What is mitoXANTRONE HCl: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Apr 11, 2021

mitoXANTRONE HCl overview

BRAND NAMES:

Generic Names:

  • Mitoxantrone Hcl

Uses:

  • Treats the symptoms of multiple sclerosis (MS). Also treats prostate cancer and certain types of leukemia (such as acute nonlymphocytic leukemia or ANLL).

Therapeutic Classes:

  • Antineoplastic Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is mitoXANTRONE HCl used for?

What form(s) does mitoXANTRONE HCl come in

  • Injectable

What are common mitoXANTRONE HCl doses?

  • Vial 10ML of 20MG/10ML

Common mitoXANTRONE HCl prescriptions

  • mitoXANTRONE HCl
    10ml of 20mg/10ml vial

  • mitoXANTRONE HCl
    12.5ml of 25mg/12.5ml vial

How to take mitoXANTRONE HCl

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • If this medicine gets on your skin, rinse the area well with warm water and tell your doctor. If the medicine gets in your eyes, rinse your eyes with large amounts of water, and tell your doctor.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

What to do if you miss a dose of mitoXANTRONE HCl

  • Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

mitoXANTRONE HCl contraindications

  • You should not receive this medicine if you have had an allergic reaction to mitoxantrone, or if you are pregnant or breastfeeding.

mitoXANTRONE HCl warnings

  • Injection routeIt is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Your doctor may require you to have a pregnancy test before you receive each dose of this medicine, to make sure you are not pregnant.

  • Make sure your doctor knows if you have liver disease, anemia, blood clotting problems, bone marrow problems, low white blood cell counts, bleeding problems, or any kind of infection. Also, tell your doctor if you have had cancer treatment or radiation in the past.

  • Make sure your doctor knows if you have heart or blood vessel disease, congestive heart failure, or any type of swelling (such as in your ankles, feet, or hands). Your doctor may need to check your heart function before you start using this medicine.

  • If you have pain, burning, redness, or swelling of your skin area where the IV needle is placed, tell your doctor right away.

  • This medicine may change the color of your urine to bluish-green. The whites of your eyes may also appear slightly bluish-green. This is normal, especially within the first 24 hours after you receive the medicine.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Your doctor may also want to check your heart while you are using this medicine.

  • Injection routeCancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.

  • Swelling in your hands, ankles, or feet.

  • Uncontrollable nausea, vomiting, or diarrhea.

  • Uneven heartbeats.

  • Unusual bleeding or bruising.

  • Unusual tiredness or weakness.

  • Yellowing of your skin or the whites of your eyes.

mitoXANTRONE HCl interactions

  • Tell your doctor about all other medicines you are using, radiation treatment, and all other cancer medicines you have received in the past.

  • This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

  • Make sure your doctor knows if you have heart or blood vessel disease, congestive heart failure, or any type of swelling (such as in your ankles, feet, or hands). Your doctor may need to check your heart function before you start using this medicine.

  • If you have pain, burning, redness, or swelling of your skin area where the IV needle is placed, tell your doctor right away.

  • This medicine may change the color of your urine to bluish-green. The whites of your eyes may also appear slightly bluish-green. This is normal, especially within the first 24 hours after you receive the medicine.

  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Your doctor may also want to check your heart while you are using this medicine.

  • Injection routeCancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.

mitoXANTRONE HCl side effects

Serious Side Effects

  • Swelling in your hands, ankles, or feet.

  • Unusual bleeding or bruising.

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Burning, pain, swelling, or bruising of your skin where the needle is placed.

  • Fever, chills, cough, runny or stuffy nose, sore throat, and body aches.

  • Nausea, vomiting, loss of appetite, or pain in your upper stomach.

  • Pain or burning when you urinate, change in how much or how often you urinate.

  • Pain or redness at the place of injection.

  • Rapid weight gain.

  • Shortness of breath, cold sweat, and bluish-colored skin.

  • Uneven heartbeats.

  • Yellowing of your skin or the whites of your eyes.

  • Unusual tiredness or weakness.

  • Uncontrollable nausea, vomiting, or diarrhea.

Less Serious Side Effects

  • Mild nausea, constipation, diarrhea, heartburn, vomiting, or stomach pain or upset.

  • Changes in your menstrual periods.

  • Headache.

  • Back pain, bone pain.

  • Depressed mood.

  • Sores or white patches on your lips, mouth, or throat.

  • Hair loss.

  • Blue skin at the place of injection.

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