What is Esomeprazole Sodium: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 31, 2020

Esomeprazole Sodium overview

BRAND NAMES:

  • NexIUM I.V.

Generic Names:

  • Esomeprazole Sodium

Uses:

  • Treats gastroesophageal reflux disease (GERD) with erosive esophagitis (damaged esophagus). Lowers the risk of bleeding after endoscopy in patients with ulcers. This medicine is a proton pump inhibitor (PPI).

Therapeutic Classes:

  • Gastric Acid Secretion Inhibitor

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Esomeprazole Sodium used for?

What form(s) does Esomeprazole Sodium come in

  • Injectable

What are common Esomeprazole Sodium doses?

  • Solution Reconstituted 40MG

Common Esomeprazole Sodium prescriptions

  • Esomeprazole Sodium
    20mg solution reconstituted

  • Esomeprazole Sodium
    40mg solution reconstituted

How to take Esomeprazole Sodium

  • Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Your doctor will give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

What to do if you miss a dose of Esomeprazole Sodium

Esomeprazole Sodium contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to esomeprazole or similar medicines.

Esomeprazole Sodium warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, lupus, stomach or bowel cancer, or osteoporosis.

  • This medicine may cause the following problems:Kidney problemsIncreased risk of broken bones in the hip, wrist, or spine (more likely if received several times per day or longer than 1 year)LupusFundic gland polyps (abnormal growth in the upper part of your stomach)

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Severe diarrhea that does not go away, fever

  • Stomach pain, nausea, vomiting, weight loss

Esomeprazole Sodium interactions

  • Do not use this medicine if you are also using it together with rilpivirine or other products containing rilpivirine.

  • Some medicines can affect how esomeprazole works. Tell your doctor if you are using any of the following:Atazanavir, cilostazol, citalopram, dasatinib, digoxin, erlotinib, itraconazole, ketoconazole, methotrexate, mycophenolate mofetil, nelfinavir, nilotinib, rifampin, ritonavir, saquinavir, St John's wort, tacrolimus, voriconazoleBlood thinner (including clopidogrel or warfarin)Diuretic (water pill)Iron supplements

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Esomeprazole Sodium side effects

Serious Side Effects

  • Severe diarrhea that does not go away

  • Seizures, dizziness, muscle spasms, cramps, or twitching

  • Joint pain, rash on your cheeks or arms that gets worse in the sun

  • Stomach pain, nausea, vomiting, weight loss, bloody or black stool

  • Fever, joint pain, swelling in your body, unusual weight gain, changes in how much or how often you urinate

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

  • Fast, slow, pounding, or uneven heartbeat

Less Serious Side Effects

  • Gas

  • Redness, pain, itching, swelling, or a lump under your skin where the needle is placed

  • Headache