What is Tolbutamide: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Tolbutamide overview

BRAND NAMES:

Generic Names:

  • Tolbutamide

Uses:

  • Treats diabetes mellitus. Belongs to a class of drugs called sulfonylureas.

Therapeutic Classes:

  • Hypoglycemic

Forms:

  • Tablet

How it’s taken:

  • By mouth

What is Tolbutamide used for?

Tolbutamide is combined with diet and exercise to treat patients with type 2 diabetes. Tolbutamide triggers the pancreas to produce insulin which helps the body to lower the blood sugar level.

What form(s) does Tolbutamide come in

  • Tablet

What are common Tolbutamide doses?

  • Tablet 500MG

Common Tolbutamide prescriptions

  • TOLBUTamide
    500mg tablet

How to take Tolbutamide

  • Your doctor will tell you how much to take and how often.

  • Your doctor will tell you how much to take and how often.

  • Skip the missed dose if it is almost time for your next regular dose.

  • You should not use two doses at the same time.

What to do if you miss a dose of Tolbutamide

  • Take the missed dose as soon as possible.

  • Skip the missed dose if it is almost time for your next regular dose.

  • You should not use two doses at the same time.

Tolbutamide contraindications

  • You should not use this medicine if you have ever had an allergic reaction to tolbutamide or other sulfonylurea drugs such as Tolinase®, chlorpropamide, or Glucotrol®. You should not use this medicine if you are pregnant.

Tolbutamide warnings

  • This medicine may make your skin sensitive to sunlight. Use a sunscreen when outdoors. Avoid sunlamps or tanning beds.

  • Talk with your doctor before taking this medicine if you are breastfeeding or if you have liver, kidney, or heart disease, G-6-PD deficiency, or a thyroid disorder.

  • To control your diabetes, follow the diet that your doctor orders and take this medicine on a regular schedule.

  • You may have low blood sugar while you are taking tolbutamide, especially if you miss a meal, exercise for a long time, or drink alcohol. Symptoms of low blood sugar include sweating, feeling very hungry, fast heartbeat, drowsiness, confusion, headache that won't go away, chills, or vomiting.

  • Ask your doctor what you should do in case you have low blood sugar. You will need to control it quickly.

  • Make sure your doctor knows you are taking this medicine before you have any kind of surgery.

Tolbutamide interactions

  • Avoid drinking alcohol while you are taking this medicine.

  • While using this medicine, avoid taking aspirin or cough and cold medicines.

  • Tolbutamide interacts with many medicines. Before you start taking tolbutamide, make sure your doctor knows of all other medicines you are taking.

  • Ask your doctor what you should do in case you have low blood sugar. You will need to control it quickly.

  • Make sure your doctor knows you are taking this medicine before you have any kind of surgery.

  • This medicine may make your skin sensitive to sunlight. Use a sunscreen when outdoors. Avoid sunlamps or tanning beds.

Tolbutamide side effects

Serious Side Effects

  • Dark colored urine or light colored stools

  • Unexplained fever, chills or sore throat

  • Unusual bleeding or bruising

  • Yellowing of skin or eyes

  • Severe skin rash or hives

Less Serious Side Effects

  • Sensitivity of skin to sunlight

  • Mild nausea or vomiting

  • Skin rash or itching

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