What is Chemet: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Chemet overview

BRAND NAMES:

  • Chemet, Clovique, Cuprimine, Depen, Ferriprox, Ferriprox Twice-A-Day, Syprine, Jadenu, Chemet

Generic Names:

  • Chemet

Uses:

  • Treats heavy metal poisoning. May also be used to treat rheumatoid arthritis or cystinuria (too much cystine in your urine)., Treats lead poisoning.

Therapeutic Classes:

  • Heavy Metal Chelator, Antirheumatic, Heavy Metal Chelator, Renal-Urologic Agent

Forms:

  • Tablet, Capsule, Capsule

How it’s taken:

  • By mouth, By mouth

What is Chemet used for?

Chemet is a chelating agent that is commonly used to treat patients with severe lead poisoning. It works by attaching itself to the lead in the blood and it passes out with urine.

What form(s) does Chemet come in

  • Tablet

  • Capsule

  • Capsule

What are common Chemet doses?

  • Capsule 100MG

Common Chemet prescriptions

  • Chemet
    100mg capsule

How to take Chemet

  • Drink plenty of water while you are using this medicine. Most people should drink 6 to 8, 8-ounce glasses of water every day. Ask your doctor if that is a proper amount of water for you.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • If you cannot swallow the capsule, you may open it and pour the medicine into a small amount of soft food such as pudding, yogurt, or applesauce. Stir this mixture well and swallow it without chewing. You can also pour the medicine beads into a spoon, swallow the beads, and then drink some fruit drink.

  • Most people will use this medicine for a few weeks. If your symptoms come back after you stop using the medicine, you might need to wait a short time and then use the medicine again for a few weeks.

  • The amount of medicine you take each day might change as your treatment proceeds. Make sure you understand how much medicine to take each day and when to take it.

  • Drink plenty of water while you are using this medicine. Most people should drink 6 to 8, 8-ounce glasses of water every day. Ask your doctor if that is a proper amount of water for you.

  • The amount of medicine you take each day might change as your treatment proceeds. Make sure you understand how much medicine to take each day and when to take it.

  • Most people will use this medicine for a few weeks. If your symptoms come back after you stop using the medicine, you might need to wait a short time and then use the medicine again for a few weeks.

  • If you cannot swallow the capsule, you may open it and pour the medicine into a small amount of soft food such as pudding, yogurt, or applesauce. Stir this mixture well and swallow it without chewing. You can also pour the medicine beads into a spoon, swallow the beads, and then drink some fruit drink.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • You might need to take this medicine on an empty stomach. Take penicillamine or trientine at least 1 hour before eating a meal or 2 hours after eating a meal. Do not eat or drink milk within 1 hour of the time you take this medicine. Ask your doctor or pharmacist if you have questions about what schedule to follow.

  • Oral routeCarefully follow your doctor's instructions about any special diet.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Do not open or chew trientine capsule. If you get any of this medicine on your skin, wash it off right away.

  • If you cannot swallow the succimer capsule, you may open it and pour the medicine into a small amount of soft food such as pudding, yogurt, or applesauce. Stir this mixture well and swallow it without chewing. You can also pour the medicine beads into a spoon, swallow the beads, and then drink some fruit drink.

  • You might need to drink extra water while you are using this medicine.

  • Oral routeCarefully follow your doctor's instructions about any special diet.

  • Do not open or chew trientine capsule. If you get any of this medicine on your skin, wash it off right away.

  • If you cannot swallow the succimer capsule, you may open it and pour the medicine into a small amount of soft food such as pudding, yogurt, or applesauce. Stir this mixture well and swallow it without chewing. You can also pour the medicine beads into a spoon, swallow the beads, and then drink some fruit drink.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • You might need to take this medicine on an empty stomach. Take penicillamine or trientine at least 1 hour before eating a meal or 2 hours after eating a meal. Do not eat or drink milk within 1 hour of the time you take this medicine. Ask your doctor or pharmacist if you have questions about what schedule to follow.

  • You might need to drink extra water while you are using this medicine.

What to do if you miss a dose of Chemet

  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Chemet contraindications

  • You should not use this medicine if you have had an allergic reaction to succimer.

  • Make sure your doctor knows if you have had an allergic reaction to any chelating agent such as penicillamine, succimer, or trientine. Make sure your doctor knows if you are pregnant or breastfeeding. Tell your doctor if you have kidney disease.

Chemet warnings

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Your doctor will also need to check your blood after you stop using the medicine, to make sure the metal is gone from your body.

  • For people who have diabetes: This medicine may affect the results of some urine tests for ketones (such as Ketostix®). Ask your doctor what kind of ketone test you should use while you are using succimer.

  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Tell your doctor if you have ever used succimer before, especially if you had any side effects to it.

  • You must also get rid of the lead or other heavy metal that made you sick. Find out how you have been exposed to a heavy metal. This medicine will not protect you from a heavy metal that you are still being exposed to. Ask your health caregiver about the best ways to get rid of or avoid the heavy metal that caused the problem.

  • Make sure your doctor knows if you are breastfeeding. You probably should not breastfeed while you are being treated with this medicine, because the metal in your body and the medicine will both be in your breast milk.

  • Make sure your doctor knows if you are pregnant, or if you have kidney disease, liver disease, or blood problems.

  • Your skin might be more fragile while you are using penicillamine, especially on your shoulders, elbows, knees, toes, or buttocks. Your skin might also heal more slowly than usual. Talk to your doctor before you have any kind of surgery, because your dose of this medicine might need to be changed.

  • You might need to take your temperature every night when you first start using this medicine.

  • For people who have diabetes: Succimer may affect the results of some urine tests for ketones (such as Ketostix®). Ask your doctor what kind of ketone test you should use while you are using succimer.

  • For Wilson€™s disease, you might need to use this medicine for one to three months before you notice any improvement. The symptoms of Wilson€™s disease might get worse when you first start using this medicine. If your symptoms get very bad or keep getting worse, tell your doctor.

  • Some people have too much heavy metal in their bodies because they were exposed to it, such as in the home or at work. The metal could still be in their surroundings. If this is your situation, then you must get rid of the metal or learn how to protect yourself. This medicine will not protect you from a heavy metal that you are still being exposed to. Find out how you were exposed. Ask your health caregiver about the best ways to get rid of or avoid the heavy metal that caused the problem.

  • Tell your doctor if you have ever used a chelating agent before.

  • Make sure any doctor or dentist who treats you knows that you are using this medicine.

  • Do not stop using this medicine without talking to your doctor first.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, or problems with your blood. Tell your doctor if you are allergic to penicillin.

Chemet interactions

  • You might need to take your temperature every night when you first start using this medicine.

  • Your skin might be more fragile while you are using penicillamine, especially on your shoulders, elbows, knees, toes, or buttocks. Your skin might also heal more slowly than usual. Talk to your doctor before you have any kind of surgery, because your dose of this medicine might need to be changed.

  • For people who have diabetes: Succimer may affect the results of some urine tests for ketones (such as Ketostix®). Ask your doctor what kind of ketone test you should use while you are using succimer.

  • For Wilson€™s disease, you might need to use this medicine for one to three months before you notice any improvement. The symptoms of Wilson€™s disease might get worse when you first start using this medicine. If your symptoms get very bad or keep getting worse, tell your doctor.

  • Some people have too much heavy metal in their bodies because they were exposed to it, such as in the home or at work. The metal could still be in their surroundings. If this is your situation, then you must get rid of the metal or learn how to protect yourself. This medicine will not protect you from a heavy metal that you are still being exposed to. Find out how you were exposed. Ask your health caregiver about the best ways to get rid of or avoid the heavy metal that caused the problem.

  • Tell your doctor if you are also using any vitamin, mineral, or iron supplements.

  • Do not take any other medicine at the same time you take penicillamine. Always allow at least 1 hour between the time you take penicillamine and the time you take other medicines. If you are using a different chelating medicine, ask your doctor.

  • Make sure your doctor knows if you are also using phenylbutazone or medicine to treat malaria, such as mefloquine, quinine, quinidine, chloroquine, atovaquone/proguanil, Lariam®, Malarone®, Aralen®.

  • Tell your doctor if you have ever used a chelating agent before.

  • Make sure your doctor knows if you are also using any other medicines to lower the amount of metal in your body.

  • Make sure your doctor knows if you are also using any other medicines to lower the amount of metal in your body, such as penicillamine (Cuprimine®).

  • You must also get rid of the lead or other heavy metal that made you sick. Find out how you have been exposed to a heavy metal. This medicine will not protect you from a heavy metal that you are still being exposed to. Ask your health caregiver about the best ways to get rid of or avoid the heavy metal that caused the problem.

  • Make sure your doctor knows if you are breastfeeding. You probably should not breastfeed while you are being treated with this medicine, because the metal in your body and the medicine will both be in your breast milk.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Your doctor will also need to check your blood after you stop using the medicine, to make sure the metal is gone from your body.

  • Tell your doctor if you have ever used succimer before, especially if you had any side effects to it.

  • For people who have diabetes: This medicine may affect the results of some urine tests for ketones (such as Ketostix®). Ask your doctor what kind of ketone test you should use while you are using succimer.

Chemet side effects

Serious Side Effects

  • Skin rash, itching, redness (at any time during treatment, or after treatment stops).

  • Unusual bleeding, bruising, or weakness.

  • Seizures, clumsiness.

  • Scaly, red, or flaky patches on your skin, or skin blisters (especially in your mouth).

  • Muscle weakness, drooping eyelids, double vision, trouble seeing.

  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Bloody or cloudy urine.

  • Fever, by itself or with chills or sore throat.

  • Trouble breathing, coughing up blood, unexplained cough or wheezing.

  • Seizures, trouble breathing, clumsiness.

  • Fever, chills, cough, sore throat, and body aches.

  • Skin rash or blisters.

Less Serious Side Effects

  • Metallic taste in your mouth.

  • Dizziness, sleepiness.

  • Nausea, vomiting, diarrhea, loss of appetite.

  • Nausea, vomiting, diarrhea, stomach pain, loss of appetite or ability to taste.

  • Sores, swelling, cracks, or white patches on your lips, mouth, or throat.

  • Metallic taste in your mouth.

  • Skin wrinkles, small white spots.

  • Ringing in your ears.

  • Unusual muscle pain, or joint pain or swelling.

  • Dizziness, sleepiness.

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