What is BeneFIX? Uses, warnings & side effects

Updated May 14, 2025  •  Published Jun 30, 2021

BeneFIX overview

BRAND NAMES:

  • BeneFIX, Ixinity, Rixubis

Generic Names:

  • Benefix

Uses:

  • Prevents and controls bleeding in patients with hemophilia B.

Therapeutic Classes:

  • Antihemophilic Agent, Hemostatic

Forms:

  • Injectable

How it’s taken:

  • By injection

What is BeneFIX used for?

Benefix is an injectable medication used to treat or prevent bleeding in patients with hemophilia B. It is a protein made by man similar to the one naturally produced in the body which assists in clotting the blood. Benefix is not for patients with hemophilia A factor VIII deficiency.

What form(s) does BeneFIX come in?

  • Injectable

What are common BeneFIX dosages?

  • Kit 2000UNIT

BeneFIX images - What does BeneFIX look like?

  • BeneFIX
    1 kit box

  • BeneFIX
    2000unit kit

  • BeneFIX
    250unit kit

  • BeneFIX
    3000unit kit

  • BeneFIX
    500unit kit

How to take BeneFIX

  • Injection route: Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection route: A nurse or other health provider will give you this medicine.

  • Injection route: You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

  • Injection route: Use a new needle and syringe each time you inject your medicine.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Ask your doctor or pharmacist for instructions, if you need to use this medicine on a schedule.

  • Each brand of medicine has different instructions for how to store it. Follow the directions for your brand. Ask your doctor or pharmacist if you have any questions. Do not use this medicine after the expiration date.

  • Injection route: Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

What to do if you miss a dose of BeneFIX

BeneFIX contraindications - Who shouldn't take BeneFIX?

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to coagulation factor (recombinant) or hamster proteins, or if you have disseminated intravascular coagulation (DIC).

BeneFIX warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease or liver disease.

  • This medicine may cause the following problems:Increased risk for blood clotsKidney problems

  • Tell your doctor if this medicine does not prevent or stop bleeding as expected.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Pain in your lower leg (calf)

  • Sudden or severe headache, problems with vision, speech, or walking

  • Unexplained bleeding

BeneFIX interactions & what to avoid when taking BeneFIX

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease or liver disease.

  • This medicine may cause the following problems:Increased risk for blood clotsKidney problems

  • Tell your doctor if this medicine does not prevent or stop bleeding as expected.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

BeneFIX side effects - How does BeneFIX make you feel?

Serious Side Effects

  • Numbness or weakness in your arm or leg, or on one side of your body

  • Pain in your lower leg (calf)

  • Chest pain, trouble breathing, coughing up blood

  • Sudden or severe headache, problems with vision, speech, or walking

  • Lightheadedness, dizziness, fainting

  • Unexplained bleeding

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Change in how much or how often you urinate

Less Serious Side Effects

  • Headache

  • Pain, itching, burning, redness, swelling, or a lump under your skin where the needle is placed

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