What is Maprotiline Hcl: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Maprotiline Hcl overview

BRAND NAMES:

Generic Names:

  • Maprotiline Hcl

Uses:

  • Treats depression and anxiety. This medicine is a tetracyclic antidepressant.

Therapeutic Classes:

  • Antidepressant

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Maprotiline Hcl used for?

What form(s) does Maprotiline Hcl come in

  • Tablet

What are common Maprotiline Hcl doses?

  • Tablet 25MG

  • Tablet 50MG

  • Tablet 75MG

Common Maprotiline Hcl prescriptions

  • Maprotiline HCl
    25mg tablet

  • Maprotiline HCl
    50mg tablet

  • Maprotiline HCl
    75mg tablet

How to take Maprotiline Hcl

  • Your doctor will tell you how much to take and how often. Take this medicine exactly as ordered by your doctor.

  • Do not stop taking maprotiline suddenly without first asking your doctor.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Your doctor will tell you how much to take and how often. Take this medicine exactly as ordered by your doctor.

  • Do not stop taking maprotiline suddenly without first asking your doctor.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

What to do if you miss a dose of Maprotiline Hcl

  • Take the missed dose as soon as possible.

  • If it is almost time for your next regular dose, wait until then to take the medicine and skip the missed dose.

  • You should not use two doses at the same time.

Maprotiline Hcl contraindications

  • You should not use this medicine if you have ever had an allergic reaction to maprotiline. Check with your doctor before taking this medicine if you have seizures (epilepsy), if you have recently had a heart attack, or if you are taking monoamine oxidase (MAO) inhibitors such as Marplan®, Parnate, Nardil®.

Maprotiline Hcl warnings

  • If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.

  • Make sure your doctor knows if you have had heart problems, overactive thyroid, glaucoma, or if you have trouble urinating.

  • For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.

  • Maprotiline may make you drowsy or dizzy. Be careful driving a car or operating machinery.

Maprotiline Hcl interactions

  • Do not drink alcohol while taking this medicine.

  • Make sure your doctor knows if you are taking other medicines that could make you drowsy, such as sleeping pills, tranquilizers, cold and allergy medicines, and pain killers.

  • For some children, teenagers, and young adults, this medicine may increase mental or emotional problems. This may lead to thoughts of suicide and violence. Talk with your doctor right away if you have any thoughts or behavior changes that concern you. Tell your doctor if you or anyone in your family has a history of bipolar disorder or suicide attempts.

  • Maprotiline may make you drowsy or dizzy. Be careful driving a car or operating machinery.

Maprotiline Hcl side effects

Serious Side Effects

  • Skin rash, hives, or itching

  • Seizures

  • Irregular or rapid heartbeat

  • Psychosis (delusions, paranoia)

  • Changes in vision such as trouble focusing

  • Weight gain

Less Serious Side Effects

  • Trouble urinating

  • Drowsiness, dizziness, or tiredness

  • Changes in vision such as trouble focusing

  • Nausea, upset stomach, dry mouth

  • Weight gain

  • Constipation

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