What is Regranex? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Regranex overview

BRAND NAMES:

  • Regranex

Generic Names:

  • Regranex

Uses:

  • Treats diabetic skin ulcers (sores).

Therapeutic Classes:

  • Wound Care Agent

Forms:

  • Gel/Jelly

How it’s taken:

  • On the skin

What is Regranex used for?

What form(s) does Regranex come in?

  • Gel/Jelly

What are common Regranex dosages?

  • Tube 15GM of 0.01%

Regranex images - What does Regranex look like?

  • Regranex
    15gm of 0.01% tube

How to take Regranex

  • Use this medicine only on your skin and only on the area prescribed by your doctor. Do not get it into your eyes, nose, mouth, or vagina. Do not apply this medicine on any other rashes, sores, or cuts. If it does get on these areas, rinse it off right away.

  • Your doctor will tell you how much medicine to use. Depending on how quickly your skin ulcer heals, your doctor may change the dose of your medicine. Use of more medicine than your doctor prescribed will not help your skin ulcer heal more quickly.

  • Topical application routeWash your hands with soap and water before and after you use this medicine.

  • Squeeze the gel onto a clean surface that will not absorb the medicine, including a piece of wax paper. Do not apply the medicine directly from the tube onto the skin.

  • Use a cotton swab, tongue depressor, or other applicator aid to spread an thin, even layer of gel over the surface of the skin ulcer.

  • Cover the skin ulcer with a gauze dressing that has been moistened with saline solution. Leave the skin ulcer covered for 12 hours. After 12 hours, remove the gauze. Carefully rinse the skin ulcer with saline or water to remove any medicine that remains. Do not apply more medicine. Put another saline-moistened gauze dressing on the area for the next 12 hours.

  • Do not let the tip of the tube touch the skin ulcer or any other object. Close the tube tightly after each use.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Topical application routeApply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

  • Store this medicine in the refrigerator. Do not freeze.

  • Your doctor will tell you how much medicine to use. Depending on how quickly your skin ulcer heals, your doctor may change the dose of your medicine. Use of more medicine than your doctor prescribed will not help your skin ulcer heal more quickly.

  • Use a cotton swab, tongue depressor, or other applicator aid to spread an thin, even layer of gel over the surface of the skin ulcer.

  • Topical application routeWash your hands with soap and water before and after you use this medicine.

  • Cover the skin ulcer with a gauze dressing that has been moistened with saline solution. Leave the skin ulcer covered for 12 hours. After 12 hours, remove the gauze. Carefully rinse the skin ulcer with saline or water to remove any medicine that remains. Do not apply more medicine. Put another saline-moistened gauze dressing on the area for the next 12 hours.

  • Missed dose: Topical application routeApply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.

  • Do not let the tip of the tube touch the skin ulcer or any other object. Close the tube tightly after each use.

  • Store this medicine in the refrigerator. Do not freeze.

  • Squeeze the gel onto a clean surface that will not absorb the medicine, including a piece of wax paper. Do not apply the medicine directly from the tube onto the skin.

  • Use this medicine only on your skin and only on the area prescribed by your doctor. Do not get it into your eyes, nose, mouth, or vagina. Do not apply this medicine on any other rashes, sores, or cuts. If it does get on these areas, rinse it off right away.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

What to do if you miss a dose of Regranex

Regranex contraindications - Who shouldn't take Regranex?

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to becaplermin, or if you have skin cancer or tumor at the application site.

Regranex warnings

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have poor blood flow to your lower legs and feet, or any type of cancer.

  • Only use the prescribed amount of medicine. Too much of this medicine may increase your risk for cancer away from the application site. Your doctor will decide if you should continue to use this medicine based on how well your skin ulcer heals.

  • Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.

Regranex interactions & what to avoid when taking Regranex

  • Do not use other medicines on your skin ulcer at the same time you are using becaplermin, unless instructed by your doctor.

  • Topical application routeDo not put cosmetics or skin care products on the treated skin.

  • Topical application routeDo not use this medicine to treat a skin problem your doctor has not examined.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Regranex side effects - How does Regranex make you feel?

Serious Side Effects

  • Pain, redness, warmth, burning, or swelling around the application site

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

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