Santyl is an FDA-approved medication that is used to remove dead skin tissues from severe burns or skin ulcers. Currently, there is no generic version of Santyl, which can be cheaper than their brand-name equivalent. However, you can consider using SingleCare's printable coupons to receive prescription drug discounts. Without applying a prescription savings offer, the cost of Santyl is about $441.85 for 1, 30gm of 250unit/gm tube of ointment. However, you can use your free Santyl coupon at a participating pharmacy and pay only $312.48 for your medication. Kroger, Walmart, and Walgreens are some of the participating pharmacies that accept SingleCare coupons. You can visit SingleCare's website to locate a nearby participating pharmacy.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/20/2025
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Santyl is an FDA-approved medication that is used to remove dead skin tissues from severe burns or skin ulcers. Currently, there is no generic version of Santyl, which can be cheaper than their brand-name equivalent. However, you can consider using SingleCare's printable coupons to receive prescription drug discounts. Without applying a prescription savings offer, the cost of Santyl is about $441.85 for 1, 30gm of 250unit/gm tube of ointment. However, you can use your free Santyl coupon at a participating pharmacy and pay only $312.48 for your medication. Kroger, Walmart, and Walgreens are some of the participating pharmacies that accept SingleCare coupons. You can visit SingleCare's website to locate a nearby participating pharmacy.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Santyl Retail Price | Santyl SingleCare Price |
|---|---|---|
| CVS Pharmacy | $366.60 | $331.50 |
| Walmart | $381.00 | $339.00 |
| Walgreens | $380.55 | $337.28 |
| Kroger Pharmacy | $381.00 | $315.60 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Santyl is an FDA-approved medication that is used to remove dead skin tissues from severe burns or skin ulcers. Currently, there is no generic version of Santyl, which can be cheaper than their brand-name equivalent. However, you can consider using SingleCare's printable coupons to receive prescription drug discounts. Without applying a prescription savings offer, the cost of Santyl is about $441.85 for 1, 30gm of 250unit/gm tube of ointment. However, you can use your free Santyl coupon at a participating pharmacy and pay only $312.48 for your medication. Kroger, Walmart, and Walgreens are some of the participating pharmacies that accept SingleCare coupons. You can visit SingleCare's website to locate a nearby participating pharmacy.
Without any insurance plan coverage, the average retail price of Santyl would be about $441.85 for 1, 30gm of 250unit/gm tube of ointment. You can save money on your prescriptions by carrying your discount card to a participating pharmacy. Your SingleCare discount card can lower your price to $312.48 on your prescription.
Ask your pharmacist about your copay with your current insurance coverage plan. SingleCare can be the most affordable option than using your own insurance plan. A savings card from SingleCare can lower your price to $312.48 for 1, 30gm of 250unit/gm tube of ointment. When you visit a participating pharmacy, ask the pharmacist to swipe your Santyl discount card to compare prescription prices.
Medicare typically covers Santyl and the copay can run between $25-$281. You can take your Santyl discount card to participating pharmacies like CVS Pharmacy or Target to receive a prescription discount. Visit SingleCare's website to locate a participating pharmacy within your area.
Santyl is a brand-name drug. Collagenase topical is the generic name of Santyl. Currently, there is not a generic equivalent to Santyl available in the U.S. market.
Santyl is a prescription drug that is used to remove dead tissue from wounds such as severe burns and ulcers. When a wound starts to heal, nonliving tissue can appear on the affected area. As a result, non-living tissue can cause bacteria to grow around the area which can cause the wound to be contaminated.
Collagenase is the active ingredient found in Santyl that aids in the process of breaking down peptide bonds found in collagen. Collagen is a protein that your body needs to maintain connective tissues. When you receive a second or third-degree burn, you may need to increase the amount of collagen in your body to help your wound heal properly.
Santyl is available as a topical ointment. Before using Santyl, you should talk to your healthcare provider to see if Santyl is right for you. If you are pregnant or breastfeeding, you should inform your healthcare professional. You should ask your healthcare provider for medical advice if Santyl does not help with your recovery process.
Some, but not all, side effects of using Santyl include feeling a painful or burning sensation around the affected area, temporary redness, and irritation. A serious side effect of removing dead skin tissue is a condition called sepsis. Sepsis is an infection that has spread to your blood and can cause you to experience fever or chills, hyperventilation, and weakness.
If you experience any of these side effects along with other abnormal bodily changes, you should contact your healthcare provider. You can also file a report of your side effects to the FDA by calling 1-800-FDA-1088.
Kristi C. Torres, Pharm.D., is a 2005 graduate of The University of Texas at Austin. Her professional background includes academic teaching roles, district-level management for a nationwide pharmacy chain, and clinic-based pharmacy management. Dr. Torres has a wide range of experience in pharmacy operations and has traveled to many states to open and convert clinic-based pharmacies for one of the largest healthcare systems in the nation.
Currently, she works for Tarrytown Expocare Pharmacy in Austin, Texas, serving the intellectual and developmental disability community. There, she leads the order entry team, overseeing orders from across the country.
Dr. Torres began working in pharmacy at the age of 16 in a small East Texas town. She currently resides in Round Rock, Texas, with her daughter and a Shih-Tzu puppy.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved