Flagyl is the brand-name version of metronidazole, a mainstay in the treatment of many types of bacterial and parasite infections. While metronidazole is available in a variety of strengths and dosage formats, Flagyl can only be purchased as 375 mg capsules. Flagyl 375 is limited to parasite infections, so most people taking metronidazole are prescribed generic versions.
Flagyl, Flagyl 375
Metronidazole
Treats bacterial and protozoal infections
Antibiotics, nitroimidazole antibiotics, anaerobicides, gynecological antibiotics, antiprotozoals, amebicides
Tablet
By mouth
Healthcare providers prescribe Flagyl 375 mg capsules to treat trichomoniasis and amoeba infections. For bacterial infections in the body, healthcare professionals usually prescribe generic metronidazole.
Capsule
375 mg
For trichomoniasis: 375 mg capsule taken twice daily for seven days
For amoeba infections:
In adults: 750 mg capsule taken three times daily for 5–10 days
In children (generic metronidazole): 35–50 mg daily taken in three divided doses for 10 days
For bacterial infections (generic metronidazole): 7.5 mg/kg every six hours for 7–10 days
Find more detailed information about Flagyl dosage, strengths, and formats here.
Flagyl
375mg capsule
Flagyl
250mg tablet
Flagyl
500mg tablet
Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.
Flagyl capsules can be taken with a meal or on an empty stomach.
Taking the capsule with food or milk will minimize stomach upset and other problems.
Swallow the capsule whole with a full glass of water.
Store Flagyl capsules in a closed container at room temperature.
Take a dose as soon as you remember.
If it is almost time for your next dose, wait until then and take a regular dose.
Do not take extra medicine to make up for a missed dose.
This medicine is not right for everyone.
Do not use it if you have had an allergic reaction to metronidazole or similar medicines.
This medicine is also contraindicated for trichomoniasis in the first three months of pregnancy.
Metronidazole is also contraindicated in anyone who:
Has had a psychotic reaction when taking the alcoholism treatment disulfiram
Has a rare hereditary disorder called Cockayne syndrome
Tell any doctor or other healthcare provider who treats you that you are taking Flagyl capsules.
The prescriber may request follow-up visits or blood tests. Keep all appointments.
Call your doctor if your symptoms do not improve or if they get worse.
Before taking Flagyl, make sure the prescriber knows if you are pregnant, breastfeeding, or if you have:
Kidney problems
Liver problems
A yeast infection
A genetic disorder called Cockayne syndrome
A history of blood disorders
A history of seizures
Metronidazole can cause serious problems, including:
Nervous system disorders, including brain disorders, seizures, optic nerve damage, and peripheral nerve damage
Liver poisoning, liver damage, or liver failure
Severe skin reactions
Trichomoniasis is a sexually transmitted disease, so you should take measures to avoid reinfection from your sexual partner during and after Flagyl treatment.
The doctor may wish to treat your sexual partner even if there are no symptoms.
Use a condom for sexual intercourse.
To avoid drug interactions, tell the prescribing healthcare provider about all prescription drugs, over-the-counter medications, and supplements you take.
Tell other healthcare providers you are using this medicine before they prescribe new medications.
Metronidazole cannot safely be taken at the same time as the alcoholism treatment disulfiram. That drug must be stopped at least two weeks before the first dose of metronidazole is taken.
To avoid potentially significant drug interactions, make sure the prescriber knows if you’re taking:
Blood thinners
HIV/AIDS drugs called protease inhibitors
Macrolide antibiotics such as clarithromycin
Heart rhythm drugs
Busulfan, cimetidine, cyclosporine, lithium, mycophenolate, phenobarbital, phenytoin
Do not drink alcohol or use medicine that contains alcohol or propylene glycol while using this medicine and for at least three days after treatment.
Some foods contain propylene glycol, so check ingredient labels.
Find more detailed information about metronidazole interactions to avoid here.
Talk to a doctor if you notice any signs or symptoms of a possible serious side effect, including:
Confusion, memory problems, drowsiness, agitation, behavior changes, hallucinations, involuntary muscle movements
Headache, sleepiness, stiff neck, light sensitivity, fever
Seizures
Vision changes, vision loss
Numbness, tingling, or burning pain in your hands, arms, legs, or feet
Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
Fever, chills, cough, sore throat, body aches
Blistering, peeling, red skin rash
Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Yeast infections
Headache
Vaginitis
Nausea
Metallic or unpleasant taste in your mouth, taste distortions
Find more detailed information about metronidazole side effects here.
Flagyl metronidazole capsule prescribing information, DailyMed (NIH National Library of Medicine)
Metronidazole, StatPearls\
Metronidazole drug summary, Prescriber’s Digital Reference (PDR)
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