin, prasugrel, rivaroxaban, warfarin)Diuretic (water pill)Insulin or oral diabetes medicineMedicine to treat anxiety, depression, or mental health problemsPhenothiazine medicineSteroid medicine (including hydrocortisone, methylprednisolone, prednisolone, prednisone)

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are using buprenorphine, butorphanol, nalbuphine, pentazocine, or a muscle relaxer.

  • Do not drink alcohol while you are using this medicine.

  • Do not give this medicine to a child. Serious breathing problems and deaths have occurred when children have been given medicine that contains codeine.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Ascomp-Codeine side effects

Serious Side Effects

  • Fast or pounding heartbeat

  • Unusual bleeding, bruising, or weakness

  • Blistering, peeling, red skin rash

  • Unusual bleeding, bruising, or weakness

  • Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures

  • Severe constipation or stomach pain

  • Trouble breathing, shallow breathing

  • Bloody or black, tarry stools

  • Change in how much or how often you urinate, painful urination

  • Lightheadedness, dizziness, fainting

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Anxiety, restlessness, fever, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there

Less Serious Side Effects

  • Constipation or stomach pain

  • Mild drowsiness

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