What is Epinephrine anaphylaxis: Uses, Warnings & Interactions

How to take Epinephrine anaphylaxis

• Keep the autoinjector and prefilled syringe in its carrier tube or case to protect it from damage. This tube or case is not waterproof. If you accidentally drop it, check for damage or leaks.

• Throw away expired, unwanted, or unused EpiPen® or EpiPen Jr® in an FDA-cleared sharps container. Do not throw it away in the trash bin.

• If you are using the epinephrine injection in a child, make sure to hold his leg firmly in place and limit movement before and during an injection.

• Check your injection kits regularly to make sure the liquid has not changed color. It should be clear and colorless. Do not use the autoinjector, prefilled syringe, or vial if the liquid is discolored or cloudy, or if there are particles in it. You should not use the autoinjector or vial if the expiration date has passed.

• For treatment of low blood pressure with septic shock: A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle placed into one of your veins.

• Your doctor should teach you how and when to inject this medicine. Each injection kit contains a single-use dose of medicine prescribed for you.

• Give yourself a shot right away if you start to have a severe allergic reaction.

• Inject this medicine into the muscle on the outside of your thigh only. Never inject this medicine into a vein, into the muscles of your buttocks, or into your fingers, toes, hands, or feet.

• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

• This medicine might come with an autoinjector trainer so you can practice giving the medicine before you have an actual allergic reaction. The autoinjector trainer is gray (for EpiPen® or EpiPen Jr®) or beige (for Adrenaclick®) and does not contain any medicine or needle.

• Inspect the autoinjector from time to time before needing it to ensure the blue safety release (EpiPen® or EpiPen Jr®) is not raised and that the autoinjector can be easily remove from the carrier tube.

• Do not remove the blue safety release (EpiPen® or EpiPen Jr®) or the gray end caps (Adrenaclick®) on the autoinjector until you are ready to use it. Do not put your thumb, fingers, or hand over the orange (EpiPen® or EpiPen Jr®) or red (Adrenaclick®) tip of the autoinjector or over the needle of the Symjepi® prefilled syringe.

• If you are about to use the autoinjector, pull up straight the blue safety release (EpiPen® or EpiPen Jr®) with one hand and hold the pen with the other hand. Do not flip the blue safety release off using the thumb or by pulling it sideways, or by bending and twisting it. This may activate the device by accident (a "click" is heard, the orange needle is extended, and the window is blocked), making it unusable in case of an emergency. Push the needle end (orange end of the autoinjector) firmly against the outer thigh until it "clicks". This signals that the injection has started. The autoinjector needs to stay in place for a minimum of 3 seconds following activation.

• If you use the Symjepi® prefilled syringe, do not remove the needle cap until you are ready to use it.

• You may need to use more than one injection if your allergic reaction does not get better after the first shot. Your doctor will give you additional doses if you need more than 2 injections. If you are using Adrenalin®, you may inject every 5 to 10 minutes as needed.

• You may inject the medicine through your clothing, if you need to.

• Some liquid will remain in the autoinjector or vial after the medicine has been injected. This medicine cannot be reused. Give your used autoinjector or vial to your healthcare provider when you seek medical care.

• Carry this medicine with you at all times for emergency use in case you have a severe allergic reaction.

• Make sure family members or other people you are with know how to inject the medicine in case you are not able to do it yourself.

• Store the injection kit at room temperature, away from heat, moisture, and direct light. Do not store the medicine in the refrigerator or freezer, or inside a car.

• If you use the Symjepi® prefilled syringe, do not remove the needle cap until you are ready to use it.

• Some liquid will remain in the autoinjector or vial after the medicine has been injected. This medicine cannot be reused. Give your used autoinjector or vial to your healthcare provider when you seek medical care.

• Inspect the autoinjector from time to time before needing it to ensure the blue safety release (EpiPen® or EpiPen Jr®) is not raised and that the autoinjector can be easily remove from the carrier tube.

• Store the injection kit at room temperature, away from heat, moisture, and direct light. Do not store the medicine in the refrigerator or freezer, or inside a car.

• Give yourself a shot right away if you start to have a severe allergic reaction.

• You may inject the medicine through your clothing, if you need to.

• This medicine might come with an autoinjector trainer so you can practice giving the medicine before you have an actual allergic reaction. The autoinjector trainer is gray (for EpiPen® or EpiPen Jr®) or beige (for Adrenaclick®) and does not contain any medicine or needle.

• If you are about to use the autoinjector, pull up straight the blue safety release (EpiPen® or EpiPen Jr®) with one hand and hold the pen with the other hand. Do not flip the blue safety release off using the thumb or by pulling it sideways, or by bending and twisting it. This may activate the device by accident (a "click" is heard, the orange needle is extended, and the window is blocked), making it unusable in case of an emergency. Push the needle end (orange end of the autoinjector) firmly against the outer thigh until it "clicks". This signals that the injection has started. The autoinjector needs to stay in place for a minimum of 3 seconds following activation.

• Keep the autoinjector and prefilled syringe in its carrier tube or case to protect it from damage. This tube or case is not waterproof. If you accidentally drop it, check for damage or leaks.

• Your doctor should teach you how and when to inject this medicine. Each injection kit contains a single-use dose of medicine prescribed for you.

• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

• Do not remove the blue safety release (EpiPen® or EpiPen Jr®) or the gray end caps (Adrenaclick®) on the autoinjector until you are ready to use it. Do not put your thumb, fingers, or hand over the orange (EpiPen® or EpiPen Jr®) or red (Adrenaclick®) tip of the autoinjector or over the needle of the Symjepi® prefilled syringe.

• Make sure family members or other people you are with know how to inject the medicine in case you are not able to do it yourself.

• If you are using the epinephrine injection in a child, make sure to hold his leg firmly in place and limit movement before and during an injection.

• Throw away expired, unwanted, or unused EpiPen® or EpiPen Jr® in an FDA-cleared sharps container. Do not throw it away in the trash bin.

• Check your injection kits regularly to make sure the liquid has not changed color. It should be clear and colorless. Do not use the autoinjector, prefilled syringe, or vial if the liquid is discolored or cloudy, or if there are particles in it. You should not use the autoinjector or vial if the expiration date has passed.

• For treatment of low blood pressure with septic shock: A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle placed into one of your veins.

• Carry this medicine with you at all times for emergency use in case you have a severe allergic reaction.

• Inject this medicine into the muscle on the outside of your thigh only. Never inject this medicine into a vein, into the muscles of your buttocks, or into your fingers, toes, hands, or feet.

• You may need to use more than one injection if your allergic reaction does not get better after the first shot. Your doctor will give you additional doses if you need more than 2 injections. If you are using Adrenalin®, you may inject every 5 to 10 minutes as needed.

What to do if you miss a dose of Epinephrine anaphylaxis

Epinephrine anaphylaxis contraindications

• A severe allergic reaction can be life-threatening, so there is no reason this medicine should not be used.

Epinephrine anaphylaxis warnings

• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, heart disease, asthma, diabetes, heart rhythm problems, high blood pressure, an overactive thyroid, or Parkinson disease.

• This medicine may cause the following problems:Serious skin infections at the injection site (including necrotizing fasciitis, myonecrosis)High blood pressurePulmonary edema (fluid in the lungs)Kidney problemsHeart and heart rhythm problemsHigh blood sugar

• A severe allergic reaction is a medical emergency. Go to an emergency room as soon as possible, even if you feel better after you use this medicine.

• Do not inject this medicine into your buttocks, hands, fingers, toes, or feet. Go to the emergency room right away if you accidently inject epinephrine into any part of your body other than your thigh. Epinephrine reduces blood flow, and this could damage areas that have small blood vessels, including the hands and feet.

• Keep all medicine out of the reach of children. Never share your medicine with anyone.

• Trouble breathing

Epinephrine anaphylaxis interactions

• Some foods and medicines can affect how epinephrine works. Tell your doctor if you are using any of the following:Clonidine, digoxin, doxapram, levothyroxine, oxytocin, phentolamine, theophyllineBlood pressure medicine (including propranolol)Certain allergy medicines (including chlorpheniramine, diphenhydramine, tripelennamine)Diuretic (water pill)Ergot medicinesMedicine to treat depression (including MAO inhibitors, TCAs)Medicine for heart rhythm problemsNitrate medicineSteroid medicineThyroid medicine

• A severe allergic reaction is a medical emergency. Go to an emergency room as soon as possible, even if you feel better after you use this medicine.

• Do not inject this medicine into your hands or feet. Go to the emergency room right away if you accidently inject epinephrine into any part of your body other than your thigh. Epinephrine reduces blood flow, and this could damage areas that have small blood vessels, such as hands and feet.

• Keep all medicine out of the reach of children. Never share your medicine with anyone.