What is Lexiva: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Lexiva overview

BRAND NAMES:

  • Lexiva

Generic Names:

  • Fosamprenavir Calcium

Uses:

  • Treats HIV infection. This medicine does not cure HIV or AIDS, but combinations of drugs may slow the progress of the disease.

Therapeutic Classes:

  • Antiretroviral Agent

Forms:

  • Liquid, Tablet

How it’s taken:

  • By mouth

What is Lexiva used for?

What form(s) does Lexiva come in

  • Liquid

  • Tablet

What are common Lexiva doses?

  • Tablet 700MG

Common Lexiva prescriptions

  • Lexiva
    700mg tablet

How to take Lexiva

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Fosamprenavir is used together with other medicines to treat HIV infection. Take all of the medicines your doctor has prescribed at the right time of day and in the correct order. Do not stop using your medicine unless your doctor tells you to.

  • Oral liquid: Children should take the oral liquid with food. Adults should take it without food. Retake if you vomit within 30 minutes of taking the medicine. Shake the oral liquid well just before each use. Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Do not stop using this medicine without checking first with your doctor. If you stop the medicine even briefly, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is running low so you do not run out.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Oral liquid: Store in the refrigerator or at room temperature. Do not freeze.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Oral liquid: Store in the refrigerator or at room temperature. Do not freeze.

  • Do not stop using this medicine without checking first with your doctor. If you stop the medicine even briefly, the virus may become harder to treat. Contact your doctor or pharmacist when your supply is running low so you do not run out.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Oral liquid: Store in the refrigerator or at room temperature. Do not freeze.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Oral liquid: Children should take the oral liquid with food. Adults should take it without food. Retake if you vomit within 30 minutes of taking the medicine. Shake the oral liquid well just before each use. Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Oral liquid: Store in the refrigerator or at room temperature. Do not freeze.

  • Fosamprenavir is used together with other medicines to treat HIV infection. Take all of the medicines your doctor has prescribed at the right time of day and in the correct order. Do not stop using your medicine unless your doctor tells you to.

What to do if you miss a dose of Lexiva

Lexiva contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to fosamprenavir or amprenavir.

Lexiva warnings

  • Tell your doctor if you are pregnant, or if you have kidney disease, liver disease (including hepatitis B or C), anemia, diabetes, high cholesterol, or hemophilia. Tell your doctor if you are allergic to sulfa drugs.

  • Do not breastfeed. You can spread HIV or AIDS to your baby through your breast milk.

  • This medicine may cause the following problems:Serious skin reactionsLiver problemsHigh blood sugar levels, which could become permanentHemolytic anemia (blood disorder)Bleeding problemsKidney stones

  • Your immune system may get stronger when you start taking an HIV medicine. Infections that were hidden in your body, such as pneumonia or tuberculosis, might start to have symptoms. Tell your doctor right away if you notice any changes in your health.

  • This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Lexiva interactions

  • Do not use this medicine if you are also using alfuzosin, cisapride, delavirdine, dihydroergotamine, ergonovine, ergotamine, lomitapide, lovastatin, methylergonovine, oral midazolam, pimozide, rifampin, sildenafil, simvastatin, St John's wort, or triazolam. Do not use flecainide, lurasidone, or propafenone if you are also using ritonavir together with this medicine.

  • Many other drugs can interact with fosamprenavir. Make sure your doctor knows about all other medicines and supplements you are using.

  • This medicine may cause the following problems:Serious skin reactionsHigh blood sugar levels, a problem that could become permanentKidney stones

  • Your immune system may get stronger when you start taking an HIV medicine. Infections that were hidden in your body, such as pneumonia or tuberculosis, might start to have symptoms. Tell your doctor right away if you notice any changes in your health.

  • This medicine will not keep you from giving HIV to others. Always practice safe sex, even if your partner also has HIV. Do not share needles or other items that may have blood or body fluids on them.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Lexiva side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Trouble breathing, uneven heartbeat

  • Blood in the urine, pain in your side, painful or difficult urination

  • Increased hunger, thirst, or urination, unexplained weight loss

  • Unusual bleeding, bruising, or weakness

Less Serious Side Effects

  • Weight gain around your neck, upper back, breast, face, or waist

  • Diarrhea

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