What is Methylene Blue: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Methylene Blue overview

BRAND NAMES:

  • Provayblue

Generic Names:

  • Methylene Blue

Uses:

  • Treats methemoglobinemia.

Therapeutic Classes:

  • Antidote, Diagnostic Agent, Diagnostic Agent, Kidney Function

Forms:

  • Injectable

How it’s taken:

  • Into a vein

What is Methylene Blue used for?

Methylene Blue is a prescription only medication that is used to manage the amount of methemoglobin in the body. Methylene Blue controls the production of methemoglobin within the body. This medication is available as a injectable solution.

What form(s) does Methylene Blue come in

  • Injectable

What are common Methylene Blue doses?

  • Vial 1ML of 1%

  • Vial 10ML of 1%

Common Methylene Blue prescriptions

  • Methylene Blue
    2ml of 20mg/2ml syringe

  • Methylene Blue
    10ml of 50mg/10ml vial

How to take Methylene Blue

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

What to do if you miss a dose of Methylene Blue

Methylene Blue contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to methylene blue or any thiazine dye, or if you are pregnant.

Methylene Blue warnings

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

  • This medicine may cause dizziness, confusion, or vision problems. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

  • Tell your doctor if you have kidney disease, liver disease, or a glucose-6-phosphate dehydrogenase (G6PD) deficiency.

  • Do not breastfeed during treatment and for up to 8 days afterward.

  • This medicine may cause the following problems: Serious drug reaction called serotonin syndrome (usually when taken with medicine to treat depression)Hemolytic anemia

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

Methylene Blue interactions

  • Some medicines can affect how methylene blue works. Tell your doctor if you are using any of the following:Alfentanil, cyclosporine, digoxin, dihydroergotamine, ergotamine, fentanyl, linezolid, phenytoin, pimozide, quinidine, sirolimus, tacrolimus, or warfarinMAO inhibitorsMedicine to treat depression (including SSRIs, bupropion, buspirone, clomipramine, mirtazapine, venlafaxine)Medicine to treat migraine headaches

  • Tell your doctor if you have kidney disease, liver disease, or a glucose-6-phosphate dehydrogenase (G6PD) deficiency.

  • Do not breastfeed during treatment and for up to 8 days afterward.

  • This medicine may cause dizziness, confusion, or vision problems. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • This medicine may cause the following problems: Serious drug reaction called serotonin syndrome (usually when taken with medicine to treat depression)Hemolytic anemia

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Methylene Blue side effects

Serious Side Effects

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there

  • Trouble breathing, tiredness, uneven heartbeat, yellow skin or eyes

  • Unusual bleeding or bruising

Less Serious Side Effects

  • Headache, dizziness, vision changes

  • Blue discoloration of the skin

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed

  • Change in sense of taste

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