What is Centrum Silver: Uses, Warnings & Interactions
Updated May 14,
2025 • Published Dec 30,
2020
Centrum Silver is a brand-name multivitamin and multimineral supplement that is safe enough to purchase without a prescription. Widely available in stores, Centrum Silver is formulated for adults older than 50. As with all multivitamins, its safe use depends on taking it as directed. For Centrum Silver, that means taking only one tablet per day.
Centrum Silver, Centrum Men 50+, Centrum Women 50+, Centrum Minis Men 50+, Centrum Minis Women 50+, Centrum Multigummies Adults 50+, Centrum Multigummies Men 50+, Centrum Multigummies Women 50+
Generic Names:
Multivitamin/multimineral
Uses:
Centrum Silver is intended to provide daily vitamins and minerals to help maintain heart health, eye health, general health, and brain function.
Daily Centrum Silver is used to prevent or treat vitamin or mineral deficiencies due to diet or medical conditions. It is directed at adults older than 50 to help maintain their general health.
What form(s) does Centrum Silver come in
Tablet
One dosage strength containing multiple micronutrients
What are common Centrum Silver doses?
For adults: 1 tablet per day taken with food
Common Centrum Silver prescriptions
Centrum Silver 110 tablets bottle
Centrum Silver 125 tablets bottle
Centrum Silver 150 tablets bottle
Centrum Silver 220 tablets bottle
Centrum Silver 30 tablets bottle
Centrum Silver 60 tablets bottle
Centrum Silver 60 tablets chewable bottle
Centrum Silver 80 tablets bottle
How to take Centrum Silver
Follow the instructions on the package label if you are using this medicine without a prescription
Take only one tablet per day
Tablets should be taken with food
Swallow the tablet whole
What to do if you miss a dose of Centrum Silver
You should take one tablet per day.
If you forget to take a tablet, it can be taken at any time on the same day.
If it’s the next day, it’s probably best to skip the missed tablet and take the next day’s tablet.
It is generally not harmful if you miss a dose of a store-bought vitamin supplement. Check with your doctor or pharmacist if you have any questions.
Centrum Silver contraindications
You should not use this medicine if you have had an allergic reaction to any of the ingredients. If you are not sure what the ingredients are, ask your doctor or pharmacist.
Centrum Silver warnings
Tell any doctor or other healthcare provider who treats you that you are using this medicine.
You may need to stop using this medicine several days before you have surgery or medical tests.
As a general rule, you should talk to your doctor before taking multivitamins, multiminerals, or similar supplements, especially if you:
Are pregnant
Have a medical condition
Are taking prescription medications
Are taking other supplements
People with kidney disease or who are on dialysis should avoid taking multivitamins because some of the vitamins in the tablets can cause problems. Ask the doctor what vitamin and mineral supplements are safe to take.
Centrum Silver is not formulated for children. The fat-soluble vitamin and mineral doses in each tablet may not be safe for children, particularly the iron dose. One of the leading causes of fatal poisonings in very young children involves supplements containing iron, so keep these tablets out of their reach.
Do not take more than one tablet per day unless directed to by a doctor.
Multivitamins can turn urine bright yellow and stools a darker color. This is normal.
Centrum Silver interactions
To avoid possible drug interactions, tell healthcare providers you are taking Centrum Silver.
Many possible drug interactions are possible with multivitamins because of all the ingredients. Most of the drug interactions are minor or insignificant, but that will depend on using the multivitamin as recommended. Drugs to be concerned about include:
Levothyroxine, a drug used to treat underactive thyroid
Drugs that treat osteoporosis called bisphosphonates
The heart rhythm drug digoxin
The Parkinson’s drug levodopa
A doctor can give you medical advice about taking vitamins along with your prescription drugs. In some cases, it may be enough to take Centrum Silver tablets several hours before or after taking one of these drugs. In other cases, you may need to switch to a supplement that does not contain one or more of the ingredients in Centrum Silver.
Centrum Silver side effects
Serious side effects
When taken as directed, Centrum Silver should not cause serious side effects other than possible allergic reactions. Talk to a doctor if you notice any signs or symptoms of an allergic reaction, such as:
Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
When taken in excess, multivitamins like Centrum Silver could cause serious side effects due to vitamin or mineral poisoning. If you are regularly taking excessive doses of Centrum Silver, talk to a doctor if you notice any symptoms of poisoning, such as: