Durolane is a brand-name gel that relieves knee pain in people with osteoarthritis. The gel contains hyaluronic acid, a naturally occurring component of cartilage and joint fluid. Durolane is not a medication but a medical device. Doctors do not prescribe it and patients do not take doses. Instead, an orthopedist, doctor, or healthcare professional injects the gel into the knee joint to provide cushioning and lubrication.
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Durolane overview
BRAND NAMES:
Durolane
Generic Names:
Hyaluronic acid
Uses:
Treats osteoarthritis knee pain.
Therapeutic Classes:
Musculoskeletal agent, cartilaginous defect repair agent, viscosupplementation agent, class III medical device
Forms:
Injectable
How it’s taken:
Intra-articular injection
What is Durolane used for?
Durolane is a gel injected into the joint space of the knee to relieve osteoarthritis pain in people who have not been helped by conservative treatments or simple pain relievers like acetaminophen.
What form(s) does Durolane come in
Prefilled syringe
3 mL of 20 mg/mL
What are common Durolane doses?
For osteoarthritis knee pain: 3 mL (60 mg hyaluronic acid) injected into the joint space in the knee (intra-articular injection)
Common Durolane prescriptions
Durolane
3ml of 60mg/3ml syringe
How to take Durolane
A doctor or other healthcare provider will inject this medication into your knee joint. Injections are made in a doctor’s office or clinic.
A single dose (3 mL of 20 mg/mL) is injected into each affected knee.
The entire procedure should take about 10 to 15 minutes from start to finish.
Follow all the doctor’s instructions for post-injection care. You will probably be given a sheet of instructions. These instructions usually include:
Avoid strenuous activities, heavy lifting, or standing for long periods of time for 48 hours after the injection.
Keep the area dry and covered with a bandage for 24 hours.
Do not put topical creams or medications on the injection site for 24 hours.
Avoid bathing, hot tubs, or swimming for 24 hours.
Avoid heat pads or heat packs for 24 hours.
Cold packs are permitted but may have time limitations.
Continue taking medications including pain medications.
The injection should provide pain relief for 26 weeks.
The doctor will determine the need for future injections.
What to do if you miss a dose of Durolane
A physician will inject Durolane. One injection is enough for 26 weeks of pain relief.
There are no missed doses.
Durolane contraindications
This medicine is not right for everyone.
The clinician will not inject Durolane in anyone who has:
Known allergies to hyaluronic acid
Joint infections of the knee
Skin infections or skin disease at the injection site
Durolane warnings
Before getting the injection, tell the physician if you are pregnant, breastfeeding, or have:
Knee joint infections
Skin disease or skin infections around the knee
After the injection, call the doctor if you experience pain or swelling in the knee joint that doesn’t improve or gets worse.
Durolane interactions
Hyaluronic acid injections do not have significant drug interactions.
Durolane side effects
Serious side effects
Persistent or worsening knee pain, swelling, muscle pain, difficulty moving the joint
Allergic reaction: Itching, hives, skin redness, swelling in the face, mouth, or tongue, trouble breathing
Less serious side effects
Temporary joint pain or swelling where the medicine is injected
Mild skin redness, swelling, itching, or pain at the injection site
Sources:
About hyaluronate injections in your knee, Memorial Sloan Kettering Cancer Institute
Durolane, Bioventus
Durolane patient information, Food and Drug Administration (FDA)
Home care after a hyaluronic acid injection, UW Health
Hyaluronic acid, American College of Rheumatology
Hyaluronic acid, StatPearls
Hyaluronic acid (injection route), Mayo Clinic
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