What is Phenytoin Sodium: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Phenytoin Sodium overview

BRAND NAMES:

  • Phenytoin Sodium Novaplus

Generic Names:

  • Phenytoin Sodium

Uses:

  • Treats and prevents seizures.

Therapeutic Classes:

  • Anticonvulsant

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Phenytoin Sodium used for?

What form(s) does Phenytoin Sodium come in

  • Injectable

What are common Phenytoin Sodium doses?

  • Vial 2ML of 50MG/ML

  • Bottle 100GM of

Common Phenytoin Sodium prescriptions

  • Phenytoin Sodium
    2ml of 50mg/ml vial

  • Phenytoin Sodium
    5ml of 50mg/ml vial

How to take Phenytoin Sodium

  • This medicine is usually given only for a short time when you cannot take oral medicine, such as when you are in the hospital or when you have surgery.

  • A nurse or other health professional will give you this medicine. This medicine is given as a shot into a muscle or into a vein.

  • After your condition improves, your doctor might switch you to an oral medicine that works the same way. Talk to your doctor if you have any concerns about this.

  • This medicine is usually given only for a short time when you cannot take oral medicine, such as when you are in the hospital or when you have surgery.

  • A nurse or other health professional will give you this medicine. This medicine is given as a shot into a muscle or into a vein.

  • After your condition improves, your doctor might switch you to an oral medicine that works the same way. Talk to your doctor if you have any concerns about this.

What to do if you miss a dose of Phenytoin Sodium

Phenytoin Sodium contraindications

  • This medicine is not right for everyone. You should not receive this medicine if you had an allergic reaction to phenytoin or similar medicines, or if you are pregnant or have certain heart rhythm problems.

Phenytoin Sodium warnings

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

  • Tell your doctor if you are breastfeeding, or if you have kidney disease, liver disease, diabetes, heart disease, low blood pressure, or porphyria.

  • This medicine may cause the following problems:Serious skin reactions (may happen after treatment has stopped)Drug reaction with eosinophilia and systemic symptoms (DRESS), which may damage organs such as the liver, kidney, or heartLiver damageDecreased levels of blood cells, which may cause bleeding or increase your risk for infectionPurple glove syndrome, which may damage skin and tissues near the injection siteHigher blood sugar levels

  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Fever, skin rash, or swollen glands in your armpits, neck, or groin

  • Pain, changes in skin color, sores, peeling, or swelling at or near the injection site

  • Severe confusion, problems with balance or walking, slurred speech, tremors

  • Unusual bleeding, bruising, or weakness

Phenytoin Sodium interactions

  • Do not use this medicine together with delavirdine.

  • The list below includes some of the medicines that can interact with phenytoin. There are many other drugs not listed. Make sure your doctor knows the names of all the medicines you use.

  • Tell your doctor if you are using cancer medicine, birth control pills, medicine to treat an infection (including a sulfa drug, medicine to treat HIV/AIDS, or medicine for a fungus infection), a steroid medicine, medicine to lower cholesterol, medicine to treat depression, a phenothiazine medicine, a blood thinner (such as ticlopidine, warfarin), or stomach medicine.

  • Do not drink alcohol while you are using this medicine.

  • Tell your doctor if you are using St John's wort, albendazole, amiodarone, aspirin, chlordiazepoxide, cyclosporine, diazepam, diazoxide, digoxin, disulfiram, folic acid, furosemide, isoniazid, methylphenidate, nisoldipine, praziquantel, quinidine, reserpine, rifampin, theophylline, tolbutamide, or vitamin D.

Phenytoin Sodium side effects

Serious Side Effects

  • Pain, changes in skin color, sores, peeling, or swelling at or near the injection site

  • Fast, slow, or pounding heartbeat, lightheadedness or fainting

  • Fever, chills, cough, sore throat, and body aches

  • Severe confusion, problems with balance or walking, slurred speech, tremors

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Fever, skin rash, or swollen glands in your armpits, neck, or groin

  • Unusual bleeding, bruising, or weakness

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, or red skin rash

Less Serious Side Effects

  • Mild nausea or vomiting

  • Dizziness, feeling of constant movement of self or surroundings

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