What is Blisovi Fe: Uses, Warnings & Interactions

Please read the Patient Information sheet before starting this medicine.

Follow the instructions in the Patient Information sheet.

Take Blisovi Fe pills at the same time every day. 

Take all the pills in their numbered order.

• Blisovi Fe 1/20 has 21 yellow tablets containing active ingredients and seven inert brown tablets with iron. 

• Blisovi Fe 1.5/30 has 21 pink tablets containing active ingredients and seven inert brown tablets with iron. 

• Take the first tablet (number 1) either on the day your period starts or the first Sunday after your period starts.

• Tablets can be taken without regard to food. 

• Swallow the tablet whole with a drink of water. Do not crush, break, or chew it.

• When the last brown pill is taken, start the next pack with the first yellow/pink pill.

• The first pill in the blister pack should always be taken on the same day of the week each cycle.

Ask the prescriber for special instructions about taking Blisovi Fe if:

• You’re switching from another birth control pill or contraceptive method

• You have had an abortion or miscarriage

• You have given birth

If you vomit or have diarrhea for any reason, use backup birth control and contact the prescriber.

Store Blisovi Fe away from light at room temperature. 

Forgetting doses increases the risk of pregnancy. 

• In addition to taking missed doses, you may sometimes need to use backup birth control whenever you have sex for seven days.

If a yellow/pink pill is missed:

• Take the missed dose as soon as possible. 

• Take the next tablet at its regular time.

• If necessary, two doses can be taken on the same day to make up for a missed dose. 

• Pregnancy is not a risk if just one pill is missed. Backup birth control is not needed.

If you miss two yellow/pink pills in a row:

• Take two tablets as soon as possible.

• Take two tablets the next day.

• Use backup birth control for the next seven days.

If you miss two yellow/pink pills in a row in the third week: 

• Start over with a new Blisovi Fe pack. 

• Day 1 starters should start the new pack immediately.

• Sunday starters should continue taking pills from the old pack and start the new pack on Sunday.

• Use backup birth control until you’ve taken seven yellow/pink pills.

If you miss three or more yellow pills in a row in any week:

• You will have to start a new pack. 

• Day 1 starters will start the new pack immediately.

• Sunday starters will continue taking pills from the old pack and start the new pack on Sunday.

• Use backup birth control until you’ve taken seven yellow/pink pills.

If you miss any of the seven brown pills: 

• Throw away the unused brown pills

• Take all the remaining pills as scheduled. 

• Start the next pack as scheduled. 

• You do not need backup birth control.

If you’re not sure about a missed pill, use backup birth control.  

This medicine is not right for everyone. 

Do not use it if you are pregnant, older than 35 and smoke, or have:

• Current or past blood clot problems, including deep vein thrombosis, heart attack, or stroke

• Coronary artery disease

• Certain types of heart valve or heart rhythm problems

• Uncontrolled high blood pressure

• Blood vessel damage due to diabetes

• Abnormal uterine bleeding that has not been checked by a doctor

• Liver cancer

• A history of jaundice while pregnant or on birth control pills

• A history of hormone-sensitive breast cancer

• Endometrial or other estrogen-receptive cancers

• Certain types of headaches (focal headaches) or migraine headaches with aura

Tell any doctor or other healthcare provider who treats you that you are using hormonal birth control. 

• Birth control pills can affect several important lab tests. 

• Blisovi Fe doses may need to stop a few weeks before and after surgical procedures.

The use of hormonal birth control requires regular visits and tests. Keep all appointments.

Immediately tell the doctor if you become pregnant, think you’re pregnant, or if you miss two periods in a row.

• If you miss one period, tell the doctor about it if you have missed doses during that month.

Before starting any birth control pill, make sure the prescriber knows if you smoke, are breastfeeding, or have: 

• Heart or blood vessel disease

• High blood pressure

• Diabetes

• High cholesterol

• Migraines

• A history of depression

• A congenital condition that causes facial and skin swelling (hereditary angioedema)

• Yellowing of the eyes or skin during pregnancy or while taking birth control pills

• Given birth in the last four weeks

Blisovi Fe can cause serious problems, including:

• Increased risk of blood clots

• Increased risk of breast or other hormone-sensitive cancers

• Liver problems

• Gallbladder problems

• High blood pressure

• High cholesterol and fats

Birth control pills can cause some light bleeding or spotting between periods. 

• This is usually normal in the first couple of months. 

• Call the prescriber if the bleeding is heavy or lasts longer than seven days.

Birth control pills can cause periods with light bleeding or no bleeding. This is not normally a cause for concern, but talk to a doctor if it:

• Is accompanied by pregnancy symptoms (like morning sickness) 

• Happens in a month where doses were missed

• Happens two months in a row

This medicine may cause patches of dark skin. 

• Use sunscreen or protective clothing when exposed to the sun 

• Avoid tanning booths or sunlamps

Birth control pills do not protect against HIV/AIDS infection or other sexually transmitted diseases. 

Birth control pills may decrease lactation in women who are breastfeeding.

Some women may experience temporary infertility after quitting an oral contraceptive.

Blisovi Fe can never be taken with any hepatitis C drug that contains ombitasvir/paritaprevir/ritonavir.

Before starting Blisovi Fe, tell the prescribing healthcare provider about all prescription drugs, over-the-counter medicines, and supplements being taken, particularly:

• Drugs that treat bacterial infections

• Drugs that treat fungal infections

• Drugs that treat seizures

• Barbiturates

• Thyroid hormones

• Acetaminophen, aprepitant, ascorbic acid, atorvastatin, bosentan, clofibric acid, cyclosporine, morphine, phenylbutazone, prednisolone, rosuvastatin, salicylic acid, temazepam, theophylline, troglitazone

Avoid grapefruit or grapefruit juice when taking Blisovi Fe.

Tell other healthcare providers about hormonal birth control use before they prescribe new medications.