What is Cholestyramine: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Cholestyramine overview

BRAND NAMES:

  • Prevalite, Questran, Questran Light

Generic Names:

  • Cholestyramine

Uses:

  • Lowers high cholesterol levels. Also treats severe itching caused by liver disease.

Therapeutic Classes:

  • Antihyperlipidemic, Exchange Resin, Urinary Stone Agent

Forms:

  • Powder for Suspension, Packet

How it’s taken:

  • By mouth

What is Cholestyramine used for?

What form(s) does Cholestyramine come in

  • Powder for Suspension

  • Packet

What are common Cholestyramine doses?

  • Packet 1 Packet

  • Packet 4GM

  • Can 378GM of 4GM/DOSE

  • Box 60 Packet

  • Bottle 1GM of

  • Bottle 5GM of

  • Bottle 25GM of

  • Bottle 100GM of

  • Bottle 500GM of

  • Bottle 1000GM of

Common Cholestyramine prescriptions

  • Cholestyramine
    378gm of 4gm/dose bottle

  • Cholestyramine
    60 packet box

  • Cholestyramine
    378gm of 4gm/dose can

  • Cholestyramine
    4gm packet

How to take Cholestyramine

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Take this medicine just before eating or with meals.

  • You should not use the powder in dry form. Mix in 4 to 6 ounces of water, fruit juice, or milk until completely dissolved. Drink this mixture right away. Rinse the glass with more liquid and drink that too, so you get all of the medicine.

  • You may also mix the powder medicine in thin soup, with soft fruits such as fruit cocktail or crushed pineapple, or with milk in breakfast cereal.

  • Drink several glasses of liquids each day while using this medicine.

  • Take this medicine just before eating or with meals.

  • You should not use the powder in dry form. Mix in 4 to 6 ounces of water, fruit juice, or milk until completely dissolved. Drink this mixture right away. Rinse the glass with more liquid and drink that too, so you get all of the medicine.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Drink several glasses of liquids each day while using this medicine.

  • You may also mix the powder medicine in thin soup, with soft fruits such as fruit cocktail or crushed pineapple, or with milk in breakfast cereal.

What to do if you miss a dose of Cholestyramine

  • Take the missed dose as soon as possible.

  • Skip the missed dose if it is almost time for your next regular dose.

  • You should not use two doses at the same time.

Cholestyramine contraindications

  • You should not use this medicine if you have had an allergic reaction to cholestyramine.

Cholestyramine warnings

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have thyroid problems, diabetes, gallbladder disease, stomach problems, heart disease, kidney disease, or liver disease.

  • Questran Light® contains aspartame (Nutrasweet®). If you have phenylketonuria you should avoid using this product.

  • Before you stop using this medicine, talk with your doctor.

  • This medicine is used with diet, exercise, and weight loss in overweight patients to control high cholesterol levels. To lower and keep your cholesterol normal, all of these are important.

Cholestyramine interactions

  • Make sure your doctor knows if you are also using Coumadin®.

  • Cholestyramine may change the way many other medicines work. Take other medicines 1 hour before or 4 to 6 hours after you take cholestyramine.

  • Talk with your doctor or pharmacist if you need help deciding the best time to take your medicines.

  • This medicine is used with diet, exercise, and weight loss in overweight patients to control high cholesterol levels. To lower and keep your cholesterol normal, all of these are important.

Cholestyramine side effects

Serious Side Effects

  • Rash or hives

  • Wheezing or trouble breathing.

  • Unusual bleeding such as nosebleeds or bleeding gums

  • Severe stomach pain

Less Serious Side Effects

  • Upset stomach

  • Heartburn, gas or bloating

  • Constipation

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