What is Gengraf: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Gengraf overview

BRAND NAMES:

  • Gengraf, Neoral, SandIMMUNE

Generic Names:

  • Cyclosporine Modified

Uses:

  • Helps prevent organ rejection after transplant surgery. Also treats rheumatoid arthritis and psoriasis.

Therapeutic Classes:

  • Immune Suppressant

Forms:

  • Capsule, Liquid Filled Capsule, Liquid

How it’s taken:

  • By mouth

What is Gengraf used for?

Gengraf is an immunosuppressants that works by weakening the immune system to help your body accept the new organ after a transplant surgery. It is prescribed to to prevent organ rejection in patients who have had a heart, liver or kidney transplant.

What form(s) does Gengraf come in

  • Capsule

  • Liquid Filled Capsule

  • Liquid

What are common Gengraf doses?

  • Capsule 25MG

  • Capsule 100MG

  • Bottle 50ML of 100MG/ML

Common Gengraf prescriptions

  • Gengraf
    50ml of 100mg/ml bottle

  • Gengraf
    100mg capsule

  • Gengraf
    25mg capsule

  • Gengraf
    30 capsules disp pack

How to take Gengraf

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Take this medicine the same way every day. This means take it at the same time and always take it with food or always without food.

  • Oral liquid instructions: Measure the oral liquid with the included dosing syringe. Wipe the syringe with a clean towel after use and replace the cover. Do not rinse the syringe or allow any water to get into the medicine container. Neoral® oral liquid may be added to a glass of room temperature apple juice or orange juice. Stir well, and drink the mixture right away. Add more juice to the glass and drink that too, so you get all of the medicine. Do not use a plastic cup.Sandimmune® oral liquid may be added to a glass of room temperature milk, chocolate milk, or orange juice. Stir well, and drink the mixture right away. Add more milk or juice to the glass and drink that too, so you get all of the medicine.

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in the original container at room temperature, away from heat and direct light. Do not store it in the refrigerator or freezer. Throw away any unused oral liquid 60 days after the bottle is opened for the first time.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Take this medicine the same way every day. This means take it at the same time and always take it with food or always without food.

  • Store the medicine in the original container at room temperature, away from heat and direct light. Do not store it in the refrigerator or freezer. Throw away any unused oral liquid 60 days after the bottle is opened for the first time.

  • Oral liquid instructions: Measure the oral liquid with the included dosing syringe. Wipe the syringe with a clean towel after use and replace the cover. Do not rinse the syringe or allow any water to get into the medicine container. Neoral® oral liquid may be added to a glass of room temperature apple juice or orange juice. Stir well, and drink the mixture right away. Add more juice to the glass and drink that too, so you get all of the medicine. Do not use a plastic cup.Sandimmune® oral liquid may be added to a glass of room temperature milk, chocolate milk, or orange juice. Stir well, and drink the mixture right away. Add more milk or juice to the glass and drink that too, so you get all of the medicine.

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

What to do if you miss a dose of Gengraf

Gengraf contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to cyclosporine or castor oil.

Gengraf warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, cancer, anemia, a bleeding disorder, high blood pressure, eye or vision problems, or a history of seizures.

  • This medicine may cause the following problems: Kidney problemsLiver problemsIncreased risk of infections, including rare and life-threatening infectionsIncreased risk of cancer, including skin cancer or cancer of the lymph nodes (lymphoma)High blood pressure

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

  • Do not stop using this medicine without talking to your doctor.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Seizures or tremors

  • Unusual bleeding, bruising, or weakness

Gengraf interactions

  • There are many drugs that can interact with cyclosporine. Make sure your doctor knows about all other medicines you are using.

  • You should not use cyclosporin if you are receiving other treatment for psoriasis, including PUVA or UVB therapy, coal tar, or radiation treatment.

  • Ask your doctor before you use any medicine, supplement, or salt substitute that contains potassium.

  • If you are using sirolimus, take it 4 hours after you use cyclosporine.

  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Gengraf side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Change in how much or how often you urinate, bloody urine

  • Confusion, weakness, uneven heartbeat, trouble breathing, or numbness in your hands, feet, or lips

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Rapid weight gain, swelling in your face, hands, feet, or lower legs

  • Fast heartbeat, dizziness, headache, vision changes

  • Seizures or tremors

  • Unusual bleeding, bruising, or weakness

  • Fever, chills, cough, sore throat, or body aches

Less Serious Side Effects

  • Increased hair growth, especially on your face

  • Swelling of your gums

  • Diarrhea, stomach pain