What is Nocdurna: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Nocdurna overview

BRAND NAMES:

  • Nocdurna

Generic Names:

  • Nocdurna

Uses:

  • Treats nocturnal polyuria (frequent urination and increased volume of urine at night).

Therapeutic Classes:

  • Endocrine-Metabolic Agent

Forms:

  • Tablet

How it’s taken:

  • Under the tongue

What is Nocdurna used for?

What form(s) does Nocdurna come in

  • Tablet

What are common Nocdurna doses?

  • Box 30 Tablets Sublingual

Common Nocdurna prescriptions

  • Nocdurna
    30 tablets sublingual box

How to take Nocdurna

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Your doctor may instruct you to empty your bladder before bedtime.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Keep the tablet under your tongue until it has fully dissolved. Do not use this medicine with water.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Keep the tablet under your tongue until it has fully dissolved. Do not use this medicine with water.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Your doctor may instruct you to empty your bladder before bedtime.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

What to do if you miss a dose of Nocdurna

Nocdurna contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to desmopressin, or if you are thirsty most of the time and drink large amounts of fluids, have a condition called syndrome of inappropriate antidiuretic hormone, inflammation of the stomach or bowels, moderate to severe kidney disease, any type of infection, heart failure, or uncontrolled high blood pressure.

Nocdurna warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, increased pressure in the head, or a history of trouble passing urine.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. You may need to collect and measure your urine and the times that you urinate for 24 hours.

  • This medicine may cause low levels of sodium in your blood and body swelling. Carefully follow your doctor's instructions about how much liquid to drink each day.

Nocdurna interactions

  • Some medicines can affect how desmopressin works. Tell your doctor if you are using any of the following:Medicine to treat depression (including SSRIs, TCAs)Medicine to treat diabetes (including chlorpropamide)Medicine to treat mental illness (including chlorpromazine)Medicine to treat seizures (including carbamazepine, lamotrigine)Narcotic pain relieverNSAID pain or arthritis medicine (including aspirin, diclofenac, ibuprofen, naproxen)Thiazide diuretic (water pill, including hydrochlorothiazide)

  • Limit the amount of fluids you drink from 1 hour before using this medicine and until 8 hours after. Also avoid drinks containing caffeine or alcohol before bedtime.

  • Do not use this medicine together with certain diuretics (water pill, including furosemide, torsemide) or systemic or inhaled glucocorticoids (including dexamethasone, fluticasone, methylprednisolone, prednisolone, prednisone).

Nocdurna side effects

Serious Side Effects

  • Confusion, weakness, muscle twitching

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Rapid weight gain, swelling of your feet, legs, or ankles

Less Serious Side Effects

  • Dry mouth