What is Posaconazole: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Posaconazole overview

BRAND NAMES:

  • Noxafil

Generic Names:

  • Posaconazole

Uses:

  • Treats or prevents fungus infections, especially in people who have a weak immune system.

Therapeutic Classes:

  • Antifungal

Forms:

  • Liquid, Delayed Release Tablet

How it’s taken:

  • By mouth

What is Posaconazole used for?

What form(s) does Posaconazole come in

  • Liquid

  • Delayed Release Tablet

What are common Posaconazole doses?

  • Tablet 100mg

Common Posaconazole prescriptions

  • Posaconazole
    105ml of 40mg/ml bottle

  • Posaconazole
    100mg tablet

  • Posaconazole
    100mg tablet delayed release

How to take Posaconazole

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Delayed-release tablet: Swallow the tablet whole. Do not crush, break, or chew it. Take this medicine with food.

  • Oral liquid:Shake the oral liquid well before using. Use the dosing spoon in the package to measure the dose. Rinse the measuring spoon with water after use and before storage.Take this medicine with a full meal or within 20 minutes after a meal. If you cannot eat a full meal, take it with a liquid nutritional supplement or an acidic drink, such as ginger ale.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: Take your dose of medicine as soon as you remember. If it is less than 12 hours until your next dose, just skip the missed dose and go back to your regular schedule. Do not take extra medicine to make up for the missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not freeze the oral liquid.

  • Delayed-release tablet: Swallow the tablet whole. Do not crush, break, or chew it. Take this medicine with food.

  • Missed dose: Take your dose of medicine as soon as you remember. If it is less than 12 hours until your next dose, just skip the missed dose and go back to your regular schedule. Do not take extra medicine to make up for the missed dose.

  • Oral liquid:Shake the oral liquid well before using. Use the dosing spoon in the package to measure the dose. Rinse the measuring spoon with water after use and before storage.Take this medicine with a full meal or within 20 minutes after a meal. If you cannot eat a full meal, take it with a liquid nutritional supplement or an acidic drink, such as ginger ale.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Take all of the medicine in your prescription to clear up your infection, even if you feel better after the first few doses.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not freeze the oral liquid.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

What to do if you miss a dose of Posaconazole

Posaconazole contraindications

  • This medicine is not right for everyone. Do not use if you had an allergic reaction to posaconazole or similar medicines.

Posaconazole warnings

  • Unusual bleeding, bruising, or weakness

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • This medicine can cause the following problems:Heart rhythm problemsLiver problems

  • Tell your doctor if you are pregnant or breastfeeding, or if you have a history of heart disease, kidney disease, liver disease, or heart rhythm problems (such as QT prolongation).

Posaconazole interactions

  • Do not use this medicine together with atorvastatin, lovastatin, pimozide, quinidine, simvastatin, sirolimus, or an ergot medicine.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Some foods and medicines can affect how posaconazole works. Tell your doctor if you are using cimetidine, cyclosporine, digoxin, esomeprazole, glipizide, metoclopramide, phenytoin, rifabutin, tacrolimus, vinblastine, vincristine, medicine for HIV/AIDS (such as atazanavir, efavirenz, fosamprenavir, ritonavir), a sedative medicine (such as alprazolam, midazolam, triazolam), or blood pressure medicine (such as diltiazem, felodipine, nicardipine, nifedipine, verapamil).

Posaconazole side effects

Serious Side Effects

  • Unusual bleeding, bruising, or weakness

  • Severe diarrhea or vomiting

  • Fast, slow, pounding, or uneven heartbeat

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Mild diarrhea, nausea, constipation

  • Fever

  • Headache

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