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Drug Info The Mix-Up

Can you drink on doxycycline?

A drink or two is usually okay, but more than that can cause serious issues. Here’s what to know before raising a glass.
Gerardo Sison medical writer headshot
By | Oct. 31, 2025
Two women holding glasses of wine - doxycycline and alcohol

Key takeaways

  • Most people can safely have a drink or two while taking doxycycline in moderation. 

  • Heavy drinking can worsen side effects like nausea and stomach pain, and delay recovery from an infection.

  • Those with liver problems or older adults may have a higher risk of side effects when mixing alcohol and doxycycline.

In this article:

Doxycycline is a commonly prescribed antibiotic in the tetracycline class, available as an oral tablet or capsule. It’s used to treat a wide range of bacterial infections, including urinary tract infections (UTIs) and sexually transmitted infections (STIs) such as chlamydia. It also helps prevent malaria in travelers and manage acne or other skin problems caused by bacteria. 

While moderate alcohol consumption, typically one or two drinks, is unlikely to cause serious issues for most people, combining the two isn’t entirely without risk. Understanding how alcohol can affect the effectiveness and your overall health is important before mixing them.

Can you drink while taking doxycycline?

Drinking in moderation while taking doxycycline is generally safe for most people. Alcohol isn’t known to decrease the effectiveness of doxycycline or cause severe interactions. Moderate drinking means no more than two drinks per day for men and no more than one drink per day for women. Drinking past those limits may cause increased side effects, which means heavy drinking and chronic alcohol use should be avoided while taking doxycycline. 

However, whether you feel like drinking may vary depending on why you’re taking this antibiotic. It’s normal to feel tired, weak, or run down while your body is trying to heal from an infection, decreasing your desire to raise a glass with friends.

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What happens if you mix doxycycline and alcohol?

If you’re feeling mostly recovered and ready to have a glass of wine, just know that drinking alcohol may increase the risk of side effects of doxycycline. Everyone is different, with some people experiencing more severe reactions than others.

Nausea or vomiting

An upset stomach is a common side effect of doxycycline. It’s also known to be hard on the stomach, sometimes causing nausea and vomiting. People who drink alcohol while taking doxycycline may experience increased nausea and vomiting. Even small amounts of beer, wine, or liquor can trigger these side effects.

Diarrhea

Diarrhea is another possible side effect when mixing alcohol and doxycycline. Doxycycline kills harmful bacteria but can also affect the balance of good bacteria. Alcohol can make this imbalance worse, disrupting the good and bad bacteria in the digestive system. 

Inflammation of the esophagus

Doxycycline can irritate your esophagus, especially if you don’t drink enough water with it. That’s why it’s recommended to take doxycycline with a full glass of water and stay upright for at least 30 minutes after. Alcohol increases stomach acid, which can creep up and potentially worsen inflammation. 

Liver damage

Doxycycline and alcohol are both metabolized or processed by the liver. Reports have shown that doxycycline may cause liver injury in rare cases, and alcohol is known to cause liver problems, especially in those who drink heavily over time. The risk of liver toxicity may increase when mixing doxycycline and alcohol.

Slowed recovery from infection

Regular alcohol use can weaken the immune system and slow the immune response. Even just one night of binge drinking can reduce immune function for up to a day. As a result, it could take longer to recover from bacterial infections while taking doxycycline. Some studies suggest that certain alcoholic drinks, like wine, can decrease the antibiotic’s absorption and effectiveness. 

A chart showing the safety of combining doxycycline and alcohol

Are certain people at greater risk of side effects?

Some people may have a higher risk of side effects when mixing alcohol and doxycycline. Those with existing health issues, including liver problems, and older adults may experience more serious problems.

People with liver problems

People with existing liver problems, such as hepatitis, cirrhosis, or fatty liver disease, may have trouble processing doxycycline and alcohol. Healthcare professionals recommend completely avoiding alcohol for patients with liver problems. Adding doxycycline to the mix can add extra stress to an already damaged liver.

Older adults

Older adults break down alcohol and medications more slowly, allowing both to stay in the body longer and increasing the risk of side effects. Age-related liver and kidney changes can make mixing alcohol with doxycycline especially risky.

Always consult a healthcare provider about existing health conditions before drinking alcohol while taking doxycycline. 

How long after taking doxycycline can you drink alcohol?

The timing for drinking alcohol after doxycycline depends on how long the drug stays in your body. Doxycycline has a half-life of about 18 to 22 hours in healthy adults. Half-life is the time it takes for half of the drug to leave your system. 

For most people, it takes about five half-lives for a drug to completely clear from the body. For doxycycline, this means it can take around four to five days for the medication to be fully cleared. Waiting a few days after your last dose is generally enough, and moderate drinking during this time isn’t likely to cause problems.

Antacids or supplements that contain calcium, magnesium, aluminum, iron, or bismuth subsalicylate can affect the absorption of doxycycline. Therefore, it’s recommended to avoid taking these products within two hours before or after a dose of doxycycline.

Which antibiotics are not affected by alcohol?

Alcohol can sometimes interfere with antibiotics or worsen side effects like nausea, dizziness, or stomach upset. Still, many antibiotics can be taken safely with an occasional drink. Here’s how different types compare:

Some types of antibiotics are known to cause dangerous reactions with alcohol and should be avoided completely during treatment. The main culprits include Flagyl (metronidazole), Tindamax (tinidazole), Bactrim (trimethoprim/sulfamethoxazole), and certain cephalosporins like Cefotan (cefotetan) and Cefobid (cefoperazone). Combining these drugs with alcohol can trigger flushing, nausea, vomiting, and rapid heartbeat, causing a disulfiram-like reaction.

Each person responds differently to drug interactions between alcohol and antibiotics. Anyone taking antibiotics should talk with their healthcare provider about alcohol use during treatment.

The bottom line

For most people, an occasional drink won’t reduce the efficacy of doxycycline or cause severe side effects. However, those who drink larger amounts of alcoholic beverages might strain their body’s ability to process the medicine and increase the risk of adverse reactions, like stomach pain, nausea, and vomiting. Because everyone responds differently, it’s best to ask your healthcare provider or pharmacist for medical advice before mixing doxycycline with alcohol.

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