What is Gralise: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Gralise overview

BRAND NAMES:

  • SmartRx Gaba Kit, Smart RX Gaba-V, FusePaq Fanatrex, Gralise, Neurontin, Neurontin, Gralise, Gralise Starter Pack, Neurontin

Generic Names:

  • Gralise

Uses:

  • Treats seizures and pain caused by shingles.

Therapeutic Classes:

  • Anticonvulsant, Neuropathic Pain Agent

Forms:

  • Capsule, Liquid, Tablet

How it’s taken:

  • By mouth

What is Gralise used for?

What form(s) does Gralise come in

  • Capsule

  • Liquid

  • Tablet

What are common Gralise doses?

  • Tablet 300MG

  • Tablet 600MG

Common Gralise prescriptions

  • Gralise
    90 tablets bottle

  • Gralise
    300mg tablet

  • Gralise
    450mg tablet

  • Gralise
    600mg tablet

  • Gralise
    750mg tablet

  • Gralise
    900mg tablet

How to take Gralise

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. If you have epilepsy, do not allow more than 12 hours to pass between doses.

  • Capsule: Swallow the capsule whole with plenty of water. Do not open, crush, or chew it.

  • Gralise® tablet: Swallow the tablet whole . Do not crush, break, or chew it.

  • Neurontin® tablet: If you break a tablet into 2 pieces, use the second half as your next dose. Do not use the half-tablet if the whole tablet has been cut or broken after 28 days.

  • Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the Neurontin® oral liquid in the refrigerator. Do not freeze.

  • Neurontin® tablet: If you break a tablet into 2 pieces, use the second half as your next dose. Do not use the half-tablet if the whole tablet has been cut or broken after 28 days.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Gralise® tablet: Swallow the tablet whole . Do not crush, break, or chew it.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • Capsule: Swallow the capsule whole with plenty of water. Do not open, crush, or chew it.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the Neurontin® oral liquid in the refrigerator. Do not freeze.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. If you have epilepsy, do not allow more than 12 hours to pass between doses.

What to do if you miss a dose of Gralise

Gralise contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to gabapentin.

Gralise warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney problems (including patients receiving dialysis) or lung problems. Tell your doctor if you have a history of depression or mental health problems.

  • This medicine may cause the following problems:Drug reaction with eosinophilia and systemic symptoms (DRESS) or multiorgan hypersensitivity, which may damage the liver, kidney, blood, heart, or musclesChanges in mood or behavior, including suicidal thoughts or behaviorRespiratory depression (serious breathing problem that can be life-threatening), when used with narcotic pain medicines

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Unusual moods or behaviors, thoughts of hurting yourself, feeling depressed

Gralise interactions

  • Some medicines can affect how gabapentin works. Tell your doctor if you also using hydrocodone or morphine.

  • If you take an antacid, wait at least 2 hours before you take gabapentin.

  • Do not drink alcohol while you are using this medicine.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are also using lorazepam, oxycodone, or zolpidem.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Gralise side effects

Serious Side Effects

  • Unusual moods or behaviors, thoughts of hurting yourself, feeling depressed

  • Rash, swollen or tender glands in the neck, armpit, or groin

  • Blistering, peeling, red skin rash

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Problems with coordination, shakiness, unsteadiness, unusual eye movement

  • Behavior problems, aggression, restlessness, trouble concentrating, moodiness (especially in children)

  • Change in how much or how often you urinate, bloody or cloudy urine

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blue lips, fingernails, or skin, chest pain, fast heartbeat, trouble breathing

  • Fever, chills, cough, sore throat, body aches

Less Serious Side Effects

  • Dizziness, drowsiness, sleepiness, tiredness