Learn more about prelief
Prelief (calcium glycerophosphate) is a brand-name, over-the-counter drug that relieves heartburn and indigestion triggered by acidic foods. It works by neutralizing the acid in acidic foods such as coffee, wine, and juices. Prelief costs $16.31 and is available at most major retailers and online stores. If a healthcare provider prescribes Prelief, a SingleCare Prelief coupon slashes the price down to $8.57 for a fill of 120, 340 (65-50)mg (ca-p) tablets. You can save up to 80% with your SingleCare discount card.
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About SingleCare Pricing
SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
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About Prelief
Prelief (calcium glycerophosphate) is a brand-name, over-the-counter drug that relieves heartburn and indigestion triggered by acidic foods. It works by neutralizing the acid in acidic foods such as coffee, wine, and juices. Prelief costs $16.31 and is available at most major retailers and online stores. If a healthcare provider prescribes Prelief, a SingleCare Prelief coupon slashes the price down to $8.57 for a fill of 120, 340 (65-50)mg (ca-p) tablets. You can save up to 80% with your SingleCare discount card.
Learn more about prelief
About Prelief
Prelief (calcium glycerophosphate) is a brand-name, over-the-counter drug that relieves heartburn and indigestion triggered by acidic foods. It works by neutralizing the acid in acidic foods such as coffee, wine, and juices. Prelief costs $16.31 and is available at most major retailers and online stores. If a healthcare provider prescribes Prelief, a SingleCare Prelief coupon slashes the price down to $8.57 for a fill of 120, 340 (65-50)mg (ca-p) tablets. You can save up to 80% with your SingleCare discount card.
Prelief FAQs
How much does Prelief cost without insurance?
On average, The Prelief price is $16.31. With a SingleCare coupon for Prelief, it costs only $8.57.
How much does Prelief cost with insurance?
Prelief is not covered by insurance plans as a prescription drug with a copay. However, with SingleCare, Prelief costs $8.57. SingleCare discounts are available for over-the-counter (OTC) products, like Prelief, when prescribed by a physician.
Does Medicare cover Prelief and how much does it cost?
Because Prelief is an inexpensive over-the-counter drug, no Medicare prescription drug plan covers purchases of Prelief.
For Medicare patients who have been prescribed Prelief by their doctor, significant savings are available with a SingleCare Prelief coupon. Your Prelief price with a SingleCare discount card is only $8.57.
Is there a generic of Prelief?
Prelief is a brand-name over-the-counter drug. The generic version is calcium glycerophosphate, and it usually comes as a powder or tablet.
What is Prelief?
Prelief is a brand-name, over-the-counter drug for people who suffer irritation when they eat or drink acidic foods, such as coffee, wine, tomato sauce, citrus juices, and other foods. The active ingredient is calcium glycerophosphate, which, according to the manufacturer, “removes” 95% of acid from acidic foods. Calcium glycerophosphate is technically an “antacid,” that is, it buffers and neutralizes acid solutions in the foods you eat.
Prelief is a prophylactic (preventative) that comes in tablet and powder form; the powder is meant to be stirred into the food before eating (coffee, wine, juice, tomato sauce, etc.). Two tablets are taken immediately before mealtime.
Prelief and its active ingredient have been shown to help relieve symptoms and discomfort arising from interstitial cystitis (a condition in which the patient feels continual pressure in the bladder) and overactive bladder. Many patients use Prelief solely for their bladder problems rather than for heartburn.
What are the side effects of Prelief?
The most common side effect of Prelief is taste impairment (foods don't taste right). Less common side effects include, but are not limited to, constipation and swelling of the ankles or feet. Taken in excess, Prelief can contribute to kidney stones. Allergic reactions and mood changes are very rare.
Where are Prelief coupons from SingleCare accepted?
SingleCare is accepted at most national pharmacies and grocers, including the following:
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