What is Nesacaine MPF: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Apr 11, 2021

Nesacaine MPF overview

BRAND NAMES:

  • Nesacaine, Nesacaine-MPF

Generic Names:

  • Chloroprocaine Hcl (Pf)

Uses:

  • Numbs your skin or some parts of your body before surgery or other medical procedures. This medicine is a local anesthetic.

Therapeutic Classes:

  • Anesthetic, Local

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Nesacaine MPF used for?

What form(s) does Nesacaine MPF come in

  • Injectable

What are common Nesacaine MPF doses?

  • Vial 20ML of 2%

How to take Nesacaine MPF

  • A nurse or other trained health professional will give you this medicine in a medical facility. You may receive the injection into your rib cage, chest, or other body areas. Only Nesacaine®-MPF is given through a catheter placed into your lower back for an epidural or a spinal block.

  • Injection routeA nurse or other health provider will give you this medicine.

What to do if you miss a dose of Nesacaine MPF

Nesacaine MPF contraindications

  • This medicine is not right for everyone. Do not receive it if you had an allergic reaction to chloroprocaine or similar medicines, or to any of the drugs in the PABA ester group.

Nesacaine MPF warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, kidney disease, heart disease, heart rhythm problems, high or low blood pressure, lung or breathing problems, a blood disorder, G6PD, or nerve disease.

  • This medicine may cause methemoglobinemia (blood disorder).

  • You may experience temporary loss of sensation and movement, usually in the lower half of your body, if you receive this medicine into your lower back (epidural). It may be easier to hurt yourself without knowing it while your treated body area is still numb. Be careful to avoid injury until the feeling is back in the area and you are no longer numb.

  • If you are receiving Nesacaine®-MPF as an epidural to ease labor pains, it may take longer than normal for you to push your baby out. It is also possible that the baby may have unwanted effects after birth (including sleepiness, slow responses).

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Fever or increased sweating

  • Loss of movement of any part of your body

  • Tremors or seizures

Nesacaine MPF interactions

  • Some medicines can affect how chloroprocaine works. Tell your doctor if you are taking any of the following: Acetaminophen, chloroquine, metoclopramide, primaquine, quinine, sulfasalazineBlood pressure medicineCancer medicine (including cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase)Ergot medicineMedicine to treat an infection (including dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamide)Medicine to treat depressionMedicine to treat seizures (including phenobarbital, phenytoin, sodium valproate)Nitrate or nitrite medicine (including nitric oxide, nitroglycerin, nitroprusside, nitrous oxide)Phenothiazine medicine (including chlorpromazine, promethazine)

  • This medicine will temporarily numb your skin or a part of your body. Be careful not to injure the treated area. You may also have trouble walking.

  • If you receive this medicine during childbirth, your baby may be sleepy or have muscle weakness for the first day or two after birth.

Nesacaine MPF side effects

Serious Side Effects

  • Fever or increased sweating

  • Pale, gray, or blue lips, nails, or skin, dark urine, headache, unusual tiredness or weakness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Fainting or lightheadedness

  • Change in how much or how often you urinate

  • Fast, slow, or uneven heartbeat

  • Anxiety, dizziness, ringing in your ears, depression, or drowsiness

  • Tremors or seizures

Less Serious Side Effects

  • Pain, itching, burning, swelling, or a lump under your skin where the needle is placed