What is Mimvey: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Mimvey overview

BRAND NAMES:

  • Mimvey Lo, Lopreeza, Amabelz, Activella, Mimvey

Generic Names:

  • Estradiol-Norethindrone Acet

Uses:

  • Treats hot flashes, night sweats, and vaginal dryness due to menopause, and helps prevent osteoporosis after menopause.

Therapeutic Classes:

  • Estrogen/Progestin Combination

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Mimvey used for?

Lopreeza is used to help reduce symptoms of menopause including hot flashes and vaginal dryness. It contains two female hormones; an estrogen and a progestin and is only prescribed for women who still have their uterus.

What form(s) does Mimvey come in

  • Tablet

What are common Mimvey doses?

  • Disp Pack 28 Tablets

Common Mimvey prescriptions

  • Mimvey
    1 package (28 tablets), 1-0.5mg disp pack

How to take Mimvey

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • This medicine comes in a dispenser pack with a calendar reminder dial.To use this dispenser, first turn the inner disc so the current day of the week is lined up with the plastic tab. Pull the plastic tab up and break if off. Remove the first tablet.To get the next tablet out (on the next day), turn the dial one space clockwise as shown by the arrow.The dial can be turned only after the tablet in the opening has been removed. This will help you remember to take 1 tablet every day.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • This medicine comes in a dispenser pack with a calendar reminder dial.To use this dispenser, first turn the inner disc so the current day of the week is lined up with the plastic tab. Pull the plastic tab up and break if off. Remove the first tablet.To get the next tablet out (on the next day), turn the dial one space clockwise as shown by the arrow.The dial can be turned only after the tablet in the opening has been removed. This will help you remember to take 1 tablet every day.

What to do if you miss a dose of Mimvey

Mimvey contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to estradiol or norethindrone, you are pregnant, or you have liver disease. Do not use it if you have had breast cancer, uterine cancer, unusual vaginal bleeding, or problems with blood clots (such as deep vein thrombosis or stroke).

Mimvey warnings

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Vision changes, vision loss, double vision, migraine headache

  • You may need to stop using this medicine for a few weeks before and after surgery, or if you need to stay in bed for a long time. This is because of the risk of blood clots.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. You should have regular pelvic exams, breast exams, and mammograms as directed by your doctor.

  • This medicine may cause the following problems:Higher risk of heart attack, stroke, or blood clotsHigher risk of endometrial cancer, breast cancer, or uterine cancerHigher risk of dementiaGallbladder diseaseHigh calcium levels

  • Tell your doctor if you have kidney disease, heart disease, asthma, diabetes, endometriosis, epilepsy, migraine headaches, porphyria, lupus, an underactive thyroid, high blood pressure, or high cholesterol. Tell your doctor if you have ever had liver problems caused by pregnancy or estrogen, if you smoke, or if you had a hysterectomy.

  • Tell your doctor if you have had a heart attack, bleeding problems, or any kind of cancer.

  • Pregnancy after menopause is not likely, but if you think you could be pregnant, tell your doctor. This medicine could harm an unborn baby.

Mimvey interactions

  • Tell your doctor if you have kidney disease, heart disease, asthma, diabetes, endometriosis, epilepsy, migraine headaches, porphyria, lupus, an underactive thyroid, high blood pressure, or high cholesterol. Tell your doctor if you have ever had liver problems caused by pregnancy or estrogen, if you smoke, or if you had a hysterectomy.

  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

  • Some medicines can affect how estradiol/norethindrone works. Tell your doctor if you are using St John's wort, carbamazepine, clarithromycin, erythromycin, itraconazole, ketoconazole, phenobarbital, rifampin, or ritonavir.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments. You should have regular pelvic exams, breast exams, and mammograms as directed by your doctor.

  • You may need to stop using this medicine for a few weeks before and after surgery, or if you need to stay in bed for a long time. This is because of the risk of blood clots.

  • This medicine may cause the following problems:Higher risk of heart attack, stroke, or blood clotsHigher risk of endometrial cancer, breast cancer, or uterine cancerHigher risk of dementiaGallbladder diseaseHigh calcium levels

Mimvey side effects

Serious Side Effects

  • Unusual or unexpected vaginal bleeding or heavy bleeding

  • Vision changes, vision loss, double vision, migraine headache

  • Sudden or severe stomach pain, nausea, or vomiting

  • Numbness or weakness on one side of your body

  • Sudden or severe headache, problems with vision, speech, or walking

  • Chest pain that may spread, trouble breathing, coughing up blood, unusual sweating, fainting

  • Breast lumps

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Back pain

  • Nausea, stomach pain, or upset stomach

  • Swelling in your hands, ankles, or feet

  • Light, irregular vaginal bleeding or spotting

  • Swollen or tender breasts

  • Mild headache or trouble sleeping

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