What is Darzalex: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Jan 25, 2021

Darzalex overview

BRAND NAMES:

  • Darzalex

Generic Names:

  • Darzalex

Uses:

  • Treats multiple myeloma.

Therapeutic Classes:

  • Antineoplastic Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Darzalex used for?

Darzalex is a monoclonal antibody that is used to treat multiple myeloma (bone marrow cancer). Darzalex works by blocking a certain protein in the body that can affect tumor cell growth.

What form(s) does Darzalex come in

  • Injectable

What are common Darzalex doses?

  • Vial 20ML of 400MG/20ML

Common Darzalex prescriptions

  • Darzalex
    20ml of 400mg/20ml vial

  • Darzalex
    5ml of 100mg/5ml vial

How to take Darzalex

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • You may be given other medicines (including allergy medicine, antiviral medicine, fever medicine, or steroid) before and after receiving this infusion.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

  • You may be given other medicines (including allergy medicine, antiviral medicine, fever medicine, or steroid) before and after receiving this infusion.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

What to do if you miss a dose of Darzalex

Darzalex contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to daratumumab, or if you are pregnant.

Darzalex warnings

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results. Tell your doctor that you are receiving this medicine before you receive a blood transfusion.

  • Injection routeIt is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use effective birth control during treatment and for at least 3 months after the last dose.

  • Tell your doctor if you are breastfeeding, or if you have liver disease (including hepatitis B infection), or a history of shingles (herpes zoster infection) or lung or breathing problems.

  • This medicine may cause an infusion reaction, which can be life-threatening.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Darzalex interactions

  • Injection routeIt is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use effective birth control during treatment and for at least 3 months after the last dose.

  • Tell your doctor if you are breastfeeding, or if you have a history of herpes zoster infection or lung or breathing problems.

  • This medicine may cause an infusion reaction, which can be life-threatening.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Darzalex side effects

Serious Side Effects

  • Rapid weight gain, swelling of your hands, ankles, or feet

  • Unusual bleeding, bruising, or weakness

  • Lightheadedness, dizziness, fainting

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Chest pain, trouble breathing, fast, slow, or uneven heartbeat

  • Fever, chills, cough, sore throat, body aches, stuffy or runny nose

  • Nausea, vomiting

Less Serious Side Effects

  • Back pain

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

  • Tiredness

  • Constipation, diarrhea, loss of appetite

  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet