What is Nitromist: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Nitromist overview

BRAND NAMES:

  • Nitrolingual, NitroMist, Nitrostat, Nitrostat, Nitrostat

Generic Names:

  • Nitromist

Uses:

  • Treats or prevents angina (chest pain). This medicine is a nitrate.

Therapeutic Classes:

  • Antianginal, Coronary Vasodilator

Forms:

  • Powder, Spray, Tablet

How it’s taken:

  • By mouth

What is Nitromist used for?

Nitroglycerin is a prescription-only nitrate that is taken to treat or prevent the symptoms associated with angina including tightness, pain and pressure in the chest. Nitroglycerin works by widening the blood vessels to make blood flow easily.

What form(s) does Nitromist come in

  • Powder

  • Spray

  • Tablet

What are common Nitromist doses?

  • Bottle 4.0999999046325684GM of 400MCG/SPRAY

  • Bottle 8.5GM of 400MCG/SPRAY

Common Nitromist prescriptions

  • NitroMist
    4.1gm of 400mcg/spray bottle

  • NitroMist
    8.5gm of 400mcg/spray bottle

How to take Nitromist

  • Your doctor will tell you how much medicine to use. Do not use more than directed. Sit down before you take this medicine, because it could make you lightheaded.

  • You may use this medicine 5 to 10 minutes before an activity that can cause angina. This may help prevent the attack.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Powder: Empty the contents of a packet under your tongue. Close your mouth and breathe normally. Allow powder to dissolve without swallowing. Do not rinse or spit for 5 minutes after taking this medicine. Do not take more than 3 packets in 15 minutes. If you still have pain after you take a total of 3 packets, this is an emergency. Call 911. Do not drive yourself to the hospital.Store the powder at room temperature, away from heat, moisture, and direct light.

  • Tablets: Wet the tablet with saliva and place it under your tongue or inside your cheek. Let the tablet dissolve. Do not chew, crush, or swallow the tablet. Wait 5 minutes. If you still have pain, take a second tablet. Do not take more than 3 tablets in 15 minutes. If you still have pain after you take a total of 3 tablets, this is an emergency. Call 911. Do not drive yourself to the hospital.Store the tablets at room temperature in the original container, away from heat, moisture, and direct light.

  • Spray: To prime the spray before you use it for the first time: Point the Nitrolingual® Pumpspray bottle away from your face. Pump the spray 5 times. The medicine is now ready to use.If you do not use the medicine for 6 weeks, pump the spray 1 time to re-prime the bottle.If you do not use the medicine for 3 months, pump the spray 5 times to re-prime the bottle.Point the NitroMist® bottle away from your face. Pump the spray 10 times. The medicine is now ready to use.If you do not use the medicine for 6 weeks, pump the spray 2 times to re-prime the bottle.To use the spray: Hold the bottle upright and close to your mouth. Open your mouth and spray the medicine onto or under your tongue. Close your mouth right away. Do not inhale the spray or get it in your eyes. Do not rinse your mouth for at least 5 to 10 minutes.Wait 5 minutes. If you still have pain, use another spray. Do not use more than 3 sprays within 15 minutes.If you still have pain after you use a total of 3 sprays, this is an emergency. Call 911. Do not drive yourself to the hospital.Do not shake the bottle. Do not use the spray near heat, open flame, or while smoking.Check the fluid level regularly according to the medicine directions. Refill your prescription before the level falls too low.Store the spray in an upright position at room temperature, away from heat. Do not open or burn the spray container.

  • Tablets: Wet the tablet with saliva and place it under your tongue or inside your cheek. Let the tablet dissolve. Do not chew, crush, or swallow the tablet. Wait 5 minutes. If you still have pain, take a second tablet. Do not take more than 3 tablets in 15 minutes. If you still have pain after you take a total of 3 tablets, this is an emergency. Call 911. Do not drive yourself to the hospital.Store the tablets at room temperature in the original container, away from heat, moisture, and direct light.

  • You may use this medicine 5 to 10 minutes before an activity that can cause angina. This may help prevent the attack.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Spray: To prime the spray before you use it for the first time: Point the Nitrolingual® Pumpspray bottle away from your face. Pump the spray 5 times. The medicine is now ready to use.If you do not use the medicine for 6 weeks, pump the spray 1 time to re-prime the bottle.If you do not use the medicine for 3 months, pump the spray 5 times to re-prime the bottle.Point the NitroMist® bottle away from your face. Pump the spray 10 times. The medicine is now ready to use.If you do not use the medicine for 6 weeks, pump the spray 2 times to re-prime the bottle.To use the spray: Hold the bottle upright and close to your mouth. Open your mouth and spray the medicine onto or under your tongue. Close your mouth right away. Do not inhale the spray or get it in your eyes. Do not rinse your mouth for at least 5 to 10 minutes.Wait 5 minutes. If you still have pain, use another spray. Do not use more than 3 sprays within 15 minutes.If you still have pain after you use a total of 3 sprays, this is an emergency. Call 911. Do not drive yourself to the hospital.Do not shake the bottle. Do not use the spray near heat, open flame, or while smoking.Check the fluid level regularly according to the medicine directions. Refill your prescription before the level falls too low.Store the spray in an upright position at room temperature, away from heat. Do not open or burn the spray container.

  • Powder: Empty the contents of a packet under your tongue. Close your mouth and breathe normally. Allow powder to dissolve without swallowing. Do not rinse or spit for 5 minutes after taking this medicine. Do not take more than 3 packets in 15 minutes. If you still have pain after you take a total of 3 packets, this is an emergency. Call 911. Do not drive yourself to the hospital.Store the powder at room temperature, away from heat, moisture, and direct light.

  • Your doctor will tell you how much medicine to use. Do not use more than directed. Sit down before you take this medicine, because it could make you lightheaded.

What to do if you miss a dose of Nitromist

Nitromist contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to nitroglycerin or similar medicines.

Nitromist warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, anemia, low blood pressure, heart failure, heart disease, an enlarged heart, or a recent heart attack or stroke. Tell your doctor if you have a history of a head injury.

  • This medicine may cause severe low blood pressure. This can make you dizzy or lightheaded. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. These symptoms may be worse if you drink alcohol.

  • Medicine that treats chest pain sometimes causes headaches when you first start using it. This is normal. Do not stop using the medicine to avoid headaches. Ask your doctor if you can take aspirin or acetaminophen to treat the headache.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Throbbing, severe, or ongoing headache, confusion, low fever, vision problems

  • Trouble breathing, cold sweat, blue skin, lips, or nails

  • Warmth or redness in your face, neck, arms, or upper chest

Nitromist interactions

  • Do not use this medicine if you are also using avanafil, riociguat, sildenafil, tadalafil, or vardenafil.

  • Some foods and medicines can affect how nitroglycerin works. Tell your doctor if you are using any of the following:Alteplase, aspirin, heparinBlood pressure medicinesDiuretic (water pill)Ergot medicines

  • Tell your doctor if you are using any medicine that makes your mouth dry, such as medicines that treat depression.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Nitromist side effects

Serious Side Effects

  • Throbbing, severe, or ongoing headache, confusion, low fever, vision problems

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blurred vision

  • Increased chest pain, fast or slow heartbeat

  • Trouble breathing, cold sweat, blue skin, lips, or nails

  • Severe or ongoing dizziness, lightheadedness, or fainting

  • Warmth or redness in your face, neck, arms, or upper chest

Less Serious Side Effects

  • Numbness or tingling in your hands, ankles, or feet

  • Dry mouth

  • Nausea or vomiting

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