What is Cevimeline: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Cevimeline overview

BRAND NAMES:

  • Evoxac

Generic Names:

  • Cevimeline Hcl

Uses:

  • Treats dry mouth from Sjögren syndrome.

Therapeutic Classes:

  • Central Nervous System Agent

Forms:

  • Capsule

How it’s taken:

  • By mouth

What is Cevimeline used for?

What form(s) does Cevimeline come in

  • Capsule

What are common Cevimeline doses?

  • Capsule 30MG

Common Cevimeline prescriptions

  • Cevimeline HCl
    30mg capsule

How to take Cevimeline

  • Drink plenty of water, especially if you have increased sweating.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Drink plenty of water, especially if you have increased sweating.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

What to do if you miss a dose of Cevimeline

Cevimeline contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to cevimeline, or if you have uncontrolled asthma or an eye disorder, including narrow-angle glaucoma or acute iritis.

Cevimeline warnings

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have heart or blood vessel disease, lung disease or breathing problems (including asthma, bronchitis, COPD), eye problems, or a history of chest pain, heart attack, kidney stones, or gallbladder stones.

  • This medicine may cause the following problems:Heart rhythm problemsBreathing problemsGallbladder problemsKidney problems

  • This medicine may cause blurred or decreased vision, especially at night. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Nausea or vomiting

  • Pain or burning when you urinate

  • Trouble breathing

  • Uncontrollable shaking

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Cevimeline interactions

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • This medicine may make your vision blurry. Be careful when you drive or do anything that requires clear vision.

  • Some medicines can affect how cevimeline works. Tell your doctor if you are using a beta blocker (including atenolol, metoprolol, or propranolol).

  • Tell your doctor if you have kidney or gallbladder stones, heart problems, including heart attack or chest pain (angina), asthma, bronchitis, or chronic obstructive pulmonary disease (COPD).

Cevimeline side effects

Serious Side Effects

  • Severe nausea or vomiting, stomach pain, dark urine, yellow eyes or skin

  • Uncontrollable shaking

  • Uncontrollable shaking

  • Trouble breathing, chest tightness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blurred vision or change in vision, confusion

  • Fainting, lightheadedness, dizziness

  • Fast, slow, or irregular heartbeat

  • Pain or burning feeling when you urinate, bloody or cloudy urine, pain in the lower back or side

Less Serious Side Effects

  • Hot flashes or joint pain

  • Drooling, or more saliva than usual

  • Red, itchy, or watery eyes, runny nose, or a cough

  • Heartburn, indigestion

  • Excessive sweating

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