What is Gazyva: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Mar 27, 2022

Gazyva overview

BRAND NAMES:

  • Gazyva

Generic Names:

  • Gazyva

Uses:

  • Treats chronic lymphocytic leukemia (CLL) and follicular lymphoma.

Therapeutic Classes:

  • Antineoplastic Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Gazyva used for?

Gazyva is a prescription-only medication that is used in combination with other monoclonal antibody medications to treat chronic lymphocytic leukemia and follicular lymphoma. It works by boosting the immune system to prevent the growth of cancer cells.

What form(s) does Gazyva come in

  • Injectable

What are common Gazyva doses?

  • Vial 40ML of 1000MG/40ML

Common Gazyva prescriptions

  • Gazyva
    40ml of 1000mg/40ml vial

How to take Gazyva

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

What to do if you miss a dose of Gazyva

Gazyva contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to obinutuzumab.

Gazyva warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have low blood pressure, kidney disease, heart disease, lung problems, an infection, or a history of hepatitis B infection.

  • This medicine may cause the following problems:Reactivation of hepatitis B infectionProgressive multifocal leukoencephalopathy (a brain infection that can be life-threatening)Infusion reactionTumor lysis syndrome (electrolyte and metabolic problem that can be life-threatening)

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • Lightheadedness, dizziness, fainting

  • Unusual bleeding, bruising, or weakness

Gazyva interactions

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • This medicine may cause the following problems:Reactivation of hepatitis B infectionProgressive multifocal leukoencephalopathy (a brain infection that can be life-threatening)Infusion reactionTumor lysis syndrome (electrolyte and metabolic problem that can be life-threatening)

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Gazyva side effects

Serious Side Effects

  • Lightheadedness, dizziness, fainting

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Fever, chills, cough, sore throat, body aches

  • Confusion, problems with vision, speech, or walking

  • Unusual bleeding, bruising, or weakness

  • Diarrhea, nausea, vomiting, unusual tiredness

  • Dark urine or pale stools, nausea, loss of appetite, stomach pain, yellow skin or eyes

Less Serious Side Effects

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed