Santyl Coupons & Prices

Santyl is an FDA-approved medication that is used to remove dead skin tissues from severe burns or skin ulcers. Currently, there is no generic version of Santyl, which can be cheaper than their brand-name equivalent. However, you can consider using SingleCare's printable coupons to receive prescription drug discounts. Without applying a prescription savings offer, the cost of Santyl is about $441.85 for 1, 30gm of 250unit/gm tube of ointment. However, you can use your free Santyl coupon at a participating pharmacy and pay only $312.48 for your medication. Kroger, Walmart, and Walgreens are some of the participating pharmacies that accept SingleCare coupons. You can visit SingleCare's website to locate a nearby participating pharmacy.

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Santyl coupon at Kroger Pharmacy
$315.48
$ 312.48
$3 off with signupwith signup

Show this free card to your pharmacist.

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Santyl coupon at Harris Teeter Pharmacy
$315.48
$ 312.48
$3 off with signupwith signup

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Santyl coupon at Food Lion Pharmacy
$ 331.82
Santyl coupon at Walmart Neighborhood Market Pharmacy
$338.85
$ 335.85
$3 off with signupwith signup
Santyl coupon at Walmart Pharmacy
$338.85
$ 335.85
$3 off with signupwith signup
Santyl coupon at Publix Pharmacy
$339.44
$ 336.44
$3 off with signupwith signup
$340.24
$ 337.24
$3 off with signupwith signup
$342.95
$ 339.95
$3 off with signupwith signup
$345.69
$ 342.69
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/20/2025

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About Santyl

Santyl is an FDA-approved medication that is used to remove dead skin tissues from severe burns or skin ulcers. Currently, there is no generic version of Santyl, which can be cheaper than their brand-name equivalent. However, you can consider using SingleCare's printable coupons to receive prescription drug discounts. Without applying a prescription savings offer, the cost of Santyl is about $441.85 for 1, 30gm of 250unit/gm tube of ointment. However, you can use your free Santyl coupon at a participating pharmacy and pay only $312.48 for your medication. Kroger, Walmart, and Walgreens are some of the participating pharmacies that accept SingleCare coupons. You can visit SingleCare's website to locate a nearby participating pharmacy.

Santyl Price History & Information

Price History for Santyl

1 count, tube of ointment, 30gm of 250unit/gm

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Santyl

1 count, tube of ointment, 30gm of 250unit/gm
PharmacySantyl Retail PriceSantyl SingleCare Price
CVS Pharmacy$366.60$331.50
Walmart$381.00$339.00
Walgreens$380.55$337.28
Kroger Pharmacy$381.00$315.60

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Santyl

Santyl is an FDA-approved medication that is used to remove dead skin tissues from severe burns or skin ulcers. Currently, there is no generic version of Santyl, which can be cheaper than their brand-name equivalent. However, you can consider using SingleCare's printable coupons to receive prescription drug discounts. Without applying a prescription savings offer, the cost of Santyl is about $441.85 for 1, 30gm of 250unit/gm tube of ointment. However, you can use your free Santyl coupon at a participating pharmacy and pay only $312.48 for your medication. Kroger, Walmart, and Walgreens are some of the participating pharmacies that accept SingleCare coupons. You can visit SingleCare's website to locate a nearby participating pharmacy.

Santyl FAQs

Medically reviewed by Kristi C. TorresPharm.D.
Licensed Pharmacist

How much does Santyl cost without insurance?

Without any insurance plan coverage, the average retail price of Santyl would be about $441.85 for 1, 30gm of 250unit/gm tube of ointment. You can save money on your prescriptions by carrying your discount card to a participating pharmacy. Your SingleCare discount card can lower your price to $312.48 on your prescription.

How much does Santyl cost with insurance?

Ask your pharmacist about your copay with your current insurance coverage plan. SingleCare can be the most affordable option than using your own insurance plan. A savings card from SingleCare can lower your price to $312.48 for 1, 30gm of 250unit/gm tube of ointment. When you visit a participating pharmacy, ask the pharmacist to swipe your Santyl discount card to compare prescription prices.

Does Medicare cover Santyl and how much does it cost?

Medicare typically covers Santyl and the copay can run between $25-$281. You can take your Santyl discount card to participating pharmacies like CVS Pharmacy or Target to receive a prescription discount. Visit SingleCare's website to locate a participating pharmacy within your area.

Is there a generic of Santyl?

Santyl is a brand-name drug. Collagenase topical is the generic name of Santyl. Currently, there is not a generic equivalent to Santyl available in the U.S. market.

What is Santyl?

Santyl is a prescription drug that is used to remove dead tissue from wounds such as severe burns and ulcers. When a wound starts to heal, nonliving tissue can appear on the affected area. As a result, non-living tissue can cause bacteria to grow around the area which can cause the wound to be contaminated.

Collagenase is the active ingredient found in Santyl that aids in the process of breaking down peptide bonds found in collagen. Collagen is a protein that your body needs to maintain connective tissues. When you receive a second or third-degree burn, you may need to increase the amount of collagen in your body to help your wound heal properly.

Santyl is available as a topical ointment. Before using Santyl, you should talk to your healthcare provider to see if Santyl is right for you. If you are pregnant or breastfeeding, you should inform your healthcare professional. You should ask your healthcare provider for medical advice if Santyl does not help with your recovery process.

What are the side effects of Santyl?

Some, but not all, side effects of using Santyl include feeling a painful or burning sensation around the affected area, temporary redness, and irritation. A serious side effect of removing dead skin tissue is a condition called sepsis. Sepsis is an infection that has spread to your blood and can cause you to experience fever or chills, hyperventilation, and weakness.

If you experience any of these side effects along with other abnormal bodily changes, you should contact your healthcare provider. You can also file a report of your side effects to the FDA by calling 1-800-FDA-1088.

Medically reviewed by Kristi C. TorresPharm.D.
Licensed Pharmacist

Kristi C. Torres, Pharm.D., is a 2005 graduate of The University of Texas at Austin. Her professional background includes academic teaching roles, district-level management for a nationwide pharmacy chain, and clinic-based pharmacy management. Dr. Torres has a wide range of experience in pharmacy operations and has traveled to many states to open and convert clinic-based pharmacies for one of the largest healthcare systems in the nation.

Currently, she works for Tarrytown Expocare Pharmacy in Austin, Texas, serving the intellectual and developmental disability community. There, she leads the order entry team, overseeing orders from across the country.

Dr. Torres began working in pharmacy at the age of 16 in a small East Texas town. She currently resides in Round Rock, Texas, with her daughter and a Shih-Tzu puppy.

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Where are Santyl coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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