What is Pyrazinamide: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Pyrazinamide overview

BRAND NAMES:

Generic Names:

  • Pyrazinamide

Uses:

  • Treats tuberculosis (TB), usually in combination with other TB drugs.

Therapeutic Classes:

  • Antitubercular

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Pyrazinamide used for?

Pyrazinamide is a miscellaneous antituberculosis agent used to treat children and adults with tuberculosis. This medication must be combined with other TB medicines to be effective. If taken alone tuberculosis can become resistant to the treatment.

What form(s) does Pyrazinamide come in

  • Tablet

What are common Pyrazinamide doses?

  • Tablet 500MG

Common Pyrazinamide prescriptions

  • Pyrazinamide
    500mg tablet

How to take Pyrazinamide

  • May be taken with or without food or milk.

  • Your doctor will tell you how much to take and how often.

  • Take this medicine exactly as your doctor ordered. You must take this medicine for as long as your doctor ordered. Even if you feel better, do not stop taking this medicine.

  • Your doctor will tell you how much to take and how often.

  • Take this medicine exactly as your doctor ordered. You must take this medicine for as long as your doctor ordered. Even if you feel better, do not stop taking this medicine.

  • May be taken with or without food or milk.

What to do if you miss a dose of Pyrazinamide

  • You should not use two doses at the same time.

  • Take the missed dose as soon as you remember.

  • Skip the missed dose if it is almost time for your next regular dose.

Pyrazinamide contraindications

  • You should not use this medicine if you have had an allergic reaction to pyrazinamide, ethionamide, isoniazid (INH) or niacin (nicotinic acid, Nicobid®).

Pyrazinamide warnings

  • Check with your doctor before taking this medicine if you have diabetes, gout or liver disease.

  • Talk with your doctor before taking this medicine if you are pregnant or breastfeeding.

  • Yellowing of the skin or eyes

  • Fever or chills

  • Dark urine

Pyrazinamide interactions

  • Check with your doctor before taking this medicine if you have diabetes, gout or liver disease.

  • Talk with your doctor before taking this medicine if you are pregnant or breastfeeding.

Pyrazinamide side effects

Serious Side Effects

  • Fever or chills

  • Dark urine

  • Yellowing of the skin or eyes

  • Skin rash, severe itching or hives

  • Pain or swelling in the joints

Less Serious Side Effects

  • Unusual tiredness or loss of appetite

  • Nausea or vomiting

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