What is Pentazocine-Naloxone Hcl? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Pentazocine-Naloxone Hcl overview

BRAND NAMES:

  • Talwin NX

Generic Names:

  • Pentazocine-Naloxone Hcl

Uses:

  • Relieves moderate to severe pain. This medicine is a narcotic pain reliever.

Therapeutic Classes:

  • Analgesic

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Pentazocine-Naloxone Hcl used for?

What form(s) does Pentazocine-Naloxone Hcl come in?

  • Tablet

What are common Pentazocine-Naloxone Hcl dosages?

  • Tablet 50-0.5MG

Pentazocine-Naloxone Hcl images - What does Pentazocine-Naloxone Hcl look like?

  • Pentazocine-Naloxone HCl
    50-0.5mg tablet

How to take Pentazocine-Naloxone Hcl

  • Your doctor will tell you how much medicine to use. Do not use more than directed. An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.

  • You may take Talwin® with food or milk to avoid stomach upset.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Mixed unused tablets with used coffee grounds or kitty litter, then place it in a sealable bag, empty can, or other container before throwing into the trash. Ask your pharmacist about the best way to dispose of medicine you do not use.

  • You may take Talwin® with food or milk to avoid stomach upset.

  • Your doctor will tell you how much medicine to use. Do not use more than directed. An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Mixed unused tablets with used coffee grounds or kitty litter, then place it in a sealable bag, empty can, or other container before throwing into the trash. Ask your pharmacist about the best way to dispose of medicine you do not use.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

What to do if you miss a dose of Pentazocine-Naloxone Hcl

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Oral routeAsk your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Pentazocine-Naloxone Hcl contraindications - Who shouldn't take Pentazocine-Naloxone Hcl?

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to pentazocine or naloxone, or if you have severe lung or breathing problems (including severe asthma) or stomach or bowel blockage (including paralytic ileus).

Pentazocine-Naloxone Hcl warnings

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • Sleepiness or unusual drowsiness.

  • Severe stomach pain.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel disease, low blood pressure, a recent heart attack, adrenal problems, lung or breathing problems (including COPD, apnea), gallbladder problems, spine problems, mental illness, pancreas problems, porphyria, thyroid problems, prostate problems, trouble urinating, or a history of head injury, seizures, or alcohol or drug abuse. Tell your doctor if you have had any type of surgery.

  • This medicine may cause the following problems:Increased risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Increased risk of seizuresSerotonin syndrome, when used with certain medicines

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

Pentazocine-Naloxone Hcl interactions & what to avoid when taking Pentazocine-Naloxone Hcl

  • Do not use this medicine if you are using or have used an MAO inhibitor (including isocarboxazid, linezolid, phenelzine, selegiline, tranylcypromine) within the past 14 days.

  • Some medicines can affect how pentazocine/naloxone works. Tell your doctor if you are using any of the following:Glycopyrrolate, ipratropiumDiuretic (water pill)Medicine to treat anxiety, depression, or other mental health problems (including benzodiazepine medicine, MAO inhibitor, phenothiazine medicine, SNRIs, SSRIs, TCAs)

  • Avoid tobacco smoking while you are using this medicine.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are also using buprenorphine, nalbuphine, or a muscle relaxer.

  • Do not drink alcohol while you are using this medicine.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

Pentazocine-Naloxone Hcl side effects - How does Pentazocine-Naloxone Hcl make you feel?

Serious Side Effects

  • Extreme dizziness or weakness, shallow breathing, slow or uneven heartbeat, sweating, cold or clammy skin, seizures or tremors

  • Severe confusion, lightheadedness, dizziness, or fainting

  • Blue lips, fingernails, or skin, fast, slow, or uneven heartbeat

  • Numbness, tingling, or burning pain in your hands, arms, legs, or feet.

  • Severe constipation, stomach pain

  • Anxiety, restlessness, fast heartbeat, fever, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, or red skin rash

  • Seizures or tremors.

  • Sleepiness or unusual drowsiness.

  • Severe confusion or hallucinations (seeing things that are not there).

  • Severe stomach pain.

Less Serious Side Effects

  • Trouble sleeping.

  • Dry mouth.

  • Warmth or redness in your face, neck, arms, or upper chest.

  • Headache.

  • Weakness.

  • Blurred vision.

  • Mild rash or itching skin.

  • Constipation, diarrhea, nausea, vomiting, loss of appetite, stomach pain, or upset stomach.

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