Provayblue Coupons & Prices

Methylene Blue

Provayblue (methylene blue) is a brand-name prescription injection used to restore normal hemoglobin in patients with methemoglobinemia, a condition in which the iron in the red blood cells becomes oxidized and cannot efficiently transport oxygen to the cells. Provayblue is administered by a healthcare professional as an intravenous infusion. Provayblue's cost is normally $225.02 at full price. A SingleCare Provayblue coupon reduces that price to $92.35. Ask the clinic or hospital where you receive your Provayblue infusion if they will accept a SingleCare Provayblue coupon; you could pay only $92.35.

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Provayblue coupon at Walgreens Pharmacy
$95.35
$ 92.35
$3 off with signupwith signup

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Provayblue coupon at CVS Pharmacy
$95.38
$ 92.38
$3 off with signupwith signup

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Provayblue coupon at Publix Pharmacy
$152.32
$ 149.32
$3 off with signupwith signup
Provayblue coupon at Kroger Pharmacy
$214.25
$ 211.25
$3 off with signupwith signup
Provayblue coupon at Harris Teeter Pharmacy
$214.25
$ 211.25
$3 off with signupwith signup
Provayblue coupon at Walmart Neighborhood Market Pharmacy
$232.01
$ 229.01
$3 off with signupwith signup
$232.01
$ 229.01
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

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About Provayblue

Provayblue (methylene blue) is a brand-name prescription injection used to restore normal hemoglobin in patients with methemoglobinemia, a condition in which the iron in the red blood cells becomes oxidized and cannot efficiently transport oxygen to the cells. Provayblue is administered by a healthcare professional as an intravenous infusion. Provayblue's cost is normally $225.02 at full price. A SingleCare Provayblue coupon reduces that price to $92.35. Ask the clinic or hospital where you receive your Provayblue infusion if they will accept a SingleCare Provayblue coupon; you could pay only $92.35.

About Provayblue

Provayblue (methylene blue) is a brand-name prescription injection used to restore normal hemoglobin in patients with methemoglobinemia, a condition in which the iron in the red blood cells becomes oxidized and cannot efficiently transport oxygen to the cells. Provayblue is administered by a healthcare professional as an intravenous infusion. Provayblue's cost is normally $225.02 at full price. A SingleCare Provayblue coupon reduces that price to $92.35. Ask the clinic or hospital where you receive your Provayblue infusion if they will accept a SingleCare Provayblue coupon; you could pay only $92.35.

Provayblue FAQs

How much does Provayblue cost without insurance?

Provayblue costs around $225.02 for uninsured customers. With a SingleCare Provayblue coupon, you will pay only $92.35 for the same infusion if the hospital or clinic where you receive it accepts SingleCare.

How much does Provayblue cost with insurance?

Your copay for Provayblue with insurance will vary depending on your plan and the price charged for Provayblue by the hospital or clinic for the infusion. However, Provayblue may be covered by your health insurance as a medical benefit rather than a prescription drug benefit. Ask the clinic or hospital where you receive your Provayblue infusion if they will accept a SingleCare Provayblue coupon; you could pay only $92.35.

Does Medicare cover Provayblue and how much does it cost?

Provayblue is not covered by Medicare Part D and Medicare Advantage prescription drug plans, but instead is covered for all Medicare patients under Medicare Part B. For patients without Medicare, ask the clinic or hospital where you receive your Provayblue infusion if they will accept a SingleCare Provayblue coupon; you could pay only $92.35.

Is there a generic of Provayblue?

Provayblue is a brand-name prescription drug with the active ingredient methylene blue. Generic methylene blue is manufactured by Akorn and American Regent, the manufacturer of Provayblue, and sells for the same price as Provayblue. However, Provayblue is purchased by hospitals and clinics only, so they will decide which product to purchase.

What is Provayblue?

Provayblue is a brand-name prescription injection administered to patients with acquired methemoglobinemia, an anemia in which the red blood cells have too much methemoglobin rather than hemoglobin. Methemoglobin does not carry oxygen like hemoglobin. It is formed when the iron in hemoglobin (ferrous iron) is oxidized (into ferric iron). The oxidized iron is unable to carry oxygen. Too much methemoglobin in the bloodstream will result in not enough oxygen getting to the body's tissues. Symptoms are gray-blue skin, weakness, and tiredness.

People can be born with methemoglobinemia or acquire it from chemical agents such as prescription drugs or nitrites.

The active ingredient in Provayblue, methylene blue, reduces the oxidized iron (ferric iron) in methemoglobin back to its oxygen-carrying form (ferrous iron).

Provayblue is administered by a healthcare professional as an infusion that will last from 5-30 minutes. The patient will be monitored throughout the infusion, including vital signs, an electrocardiogram, and methemoglobin levels. The effects of Provayblue on methemoglobin will be immediate. If methemoglobin levels are still high after the first infusion, a second will be administered an hour later.

What are the side effects of Provayblue?

Patients will be closely monitored during and after their injection. The most common side effects of Provayblue are temporary site reactions to the infusion. These include pain, irritation, redness, and soreness. Other common side effects of Provayblue include but are not limited to pain in the extremities, changes in taste, nausea, sweating, dizziness, feeling hot, headache, and skin discoloration.

The most severe side effects can include anaphylaxis, a dangerous drop in blood pressure, and hemolytic anemia, a condition in which blood cells die off.

Provayblue allergies are very rare. Consult a physician immediately if you show any signs of a Provayblue allergic reaction, such as itching, rash, facial swelling, dizziness, or trouble breathing.

This is not a complete list of side effects that may occur. Ask your doctor or pharmacist about possible side effects before taking this medicine.

Where are Provayblue coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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