What is Glipizide-Metformin Hcl: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Glipizide-Metformin Hcl overview

BRAND NAMES:

  • Metaglip

Generic Names:

  • Glipizide-Metformin Hcl

Uses:

  • Treats type 2 diabetes.

Therapeutic Classes:

  • Hypoglycemic, Biguanide/Sulfonylurea Combination

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Glipizide-Metformin Hcl used for?

What form(s) does Glipizide-Metformin Hcl come in

  • Tablet

What are common Glipizide-Metformin Hcl doses?

  • Tablet 5-500MG

  • Tablet 2.5-500MG

  • Tablet 2.5-250MG

Common Glipizide-Metformin Hcl prescriptions

  • glipiZIDE-metFORMIN HCl
    2.5-250mg tablet

  • glipiZIDE-metFORMIN HCl
    2.5-500mg tablet

  • glipiZIDE-metFORMIN HCl
    5-500mg tablet

How to take Glipizide-Metformin Hcl

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Oral routeIt is best to take this medicine with food or milk.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Oral routeIt is best to take this medicine with food or milk.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

What to do if you miss a dose of Glipizide-Metformin Hcl

Glipizide-Metformin Hcl contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to glipizide or metformin, or if you have kidney disease or metabolic acidosis.

Glipizide-Metformin Hcl warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, heart or blood vessel problems, congestive heart failure, adrenal or pituitary gland problems, or G6PD deficiency.

  • This medicine may cause the following problems:Lactic acidosis (rare, but serious)Higher risk of heart or blood vessel problemsLow blood sugar

  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using it before you have surgery, an X-ray, a CT scan, or other medical tests.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Unusual tiredness or weakness

Glipizide-Metformin Hcl interactions

  • Some foods and medicines can affect how glipizide/metformin works. Tell your doctor if you are using aspirin, chloramphenicol, cimetidine, fluconazole, isoniazid, miconazole, niacin, phenytoin, probenecid, trimethoprim, vancomycin, blood pressure medicines, an NSAID pain or arthritis medicine, an MAO inhibitor, a sulfa medicine, estrogens, birth control pills, thyroid medicine, warfarin or another blood thinner, a diuretic (water pill), a steroid medicine, or a phenothiazine medicine.

  • If you are also taking colesevelam, take it at least 4 hours after you take glipizide/metformin.

  • Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using it before you have surgery, an X-ray, a CT scan, or other medical tests.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Glipizide-Metformin Hcl side effects

Serious Side Effects

  • Confusion, fast heartbeat, increased hunger, shakiness, sweating

  • Unusual tiredness or weakness

  • Blurred vision, changes in vision

  • Trouble breathing, lightheadedness, dizziness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Stomach pain, nausea, vomiting, muscle pain or cramping

Less Serious Side Effects

  • Mild nausea, diarrhea, or stomach upset

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