What is Buprenorphine Hcl: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Buprenorphine Hcl overview

BRAND NAMES:

  • Butrans, Butrans

Generic Names:

  • Buprenorphine

Uses:

  • Treats severe pain. This medicine is a narcotic pain reliever.

Therapeutic Classes:

  • Analgesic

Forms:

  • Patch

How it’s taken:

  • Absorbed through the skin

What is Buprenorphine Hcl used for?

Buprenorphine comes in the form of an injectable solution and is used to help relieve severe ongoing pain in cases such as arthritis and chronic back pain. It works in the brain to change how the body feels and responds to pain. Common side effects may include itching, headache, depressed mood, nausea and vomiting.

What form(s) does Buprenorphine Hcl come in

  • Patch

What are common Buprenorphine Hcl doses?

  • Box 4 Patch Weekly

Common Buprenorphine Hcl prescriptions

  • Buprenorphine
    10mcg/hr, 4 patches carton

  • Buprenorphine
    15mcg/hr, 4 patches carton

  • Buprenorphine
    20mcg/hr, 4 patches carton

  • Buprenorphine
    4 patches of 10mcg/hr carton

  • Buprenorphine
    4 patches of 15mcg/hr carton

  • Buprenorphine
    4 patches of 20mcg/hr carton

  • Buprenorphine
    4 patches of 5mcg/hr carton

  • Buprenorphine
    4 patches of 7.5mcg/hr carton

  • Buprenorphine
    5mcg/hr, 4 patches carton

  • Buprenorphine
    7.5mcg/hr, 4 patches carton

  • Buprenorphine
    10mcg/hr patch pouch

  • Buprenorphine
    15mcg/hr patch pouch

  • Buprenorphine
    20mcg/hr patch pouch

  • Buprenorphine
    5mcg/hr patch pouch

  • Buprenorphine
    7.5mcg/hr patch pouch

How to take Buprenorphine Hcl

  • Transdermal routeYour doctor will tell you how many patches to use, where to apply them, and how often to apply them. Do not use more patches or apply them more often than your doctor tells you to. An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.

  • Transdermal routeWash your hands with soap and water before and after applying a patch.

  • Do not use soap, lotion, alcohol, or oil on your skin before you apply the patch. Wash your skin only with water and let it dry completely. Do not shave the skin where you will apply the patch. You may cut the hair with a pair of scissors.

  • Transdermal routeLeave the patch in its sealed wrapper until you are ready to put it on. Tear the wrapper open carefully. NEVER CUT the wrapper or the patch with scissors. Do not use any patch that has been cut by accident. Do not use this medicine if the pouch seal is broken or if the patch is damaged in any way. If any medicine leaks out of the patch and gets directly on your skin, wash it off right away with water.

  • Transdermal routeThe patient instructions will show the body areas where you can wear the patch. When putting on each new patch, choose a different place within these areas. Do not put the new patch on the same place you wore the last one. Be sure to remove the old patch before applying a new one. After you apply the patch, push down on it with the palm of your hand for 15 seconds to make sure it sticks to your skin.

  • Transdermal routeDo not put the patch over burns, cuts, or irritated skin.

  • Transdermal routePut on a new patch if the old one has fallen off and cannot be reapplied. If a patch is loose, tape it to your skin with first aid tape.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Transdermal routeIf you forget to wear or change a patch, put one on as soon as you can. If it is almost time to put on your next patch, wait until then to apply a new patch and skip the one you missed. Do not apply extra patches to make up for a missed dose.

  • Store the patches at room temperature in the original package, away from heat, moisture, and direct light.

  • Disposal: Follow the instructions you receive with the patch disposal unit. You will need to seal each patch in a disposal unit, even if it is a patch you did not use. Make sure children and pets cannot come in contact with used or leftover patches. Wash your hands thoroughly with soap and water after you handle the patch. If you must dispose of a patch without the patch disposal unit, be sure you fold it in half with the sticky sides together so no one comes in contact with the medicine.Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website:www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

  • Missed dose: Transdermal routeIf you forget to wear or change a patch, put one on as soon as you can. If it is almost time to put on your next patch, wait until then to apply a new patch and skip the one you missed. Do not apply extra patches to make up for a missed dose.

  • Transdermal routeLeave the patch in its sealed wrapper until you are ready to put it on. Tear the wrapper open carefully. NEVER CUT the wrapper or the patch with scissors. Do not use any patch that has been cut by accident. Do not use this medicine if the pouch seal is broken or if the patch is damaged in any way. If any medicine leaks out of the patch and gets directly on your skin, wash it off right away with water.

  • Transdermal routeDo not put the patch over burns, cuts, or irritated skin.

  • Transdermal routeWash your hands with soap and water before and after applying a patch.

  • Transdermal routeThe patient instructions will show the body areas where you can wear the patch. When putting on each new patch, choose a different place within these areas. Do not put the new patch on the same place you wore the last one. Be sure to remove the old patch before applying a new one. After you apply the patch, push down on it with the palm of your hand for 15 seconds to make sure it sticks to your skin.

  • Disposal: Follow the instructions you receive with the patch disposal unit. You will need to seal each patch in a disposal unit, even if it is a patch you did not use. Make sure children and pets cannot come in contact with used or leftover patches. Wash your hands thoroughly with soap and water after you handle the patch. If you must dispose of a patch without the patch disposal unit, be sure you fold it in half with the sticky sides together so no one comes in contact with the medicine.Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website:www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

  • Transdermal routeYour doctor will tell you how many patches to use, where to apply them, and how often to apply them. Do not use more patches or apply them more often than your doctor tells you to. An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Transdermal routePut on a new patch if the old one has fallen off and cannot be reapplied. If a patch is loose, tape it to your skin with first aid tape.

  • Store the patches at room temperature in the original package, away from heat, moisture, and direct light.

  • Do not use soap, lotion, alcohol, or oil on your skin before you apply the patch. Wash your skin only with water and let it dry completely. Do not shave the skin where you will apply the patch. You may cut the hair with a pair of scissors.

What to do if you miss a dose of Buprenorphine Hcl

Buprenorphine Hcl contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to buprenorphine or adhesives, or if you have severe breathing or lung problems or stomach blockage (including paralytic ileus).

Buprenorphine Hcl warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lung disease or breathing problems (such as COPD, sleep apnea), heart disease, heart rhythm problems, adrenal problems, gallbladder problems, low blood pressure, pancreas problems, or stomach or bowel problems. Tell your doctor if you have a history of head injury, brain tumor, seizures, depression, or alcohol or drug abuse.

  • This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Heart rhythm problems, including QT prolongationLiver problemsSerotonin syndrome, when used with certain medicines

  • Do not let the patch get too hot. Avoid direct sunlight, and do not use a heating pad, electric blanket, heated waterbed, sauna, sun lamp, or hot tub. Call your doctor if you have a fever higher than 102 degrees F.

  • Be careful about letting other people come in contact with your patch. If any medicine gets on another person, wash it off right away with water.

  • This medicine may make you lightheaded, dizzy, or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Buprenorphine Hcl interactions

  • Do not drink alcohol while you are using this medicine.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are also using butorphanol, nalbuphine, pentazocine, a benzodiazepine, or a muscle relaxer.

  • Some medicines can affect how buprenorphine works. Tell your doctor if you are using any of the following: Carbamazepine, cyclobenzaprine, erythromycin, ketoconazole, metaxalone, mirtazapine, phenytoin, rifampin, ritonavir, tramadol, trazodoneDiuretic (water pill)Medicine to treat anxiety or mental health illnessMedicine to treat depression, including MAO inhibitor in the past 14 daysMedicine to treat heart rhythm problem (including amiodarone, disopyramide, dofetilide, procainamide, quinidine, sotalol)Phenothiazine medicineTriptan or medicine to treat migraine headaches

  • Be careful about letting other people come in contact with your patch. If any medicine gets on another person, wash it off right away with water.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • This medicine may make you lightheaded, dizzy, or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Buprenorphine Hcl side effects

Serious Side Effects

  • Trouble breathing or slow breathing

  • Severe confusion, lightheadedness, dizziness, fainting

  • Fast, slow, or uneven heartbeat

  • Swelling, burns, or blisters where the patch is placed

  • Severe constipation, stomach pain, or vomiting

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there

  • Blue lips, fingernails, or skin

  • Extreme dizziness or weakness, shallow breathing, sweating, seizures, cold or clammy skin

  • Yellow skin or eyes

Less Serious Side Effects

  • Redness, itching, or mild skin rash where the patch is placed

  • Mild sleepiness or tiredness

  • Mild constipation, nausea, or vomiting

  • Headache

Subscribe to our savings newsletter

Health education, drug info, wellness & more

By clicking 'Subscribe', I agree to SingleCare's Terms & Conditions.