What is Natpara? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Natpara overview

BRAND NAMES:

  • Natpara

Generic Names:

  • Natpara

Uses:

  • Helps control low blood calcium levels in patients who have hypoparathyroidism.

Therapeutic Classes:

  • Endocrine-Metabolic Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Natpara used for?

Natpara is used together with calcium and vitamin D to treat low levels of calcium in the blood in people who also have low levels of parathyroid hormone. Parathyroid hormone helps to regulate and maintain the balance of calcium and phosphorus in your body.

What form(s) does Natpara come in?

  • Injectable

What are common Natpara dosages?

  • Cartridge 1 Cartridge

Natpara images - What does Natpara look like?

  • Natpara
    1 cartridge cartridge

How to take Natpara

  • Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

  • Injection routeUse a new needle and syringe each time you inject your medicine.

  • Follow your doctor's instructions about how to take vitamin D and calcium supplements while you are using this medicine.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. Ask your doctor if you need to take extra calcium supplements if you miss a dose.

  • After you mix Natpara®, store the medication cartridge in the Q-Cliq pen in the refrigerator for up to 14 days. Store away from heat and light. Do not freeze or shake. Throw away the leftover medicine and cartridge 14 days after mixing.

  • Injection routeUse a new needle and syringe each time you inject your medicine.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose. Ask your doctor if you need to take extra calcium supplements if you miss a dose.

  • Injection routeYou may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Follow your doctor's instructions about how to take vitamin D and calcium supplements while you are using this medicine.

  • Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.

  • After you mix Natpara®, store the medication cartridge in the Q-Cliq pen in the refrigerator for up to 14 days. Store away from heat and light. Do not freeze or shake. Throw away the leftover medicine and cartridge 14 days after mixing.

What to do if you miss a dose of Natpara

Natpara contraindications - Who shouldn't take Natpara?

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to parathyroid hormone.

Natpara warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, bone disease (such as Paget disease of the bone), or a history of radiation treatment.

  • This medicine may cause the following problems:Higher risk of bone tumorsHigh or low blood calcium levels

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Injection routeThrow away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Natpara interactions & what to avoid when taking Natpara

  • Some foods and medicines can affect how this medicine works. Tell your doctor if you are also using digoxin or alendronate.

  • This medicine may cause the following problems:Higher risk of bone tumorsHigh or low blood calcium levels

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Injection routeThrow away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Natpara side effects - How does Natpara make you feel?

Serious Side Effects

  • Confusion, dry mouth, muscle weakness, stomach pain, weight loss

  • Painful or tender lump under the skin

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Bone pain that does not go away

  • Muscle twitching, numbness or tingling in your fingers, toes, or around your mouth

Less Serious Side Effects

  • Diarrhea, vomiting

  • Mild burning or tingling in the hands or toes

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