What is Blephamide: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Blephamide overview

BRAND NAMES:

  • Vasocidin, TobraDex ST, Blephamide S.O.P., Maxitrol, Blephamide, Neo-Polycin HC, Pred-G, TobraDex ST, Tobradex, Zylet, Zylet, Pred-G S.O.P., Pred-G, Tobradex, Pred-G S.O.P., Blephamide, Blephamide S.O.P., Blephamide S.O.P., Metimyd, Vasocidin

Generic Names:

  • Blephamide

Uses:

  • Treats infections of the eye and eye irritation, swelling, and redness., Treats and prevents eye infection and inflammation. This medicine is a combination of a sulfa drug and a corticosteroid.

Therapeutic Classes:

  • Aminoglycoside/Corticosteroid Combination, Tetracycline/Corticosteroid Combination, Sulfonamide/Corticosteroid Combination, Chloramphenicol/Corticosteroid Combination, Sulfonamide/Corticosteroid Combination

Forms:

  • Ointment, Drop, Liquid, Liquid, Ointment, Drop

How it’s taken:

  • Into the eye, Into the eye

What is Blephamide used for?

What form(s) does Blephamide come in

  • Ointment

  • Drop

  • Liquid

  • Liquid

  • Ointment

  • Drop

What are common Blephamide doses?

  • Bottle 5ML of 10-0.2%

  • Bottle 10ML of 10-0.2%

Common Blephamide prescriptions

  • Blephamide
    10ml of 10-0.2% bottle

  • Blephamide
    5ml of 10-0.2% bottle

How to take Blephamide

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Ophthalmic routeWash your hands with soap and water before and after using this medicine.

  • Eye drops: Do not use this medicine if the liquid has become darker in color.Do not wear contact lenses while you are using this medicine.Ophthalmic routeShake the eye drops well just before each use. Ophthalmic routeLie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket. Ophthalmic routeTo use the eye drops: Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away. Keep the bottle upright when you are not using it.

  • Eye ointment: Ophthalmic routeTo use the ointment: Hold the tip of the tube close to your eye with the other hand. Avoid touching the tip of the tube to your eye or finger. Squeeze a ribbon of ointment into the pocket between your lower lid and eyeball. Close your eyes for 1 to 2 minutes. Wipe the tip with a clean tissue and close the tube tightly. Keep the tube tightly closed when you are not using it.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store this medicine in a cool, dry place or at room temperature away from heat and direct light. Do not freeze.

  • To use the eye drops: Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away. Keep the bottle upright when you are not using it.

  • To use the ointment: Hold the tip of the tube close to your eye with the other hand. Avoid touching the tip of the tube to your eye or finger. Squeeze a ribbon of ointment into the pocket between your lower lid and eyeball. Close your eyes for 1 to 2 minutes. Wipe the tip with a clean tissue and close the tube tightly. Keep the tube tightly closed when you are not using it.

  • To use the ointment: Hold the tip of the tube close to your eye with the other hand. Avoid touching the tip of the tube to your eye or finger. Squeeze a ribbon of ointment into the pocket between your lower lid and eyeball. Close your eyes for 1 to 2 minutes. Wipe the tip with a clean tissue and close the tube tightly. Keep the tube tightly closed when you are not using it.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Ophthalmic routeWash your hands with soap and water before and after using this medicine.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Eye drops: Do not use this medicine if the liquid has become darker in color.Do not wear contact lenses while you are using this medicine.Ophthalmic routeShake the eye drops well just before each use. Ophthalmic routeLie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket. Ophthalmic routeTo use the eye drops: Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away. Keep the bottle upright when you are not using it.

  • Store this medicine in a cool, dry place or at room temperature away from heat and direct light. Do not freeze.

  • To use the eye drops: Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away. Keep the bottle upright when you are not using it.

  • Eye ointment: Ophthalmic routeTo use the ointment: Hold the tip of the tube close to your eye with the other hand. Avoid touching the tip of the tube to your eye or finger. Squeeze a ribbon of ointment into the pocket between your lower lid and eyeball. Close your eyes for 1 to 2 minutes. Wipe the tip with a clean tissue and close the tube tightly. Keep the tube tightly closed when you are not using it.

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to. This medicine is not for long-term use.

  • Wash your hands before and after using the medicine.

  • Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket.

  • Shake the eye drops well just before each use.

  • To use the eye drops: Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away. Keep the bottle upright when you are not using it.

  • To use the ointment: Hold the tip of the tube close to your eye with the other hand. Avoid touching the tip of the tube to your eye or finger. Squeeze a ribbon of ointment into the pocket between your lower lid and eyeball. Close your eyes for 1 to 2 minutes. Wipe the tip with a clean tissue and close the tube tightly. Keep the tube tightly closed when you are not using it.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket.

  • To use the eye drops: Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away. Keep the bottle upright when you are not using it.

  • Wash your hands before and after using the medicine.

  • Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to. This medicine is not for long-term use.

  • To use the ointment: Hold the tip of the tube close to your eye with the other hand. Avoid touching the tip of the tube to your eye or finger. Squeeze a ribbon of ointment into the pocket between your lower lid and eyeball. Close your eyes for 1 to 2 minutes. Wipe the tip with a clean tissue and close the tube tightly. Keep the tube tightly closed when you are not using it.

  • Shake the eye drops well just before each use.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

What to do if you miss a dose of Blephamide

  • Do not use extra medicine to make up for a missed dose.

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose.

  • If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose.

  • Do not use extra medicine to make up for a missed dose.

Blephamide contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to sulfacetamide, prednisolone, or other sulfa drugs or corticosteroids, or if you have certain other eye infections (including herpes simplex).

  • You should not use this medicine if you are allergic to any antibacterial medicines or to steroids, such as cortisone, hydrocortisone, or prednisone.

Blephamide warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have glaucoma, cataracts, or other eye problems (including severe dry eyes).

  • This medicine may cause the following problems:Eye problems (including glaucoma, cataracts, infections) with long-term useIncreased pressure inside the eyesSlow wound healing after eye surgerySerious skin reactions

  • You will need to have your eyes checked regularly if you use the medicine for 10 days or longer. Be sure to keep all appointments.

  • If your condition has not improved within 2 days, stop using the medicine and call your doctor.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Ophthalmic routeIf you hurt your eye, develop an eye infection, or need to have eye surgery, talk with your doctor right away. You may need to change your medicine or stop using it.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Make sure your doctor knows if you have glaucoma, cataracts, or any other eye condition before taking this medicine.

  • If you are pregnant or breastfeeding, talk to your doctor before using this medicine.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

Blephamide interactions

  • Call your doctor if your symptoms do not improve or if they get worse.

  • Make sure your doctor knows if you have glaucoma, cataracts, or any other eye condition before taking this medicine.

  • If you are pregnant or breastfeeding, talk to your doctor before using this medicine.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Some medicines can affect how sulfacetamide/prednisolone works. Tell your doctor if you are also using silver preparations, including silver nitrate or silver sulfadiazine.

  • If your condition has not improved within 2 days, stop using the medicine and call your doctor.

  • This medicine could increase the pressure inside your eye or cause other eye problems, including cataracts. Keep all appointments so your doctor can check for these problems.

  • Do not stop using this medicine suddenly without asking your doctor. You may need to use less and less before stopping it completely.

Blephamide side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Severe eye irritation that was not there before using this medicine

  • Vision changes

  • Yellow eyes or skin

  • Sensitivity to light, trouble seeing, or other changes in vision

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

  • Yellow eyes or skin

  • Unusual tiredness or weakness

  • Redness, pain, swelling, or discharge not present in your eye before using this medicine

Less Serious Side Effects

  • Stinging when putting the medicine in your eyes

  • Dry eyes, drooping eyelids

  • Stinging, redness, or burning of the eye

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